全文获取类型
收费全文 | 851篇 |
免费 | 41篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 52篇 |
妇产科学 | 17篇 |
基础医学 | 143篇 |
口腔科学 | 29篇 |
临床医学 | 101篇 |
内科学 | 117篇 |
皮肤病学 | 8篇 |
神经病学 | 60篇 |
特种医学 | 63篇 |
外科学 | 74篇 |
综合类 | 23篇 |
预防医学 | 68篇 |
眼科学 | 1篇 |
药学 | 42篇 |
中国医学 | 9篇 |
肿瘤学 | 68篇 |
出版年
2022年 | 8篇 |
2021年 | 16篇 |
2020年 | 10篇 |
2019年 | 16篇 |
2018年 | 10篇 |
2017年 | 15篇 |
2016年 | 16篇 |
2015年 | 25篇 |
2014年 | 49篇 |
2013年 | 49篇 |
2012年 | 49篇 |
2011年 | 42篇 |
2010年 | 42篇 |
2009年 | 29篇 |
2008年 | 32篇 |
2007年 | 35篇 |
2006年 | 28篇 |
2005年 | 23篇 |
2004年 | 17篇 |
2003年 | 25篇 |
2002年 | 17篇 |
2001年 | 18篇 |
2000年 | 24篇 |
1999年 | 22篇 |
1998年 | 20篇 |
1997年 | 22篇 |
1996年 | 13篇 |
1995年 | 14篇 |
1994年 | 11篇 |
1993年 | 17篇 |
1992年 | 14篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 13篇 |
1988年 | 10篇 |
1987年 | 8篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1957年 | 2篇 |
1956年 | 2篇 |
1954年 | 2篇 |
1952年 | 16篇 |
1951年 | 23篇 |
1950年 | 2篇 |
排序方式: 共有896条查询结果,搜索用时 15 毫秒
1.
G. Rosa G. Pinto P. Orsi R. A. de Blasi G. Conti R. Sanit I. La Rosa A. Gasparetto 《Acta anaesthesiologica Scandinavica》1995,39(1):90-95
Postoperative shivering may be prevented by maintaining normothermia intraoperatively or it may be treated using specific drugs. The aim of this study was to compare the efficacy of nefopam hydrochloride (nefopam) to that of clonidine and meperidine in patients undergoing elective neurosurgical procedures. Three groups of patients were included in the study. Patients in group A (60) received i.v., at random, 20 mg of nefopam, 50 mg of meperidine or 150 μg of clonidine in the immediate postoperative period. The incidence of shivering and the time at which shivering ceased were noted, along with central temperature and main haemodynamic changes. Group B (20) received i.v., at random, either 10 mg of nefopam or saline before awakening from anaesthesia. The effects of nefopam on central temperature, oxygen consumption (Vo2), carbon dioxide production (VcO2), basal metabolic rate (BMR) and energy expenditure (EE) were investigated. Group C (10) received i.v. 20 mg of nefopam during surgery: cerebrospinal fluid pressure (CSFP), cerebral perfusion pressure (CPP) and electroencephalogram (EEG) were monitored. In group A nefopam stopped shivering in 95% of patients when compared to meperidine and clonidine, which were effective in 32% and 40% of patients respectively. In group B, only 10% of patients receiving nefopam had postoperative shivering, Vo2, VcO2 and EE were significantly lower in patients treated with nefopam than those in the control group. No changes in CSFP, CPP or EEG were observed in group C. In conclusion, nefopam seems to be more effective than clonidine or meperidine in quickly suppressing shivering, without producing significant adverse reactions. 相似文献
2.
用体外培养的人的伪表皮作为模型,进行药物毒理学作用的研究,观察了二甲亚砜(DMSO)在不同浓度和不同接触时间条件下,对人的伪表皮细胞脱氧核糖核酸(DNA)、核糖核酸(RNA)和蛋白质合成的影响:随着接触时间的延长,DNA、RNA和蛋白质合成均受抑制。低浓度条件下(1%),DNA、RNA和蛋白质合成增加;在15~50%浓度下,DNA和蛋白质合成抑制,而RNA合成仍增加;在高浓度条件下(70%~100%),DNA、RNA和蛋白质合成均明显抑制。 相似文献
3.
G. Rosa G. Conti P. Orsi F. D'Alessandro I. La Rosa G. Di Giugno A. Gasparetto 《Acta anaesthesiologica Scandinavica》1992,36(2):128-131
The effects of sedative-hypnotic doses of propofol on respiratory drive and pattern have not yet been extensively described. Repeated small boluses of propofol (0.6-0.3 mg.kg-1) were administered to ten ASA I patients undergoing carpal tunnel release using regional anaesthesia. Airway pressure, capnography and pneumotachography were continuously recorded. With respect to basal values, no significant variations of respiratory rate, minute volume, tidal volume, inspiratory and expiratory time, total expiratory cycle, Ti/Ttot, TV/Ti, P0.1, EtCO2 and blood gas analysis were observed. Low doses of propofol, to maintain conscious sedation of light sleep, have not been shown to cause respiratory depression. 相似文献
4.
P Visca F Chiarini A Mansi C Vetriani L Serino N Orsi 《Epidemiology and infection》1992,108(2):323-336
A total of 121 uropathogenic Pseudomonas aeruginosa strains were examined for production of several virulence-related factors. These strains were distributed in five predominant O-serotypes, i.e. O 4, O 12, O 11, O 6 and O 5, which accounted respectively for 23.9, 23.1, 12.3, 8.2 and 5.7% of isolates. Pyochelin and pyoverdin siderophores were produced by most of the isolates, defective variants occurring at very low frequency (2.4% for pyochelin and 7.4% for pyoverdin). Adherence to uroepithelial cells and production of cytotoxins was demonstrated in 52.8 and 67.7% of the strains, respectively, with higher frequencies for epidemiologically related strains belonging to serotypes O 4 and O 12. Titration of total proteases, elastase and phospholipase C revealed a high degree of heterogeneity among isolates. However, examination of individual O-serotypes by exoenzyme production showed that elevated levels of total proteases and elastase were characteristics of serotypes of minor numerical importance, i.e. O 1, O 10, O 11 and O 17, whilst low levels of elastase were produced by strains belonging to the predominant serotypes, namely O 4 and O 12. Moreover, epidemiologically related strains belonging to serotypes O 4 and O 12 appeared more homogeneous than the whole serogroup, when compared with other groups on the basis of exoenzyme levels. 相似文献
5.
6.
7.
8.
Telfer JF; Thomson AJ; Cameron IT; Greer IA; Norman JE 《Human reproduction (Oxford, England)》1997,12(10):2306-2312
Superoxide, an agent which attenuates the half-life of nitric oxide, is
metabolized and synthesized by superoxide dismutase (SOD) and xanthine
oxidase, respectively. Over the last few years much work has focused on the
role of nitric oxide in human parturition. The aim of this study was to
determine whether the onset of human parturition is associated with a
change in the expression of copper/zinc superoxide dismutase (Cu/Zn SOD),
manganese superoxide dismutase (Mn SOD) or xanthine oxidase within the
uterus. Samples of myometrium, placenta, decidua and fetal membranes were
obtained from women before and after the onset of labour at term.
Immunocytochemistry was used to localize Cu/Zn SOD, Mn SOD and xanthine
oxidase and measure SOD enzyme activity. Cu/Zn and Mn SOD-like
immunoreactivity was detected in syncytiotrophoblast cells, villous stromal
cells and endothelial cells of blood vessels in the placenta. In the
myometrium Cu/Zn and Mn SOD were localized to myocytes and endothelial
cells and to some vascular smooth muscle cells. In the fetal membranes we
observed staining for Cu/Zn SOD and Mn SOD in the amnion, chorion,
extravillous trophoblast and decidua. There was no difference in SOD enzyme
activity or staining intensity for SOD between different cell types before
and during labour. Xanthine oxidase immunoreactivity was identified in each
of the tissues examined and again there was no difference in immunostaining
in tissues obtained from women delivered before or after the onset of
labour. These results show that the pregnant uterus is capable of both
synthesizing and degrading superoxide and suggest that superoxide dismutase
and xanthine oxidase may play a role in the maintenance of uterine
quiescence during pregnancy, but not in the initiation of parturition.
相似文献
9.
Pre-eclampsia, one of the most significant health problems inhuman pregnancy, complicates 6-7% of all gestations and is theleading cause of fetal growth retardation, infant morbidityand mortality, premature birth and maternal death. Recent researchimplicates free radicals in the pathophysiology of pre-eclampsia.This review covers the biochemistry of nitric oxide (NO) andpossible interactions with other free radicals. Studies in therat show that pregnancy is associated with enhanced productionand responsiveness to NO in both reproductive tissues and bloodvessels. Rats infused with NG-nitro-L-arginine methyl ester(L-NAME, a NO synthase inhibitor) have been used as an animalmodel of pre-eclampsia, and the effects of steroid hormoneson blood pressure in this model have been tested. Results suggestthat pre-eclampsia may be a state of NO deficiency. However,in humans there seem to be contradictions regarding the involvementof NO in maternal adaptation to pregnancy. It is suggested thatNO may be one of several systems that act in concert to maintaina symbiotic relationship between mother and fetus. However,the input of each system may be genetically determined. 相似文献
10.
L. Sinibaldi P. Goldoni V. Pietropaolo C. Longhi N. Orsi 《Archives of virology》1990,113(3-4):291-296
Summary BK virus infectivity was inhibited by gangliosides extracted from Vero cells and by standard preparations of different gangliosides. Gangliosides were also able to restore the susceptibility of glycosidase-treated Vero cells to BK virus infection. 相似文献