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Intestinal schistosomiasis japonica: CT-pathologic correlation 总被引:1,自引:0,他引:1
Lee RC; Chiang JH; Chou YH; Rubesin SE; Wu HP; Jeng WC; Hsu CC; Tiu CM; Chang T 《Radiology》1994,193(2):539
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C.K. Ogle O. Trocki H. Nagy J.D. Ogle G.D. Warden J.W. Alexander 《Clinical nutrition (Edinburgh, Scotland)》1988,7(4)
This study was undertaken to determine if dietary eicosapentaenoic acid (EPA) could affect the production of PGE (PGE2 and/or PGE3) by splenic macrophages and the mitogen-induced proliferation of splenic lymphocytes.Guinea pigs received a 30% total body surface area burn following installation of gastrostomy feeding tubes. All animals received identical diets except for the lipid component which equalled 10% of total energy. The control diet contained only linoleic acid (LA) as the lipid component. The experimental diets contained increasing amounts of EPA. Fourteen days postburn, the animals were sacrificed and splenic lymphocytes and macrophages were obtained and cultured for lymphocyte proliferation with and without mitogen stimulation and for PGE2 synthesis in response to bacterial lipopolysaccharide (LPS), respectively.Increasing amounts of EPA in the diets had no statistically significant effect on the total production of PGE (PGE2 and/or PGE3) by macrophages stimulated with LPS, however, when 100% EPA was used as the lipid component, the production of PGE2 was increased. Also, increasing amounts of EPA in the diet did not affect lymphocyte proliferation following stimulation of the cells with various mitogens, although at an EPA:LA ratio of 75:25%, a significant increase in proliferation of unstimulated but not stimulated lymphocytes was observed. However, at a 100:0 ratio of EPA:LA, lymphocyte proliferation was back down to the control level. This study shows that dietary EPA in high concentrations may have some complex interaction with the immune system at least in the animal under the stress of a burn. 相似文献
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Because organ transplantation is the preferred treatment for organ failure, the demand for human organs for transplantation is large and growing. From this demand, several fields based on new technologies for the replacement or repair of damaged tissues and organs have emerged. These fields include stem cell biology, cloning, tissue engineering and xenotransplantation. Here we evaluate the potential contribution of these to the devising of alternative approaches to organ replacement. We present our vision for the development of two structurally complex organs – the lung and the kidney – based on a 'fusion' of new and established technologies. 相似文献