全文获取类型
收费全文 | 6541篇 |
免费 | 391篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 76篇 |
儿科学 | 155篇 |
妇产科学 | 72篇 |
基础医学 | 918篇 |
口腔科学 | 116篇 |
临床医学 | 414篇 |
内科学 | 1739篇 |
皮肤病学 | 329篇 |
神经病学 | 405篇 |
特种医学 | 130篇 |
外科学 | 819篇 |
综合类 | 75篇 |
一般理论 | 1篇 |
预防医学 | 277篇 |
眼科学 | 161篇 |
药学 | 523篇 |
中国医学 | 19篇 |
肿瘤学 | 741篇 |
出版年
2023年 | 27篇 |
2022年 | 76篇 |
2021年 | 163篇 |
2020年 | 108篇 |
2019年 | 105篇 |
2018年 | 176篇 |
2017年 | 138篇 |
2016年 | 156篇 |
2015年 | 145篇 |
2014年 | 208篇 |
2013年 | 296篇 |
2012年 | 422篇 |
2011年 | 461篇 |
2010年 | 264篇 |
2009年 | 236篇 |
2008年 | 406篇 |
2007年 | 445篇 |
2006年 | 401篇 |
2005年 | 386篇 |
2004年 | 398篇 |
2003年 | 354篇 |
2002年 | 358篇 |
2001年 | 121篇 |
2000年 | 137篇 |
1999年 | 110篇 |
1998年 | 72篇 |
1997年 | 70篇 |
1996年 | 54篇 |
1995年 | 42篇 |
1994年 | 34篇 |
1993年 | 35篇 |
1992年 | 63篇 |
1991年 | 40篇 |
1990年 | 37篇 |
1989年 | 41篇 |
1988年 | 37篇 |
1987年 | 38篇 |
1986年 | 24篇 |
1985年 | 34篇 |
1984年 | 33篇 |
1983年 | 30篇 |
1982年 | 15篇 |
1981年 | 14篇 |
1979年 | 13篇 |
1975年 | 20篇 |
1973年 | 12篇 |
1972年 | 12篇 |
1970年 | 14篇 |
1969年 | 10篇 |
1967年 | 12篇 |
排序方式: 共有6970条查询结果,搜索用时 15 毫秒
1.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
2.
3.
4.
Masaru Sasaki Tsuyoshi Takahashi Soichiro Funaki Koji Tanaka Yasuhiro Miyazaki Naoko Ose Tomoki Makino Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Yasushi Shintani Masaki Mori Yuichiro Doki 《Asian journal of endoscopic surgery》2021,14(1):116-119
We report a case of a diaphragmatic hernia after a heart transplant operation. A 43-year-old woman, who underwent orthotropic heart transplantation for hypertrophic cadiomyopathy two year earlier, presented with vomiting and epigastric pain. A computed tomography scan showed that the stomach and transverse colon were dislocated in the left thoracic cavity. We diagnosed left diaphragmatic hernia incarceration and performed laparoscopic repair of the diaphragmatic hernia. A 12 × 8 cm diaphragmatic defect was found intraoperatively on the ventrolateral aspect of the left diaphragm, and the stomach with volvulus had herniated into the thorax through the defect. The hernia was considered to be iatrogenic. The diaphragmatic defect was large, and the diaphragm was thinning. We closed the defect by mesh repair. Laparoscopic mesh repair of the diaphragmatic hernia could be performed safely and with minimal invasiveness. 相似文献
5.
6.
Eiki Tayama Shingo Chihara Shuji Fukunaga Hidetoshi Akashi Shigeaki Aoyagi Kei-Ichiro Mizoguchi 《Annals of thoracic and cardiovascular surgery》2007,13(3):206-208
A left ventricular rupture due to embolic myocardial infarction is extremely rare. A 72-year-old woman developed an acute embolic myocardial infarction and mitral regurgitation due to infective endocarditis. Two days after the infarction, a left ventricular free wall rupture occurred after transesophageal echo examination. She received an epicardial patch and mitral valve replacement. Perioperatively, an intra-aortic balloon pump and long-term antibiotics were used. The postoperative course was uneventful, and she is doing well 10 months after surgery. 相似文献
7.
8.
9.
Tetsuo Nagatani Megumi Miyazawa Toshiko Matsuzaki Gaijiro Iemoto Shu-taku Kim Naoko Baba Kanata Miyakawa Hideaki Miyamoto Hiroshi Nakajima Yoshio Hirai 《The Journal of dermatology》1993,20(10):623-629
A 45-year-old man was referred to our department in March of 1989. Physical examination showed erythroderma, palmo-plantar hyperkeratosis, generalized lymphadenopathy, hepatosplenomegaly, and leukemic manifestation. The lymphocyte count in the peripheral blood before treatment was 1.7 × 104 cells/mm3. Atypical lymphocytes such as flower cells and lobulated cells were seen in the peripheral blood. A sample excised from a lymph node showed immunoblastic, pleomorphic T cells by a modified classification scheme of the Working Formulation. A high level of serum LDH was detected (2.1 times the upper normal limit). Anti HTLV-1 antibody was also detected in the serum. The atypical lymphocytes were positive for CD3, CD4, CD5, CD7 and HLA-DR, and negative for CD8. Thus, the clinical, pathologic and immunologic features were those of typical acute-type ATL. The patient was treated with VEPA-M for three months starting in March of 1989. Because of poor response, the patient was then treated with MACOP-B, M-FEPA, and VEPP-B for about one year from June of 1989 and has been free of disease up to the time of writing, March of 1993. 相似文献
10.
Naoko Masuzawa Mitsuo Kishimoto Yoshiki Takahashi 《International journal of gynecological pathology》2003,22(3):285-288
A 57-year-old female presented with an abnormal Pap smear. Colposcopic examination of the cervix revealed white mucosa with erosion and several areas of black pigmentation. After a colposcopically directed biopsy and loop conization, radical hysterectomy and bilateral salpingo-oophorectomy with pelvic and paraaortic lymphadenectomy were performed. Pathological examination disclosed an invasive squamous cell carcinoma admixed with many dendritic melanocytes. Melanin granules were present within the melanocytes and tumor cells. Although similar tumors have been reported in other sites, this is the first report to our knowledge of a pigmented squamous cell carcinoma of the uterine cervix. 相似文献