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1.
TSUTOMU NOMURA KAZUHIDE HIGUCHI HIDENORI YU SHIN-ICHI SASAKI SHUJI KIMURA HIROYUKI ITOH MICHIYO TANIGUCHI TETSUO ARAKAWA KOKI KAWAI 《Journal of gastroenterology and hepatology》2006,21(1):54-58
Background and Aim: Although pretreatment with a sedative drug is effective in relieving pain during esophagogastroduodenoscopy (EGD), such drugs can cause significant side‐effects. The aim of this study was to examine the effect of slow‐wave photic stimulation on discomfort and/or pain felt during EGD. Methods: Forty consecutive patients (25 men and 15 women) who underwent diagnostic EGD in our hospital were included in the study. Twenty patients received photic stimulation for 25 min, and underwent electroencephalographic recording, in addition to the usual premedications. Twenty control patients received the same treatment but without photic stimulation. All patients evaluated the discomfort/pain felt during endoscopy against a five‐grade scale in comparison with what they had experienced in their previous examination. Results: Patients with an improved discomfort/pain score were 18/20 and 3/20 in the treated and control groups, respectively. Overall comparison of pain scores between both groups was significant (P < 0.0001). The proportion of slow‐wave activity recorded in patients’ electroencephalograms significantly increased in the treated group compared to control values (36.6 ± 6.8% vs 29.1 ± 3.4%, P < 0.001). There was a close correlation between the degree of discomfort/pain felt during endoscopy and the proportion of slow‐wave activity (P < 0.001). Conclusion: Slow‐wave photic stimulation shows promise as a treatment for relieving the discomfort and/or pain felt by patients undergoing EGD. 相似文献
2.
ATSUKO BABA KUNIHISA TANIGUCHI WATARU MOTOKAWA KAZUNARI ISHIBASHI ATSUHITO OKINA KIMIO ABE 《The Journal of pharmacy and pharmacology》1995,47(6):518-523
Fluid and protein secretion by the submandibular glands of 25-day-old rats were examined and compared in response to three cholinergic and four peptidergic sialogogues at various doses. All cholinergic and peptidergic agonists used were potent sialogogues for the submandibular glands of the weanling rats over the wide range of doses used. The cholinergic agonists, bethanechol and methacholine and the peptidergic agonists, substance P, substance PTyr8 and eledoisin-related peptide used intravenously, acted similarly to each other on the submandibular glands of the rats, late in the natural weaning period, but carbachol and physalaemin had slightly different effects. Of the peptidergic agonists, physalaemin was the most potent sialogogue among four tachykinins tested at the low dose. The types of protein secreted by the submandibular glands of the weanling rats in response to all sialogogues used here were typical of the β-type. These results indicate that all agonists used could mainly stimulate the acinar cells of the submandibular glands of the weanling rats which have already fully developed functionally at this time. 相似文献
3.
TANIGUCHI CHISA; YAMAGUCHI KAZUNARI; YOSHIOKA RITSUKO; TAKIFUJI NOBUHIDE; MATSUI KAORU; NISHIMURA HIROMICHI; TOMINO SHINHACHIRO; TAKATSUKI KIYOSHI; TANAKA RYUJI 《Japanese journal of clinical oncology》1984,14(1):123-127
We report a case of chronic myelogenous leukemia (CML) associatedwith pronounced peripheral lymphadenopathy, with the cells havingthe Philadelphia (Phl) chromosome and T-cell features. A 23-year-oldman who was diagnosed as having CML and treated with busulfanwas admitted to our hospital because of increasing hepatosplenomegalyand pronounced lymphadenopathy. An axillary lymph node biopsydisclosed that the malignant cells formed rosettes with neuraminidase-treatedsheep red blood cells (En) (95.0%) and were positive for Leu1 (91.8%). Of the cytochemical reactions, peroxidase was negativeand periodic acid-Shiff, acid -naphthyl acetate esterase andß-glucuronidase were all positive. The karyotype ofthe bone marrow cells was 46 XY Phl positive (22q), andthat of the lymph node cells was 51 XY Phl positive +8, +9,+18, +19, +21, 22q. He was treated with various anti-leukemicagents and irradiation. Despite such treatments, he died ofpneumonia. This is a report of a CML patients with blast crisisand tumor formation characterized by T-cell features. 相似文献
4.
白花前胡化学成分研究 Ⅲ 总被引:1,自引:0,他引:1
目的:研究河南产白花前胡的化学成分.方法:采用色谱法分离化学成分,利用质谱、核磁共振等波谱技术鉴定结构.结果:分离鉴定了7个化合物,分别为α-D-ghcopyranose-1-hexadeeanoate(1),D-mannitol monohexadecanoate(2),腺苷(adenosine,3),丁酸(butyric acid,4),eleutheroside B_1(5),apiosylskimmin(6),甘露醇(mannitol,7).结论:化合物1~5为首次从该植物中分离得到,化合物1,2为首次从伞形科植物中分离得到. 相似文献
5.
ICHIRO OHNO KAZUKO SHINODA KEIKO TSUGAWA NOBORU TAKIZAWA NOBORU TANIGUCHI SEIJI KIMURA 《Pediatrics international》1995,37(4):507-509
A 13 month old boy was found to have severely reduced β-galactocerebrosidase activity suggesting infantile Krabbe disease. Clinically, the patient showed a progressive neurological deterioration with white-matter disease on radiological study. Axillary skin biopsy was performed to support the diagnosis. On electron microscopy, needle-like inclusions, which are the typical finding seen in the cytoplasm of astrocytes and Schwann cells in the classic infantile form, were present in eccrine sweat gland epithelial cells. This method is useful for diagnosis when nerve biopsy and biochemical analysis are not readily available. 相似文献
6.
目的 :为确认中药白芷的基原植物提供化学成分方面的资料。方法 :运用高效液相及与标准品对照的方法对 4类栽培白芷 (川、杭、祁、禹白芷 )和 3种近缘野生植物 (兴安白芷、台湾白芷、雾灵当归 ) ,以及另外 2种当归属野生植物 (黑水当归、芷叶白芷 )进行了香豆素类成分的比较分析。结果 :4类栽培白芷和 3种近缘野生植物的香豆素类成分无论在化合物种类还是在含量方面都相当近似 ,而与另外 2种当归属野生植物差别较大。结论 :从香豆素类成分特征来看 ,4类栽培白芷和 3种近缘野生植物可分为 3个类群 ,即 :①川、杭、祁、禹 4类白芷和台湾白芷。②兴安白芷。③雾灵当归。台湾白芷与中药白芷更为接近 相似文献
7.
中药白芷的基原植物研究Ⅳ.白芷的基原植物、栽培历史以及其近缘野生植物演化的讨论 总被引:4,自引:1,他引:4
目的 :确认中药白芷的基原植物 ,探讨其栽培历史变化以及有关近缘野生植物的演化。方法 :对已取得的各项研究结果作综合分析 ,并结合历史文献、分布现状等进行讨论。结果 :各项研究结果与历史文献、分布现状等均较为一致。结论 :①中药白芷的基原植物应是台湾白芷。②建议将雾灵当归处理为兴安白芷的变种 ,定名为A .dahuricavar.porphyrocaulis。③对川 (杭 )白芷和祁 (禹 )白芷不应作分类学上的区分。同时 ,还对中药白芷的使用栽培历史和白芷的野生近缘植物兴安白芷、台湾白芷和雾灵当归的演化关系作出了推断。 相似文献
8.
9.
YOSHIAKI KANEKO M.D. Ph .D. TADASHI NAKAJIMA M.D. Ph .D. AKIHIRO SAITO M.D. TADANOBU IRIE M.D. MASAKI OTA M.D. TOSHIMITSU KATO M.D. TAKAFUMI IIJIMA M.D. MAMORU MANITA M.D. Ph .D. TOSHIO ITO M.D. MASAHIRO AKIYAMA M.D. Ph .D. YASUHIRO TANIGUCHI M.D. MASAHIKO KURABAYASHI M.D. Ph .D. 《Pacing and clinical electrophysiology : PACE》2009,32(S1):S72-S75
Background: The purpose of this study was to identify the His-bundle (HB) versus right bundle branch (RBB) during electrophysiologic studies, using the V3 phenomenon, and to compare the timing of HB versus RBB potentials of sinus cycles (His-ventricular [H-V] interval).
Methods: The study enrolled 16 patients without structural heart disease, who underwent electrophysiologic studies during which the H-V interval was within normal limits and the V3 phenomenon was induced during recordings of the HB and the RBB potentials by a multi-electrode catheter. The recording site of the earliest HB potential just before the V3 phenomenon was defined as the branching portion of His bundle (HBBP), the site immediately proximal to the HBBP as the HB, and the site immediately distal to the HBBP as the RBB.
Results: The HBBP was identified in all patients. In all cases but one patient, the H-V interval measured at the HB adjacent to the HBBP was ≥35 ms. However, in 12 patients, the H-V interval measured at the RBB adjacent to the HBBP was also ≥35 ms.
Conclusions: The electrophysiologic identification of HB versus RBB by simultaneous recordings of HB and RBB potentials during induction of the V3 phenomenon was feasible. When the discrimination between HB and RBB was based on the measurement of the H-V interval, the proximal portion of the RBB was frequently misidentified as the HB. 相似文献
Methods: The study enrolled 16 patients without structural heart disease, who underwent electrophysiologic studies during which the H-V interval was within normal limits and the V3 phenomenon was induced during recordings of the HB and the RBB potentials by a multi-electrode catheter. The recording site of the earliest HB potential just before the V3 phenomenon was defined as the branching portion of His bundle (HBBP), the site immediately proximal to the HBBP as the HB, and the site immediately distal to the HBBP as the RBB.
Results: The HBBP was identified in all patients. In all cases but one patient, the H-V interval measured at the HB adjacent to the HBBP was ≥35 ms. However, in 12 patients, the H-V interval measured at the RBB adjacent to the HBBP was also ≥35 ms.
Conclusions: The electrophysiologic identification of HB versus RBB by simultaneous recordings of HB and RBB potentials during induction of the V3 phenomenon was feasible. When the discrimination between HB and RBB was based on the measurement of the H-V interval, the proximal portion of the RBB was frequently misidentified as the HB. 相似文献
10.
Yuko SENBA Kenshiro TSUDA Haruhiko MARUYAMA Ichiro KUROKAWA Hitoshi MIZUTANI Yoshiki TANIGUCHI 《The Journal of dermatology》2009,36(2):86-89
We report a case of creeping disease treated successfully with ivermectin. A 46-year-old man presented with a 1-month history of pruriginous linear erythema on his right thigh after a visit to Indonesia. Although he had no history of eating raw fish or meat, he walked along the river and in the jungle without wearing shoes. Creeping disease caused by animal hookworm was strongly suspected. The presence of parasite larvae was not confirmed in biopsied skin specimens. In enzyme-linked immunosorbent assay, serum samples were negative for binding to hookworm antigens, including Ancylostoma canium , Necator americanus and Gnathostoma doloresi . He was treated with a single 12 mg oral dose (200 µg/kg) of ivermectin. The eruption and pruritus resolved within a few days after the administration and did not relapse. 相似文献