全文获取类型
收费全文 | 126篇 |
免费 | 5篇 |
专业分类
儿科学 | 14篇 |
基础医学 | 13篇 |
口腔科学 | 8篇 |
临床医学 | 11篇 |
内科学 | 49篇 |
神经病学 | 4篇 |
特种医学 | 2篇 |
外科学 | 21篇 |
预防医学 | 7篇 |
眼科学 | 1篇 |
药学 | 1篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2014年 | 3篇 |
2013年 | 6篇 |
2012年 | 12篇 |
2011年 | 7篇 |
2010年 | 4篇 |
2009年 | 2篇 |
2008年 | 1篇 |
2007年 | 7篇 |
2006年 | 8篇 |
2005年 | 6篇 |
2004年 | 7篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有131条查询结果,搜索用时 31 毫秒
1.
Massa O Iafusco D D'Amato E Gloyn AL Hattersley AT Pasquino B Tonini G Dammacco F Zanette G Meschi F Porzio O Bottazzo G Crinó A Lorini R Cerutti F Vanelli M Barbetti F;Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology Diabetology 《Human mutation》2005,25(1):22-27
Permanent neonatal diabetes mellitus (PNDM) is a rare condition characterized by severe hyperglycemia constantly requiring insulin treatment from its onset. Complete deficiency of glucokinase (GCK) can cause PNDM; however, the genetic etiology is unknown in most PNDM patients. Recently, heterozygous activating mutations of KCNJ11, encoding Kir6.2, the pore forming subunit of the ATP-dependent potassium (K(ATP)) channel of the pancreatic beta-cell, were found in patients with PNDM. Closure of the K(ATP) channel exerts a pivotal role in insulin secretion by modifying the resting membrane potential that leads to insulin exocytosis. We screened the KCNJ11 gene in 12 Italian patients with PNDM (onset within 3 months from birth) and in six patients with non-autoimmune, insulin-requiring diabetes diagnosed during the first year of life. Five different heterozygous mutations were identified: c.149G>C (p.R50P), c.175G>A (p.V59M), c.509A>G (p.K170R), c.510G>C (p.K170N), and c.601C>T (p.R201C) in eight patients with diabetes diagnosed between day 3 and 182. Mutations at Arg50 and Lys170 residues are novel. Four patients also presented with motor and/or developmental delay as previously reported. We conclude that KCNJ11 mutations are a common cause of PNDM either in isolation or associated with developmental delay. Permanent diabetes of non autoimmune origin can present up to 6 months from birth in individuals with KCNJ11 and EIF2AK3 mutations. Therefore, we suggest that the acronym PNDM be replaced with the more comprehensive permanent diabetes mellitus of infancy (PDMI), linking it to the gene product (e.g., GCK-PDMI, KCNJ11-PDMI) to avoid confusion between patients with early-onset, autoimmune type 1 diabetes. 相似文献
2.
Schultheiss D Hiltl DM Meschi MR Machtens SA Truss MC Stief CG Jonas U 《World journal of urology》2000,18(6):431-435
Androgens influence important central and peripheral mechanisms of the erectile system. The relevance of a moderate decrease
of serum testosterone level for erectile dysfunction (ED) has not been clarified so far. The aim of our study was to offer
an easy transcutaneous method of androgen application. A previous study on the pharmacokinetic profile of the testosterone
gel applied, showed marked elevation of the serum levels of testosterone. In our study, 46 hypogonadal patients with ED and
total lack of vaginal penetration applied testosterone gel (4 mg/day; supplied by Azupharma, Germany) to the penile skin twice
a day over 6–8 weeks, after a run-in period with placebo gel of 2 weeks. All patients showed decreased testosterone serum
levels (<3 ng/ml) in at least two morning samples over a period of 3 weeks before treatment. Psychogenic etiology was excluded
by a sexual psychologist. Patient age was 37–69 years (mean 53.5). Three patients (6.5%) responded to placebo in the run-in
phase and were withdrawn from further treatment. Fifteen patients (32.6%) showed improved erection, allowing penetration and
sexual intercourse. Twenty-eight patients (60.9%) did not respond to therapy. Local genital skin irritation was not observed.
Elevation of peripheral testosterone was not correlated to a positive therapy response. A success-rate of 32.6% in this group
of patients after exclusion of psychogenic patients and placebo-responders seems to justify further investigations. A medication
period of 6–8 weeks is most probably too short to induce imaginable regenerative effects of testosterone on the erectile system.
We therefore suggest that future double-blind and placebo-controlled studies should be designed for a minimum of 3 months.
Testosterone gel may be a cost effective form of androgen administration. 相似文献
3.
Vanelli M Cerutti F Chiarelli F Lorini R Meschi F;MCDC-Italy Group 《Journal of endocrinological investigation》2005,28(8):692-699
Clinical characteristics and metabolic control in a large cohort of children with Type 1 diabetes (T1DM) were evaluated. Fifty-three Italian centers for childhood diabetes collected blood samples and clinical records from 3560 consecutive eligible patients aged 1.6-17.10 yr with disease duration >12 months. HbA1c determinations were centralized in a Diabetes Control and Complications Trial-controlled laboratory. HbA1c grand mean was 8.87 +/- 1.77%. Thirty-two percent of the patients had HbA1c values <8.0%. Puberty and disease duration were the main determinants of increase in HbA1c levels (<0.001). HbA1c values were inversely correlated to the frequency of blood glucose monitoring (p<0.001). Among the total population, 53.7% of the patients had 4 or more injections per day, 37.8% three injections, 7.4% < or =2 injections and only 1.1% was on pumps. Daily number of injections increased with age (p<0.001). Hypoglycemia episodes were reported in 17.6% patient-years and diabetic ketoacidosis (DKA) in 1.0% of children, more frequently in those with HbA1c >8.8% (p<0.02). Two thirds of Italian children with T1DM have HbA1c>8% despite regionalized centers, multidisciplinary team approach, free access to appropriate diabetes care, education, frequent blood glucose monitoring and multiple insulin injections. 相似文献
4.
Meschi Nastaran Vanhoenacker Anke Strijbos Olaf Camargo dos Santos Bernardo Rubbers Eléonore Peeters Valerie Curvers Frederik Van Mierlo Maarten Geukens Arne Fieuws Steffen Verbeken Eric Lambrechts Paul 《Clinical oral investigations》2020,24(12):4439-4453
Clinical Oral Investigations - The aim of this study was to assess in a multi-modular manner the bone healing 1 year post root-end surgery (RES) with leukocyte- and platelet-rich fibrin... 相似文献
5.
6.
7.
Francesco Vairo Emanuele Nicastri Salma Masauni Yussuf Angela Cannas Silvia Meschi Mwanakheir AA Mahmoud Azza H. Mohamed Paul Mohamed Maiko Pasquale De Nardo Nazario Bevilacqua Concetta Castilletti Antonino Di Caro Vincenzo Racalbuto Giuseppe Ippolito 《Emerging infectious diseases》2014,20(3):465-468
We conducted a seroprevalence survey among 500 healthy adult donors at Zanzibar National Blood Transfusion Services. Dengue virus IgG seroprevalence was 50.6% and independently associated with age and urban residence. These data will aid in building a surveillance, preparedness, and response plan for dengue virus infections in the Zanzibar Archipelago.Key words: dengue, seroprevalence, Zanzibar, viruses, vector-borne infections 相似文献
8.
Meschi T Schianchi T Ridolo E Adorni G Allegri F Guerra A Novarini A Borghi L 《Urologia internationalis》2004,72(Z1):29-33
Nutrition plays a major role in the pathogenesis of the most widespread forms of nephrolithiasis, i.e. calcium (calcium oxalate and phosphate) and uric acid stone disease. For this reason, dietary measures are the first level of intervention in primary prevention, as well as in secondary prevention of recurrences. An unbalanced diet or particular sensitivity to various foods in stone formers can lead to urinary alterations such as hypercalciuria, hyperoxaluria, hyperuricosuria, hypocitraturia and an excessively acid urinary pH. Over the course of time, these conditions contribute to the formation or recurrence of kidney stones, due to the effect they exert on the lithogenous salt profile. The fundamental aspects of the nutritional approach to the treatment of idiopathic nephrolithiasis are body weight, diet and water intake. This paper will present data resulting from our own investigations and the most significant evidence in literature. 相似文献
9.
10.