全文获取类型
收费全文 | 1734篇 |
免费 | 79篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 74篇 |
妇产科学 | 44篇 |
基础医学 | 173篇 |
口腔科学 | 57篇 |
临床医学 | 171篇 |
内科学 | 439篇 |
皮肤病学 | 110篇 |
神经病学 | 51篇 |
特种医学 | 224篇 |
外科学 | 184篇 |
综合类 | 35篇 |
一般理论 | 1篇 |
预防医学 | 117篇 |
眼科学 | 6篇 |
药学 | 45篇 |
中国医学 | 3篇 |
肿瘤学 | 63篇 |
出版年
2019年 | 13篇 |
2018年 | 11篇 |
2017年 | 18篇 |
2016年 | 20篇 |
2015年 | 26篇 |
2014年 | 31篇 |
2013年 | 83篇 |
2012年 | 39篇 |
2011年 | 34篇 |
2010年 | 55篇 |
2009年 | 62篇 |
2008年 | 46篇 |
2007年 | 47篇 |
2006年 | 52篇 |
2005年 | 49篇 |
2004年 | 33篇 |
2003年 | 24篇 |
2002年 | 32篇 |
2001年 | 32篇 |
2000年 | 24篇 |
1999年 | 32篇 |
1998年 | 86篇 |
1997年 | 79篇 |
1996年 | 81篇 |
1995年 | 59篇 |
1994年 | 69篇 |
1993年 | 52篇 |
1992年 | 20篇 |
1991年 | 26篇 |
1990年 | 27篇 |
1989年 | 47篇 |
1988年 | 52篇 |
1987年 | 35篇 |
1986年 | 33篇 |
1985年 | 32篇 |
1984年 | 29篇 |
1983年 | 14篇 |
1982年 | 27篇 |
1981年 | 21篇 |
1980年 | 18篇 |
1979年 | 26篇 |
1978年 | 23篇 |
1977年 | 22篇 |
1976年 | 21篇 |
1975年 | 16篇 |
1974年 | 11篇 |
1973年 | 20篇 |
1972年 | 14篇 |
1970年 | 14篇 |
1969年 | 10篇 |
排序方式: 共有1846条查询结果,搜索用时 15 毫秒
1.
A. Cagnin M. Kassiou S. R. Meikle R. B. Banati 《Acta neurologica Scandinavica》2006,114(S185):107-114
2.
3.
Infantile Digital Fibroma Treated With Mohs Micrographic Surgery 总被引:2,自引:0,他引:2
John G. Albertini MD Maj USAF MC Michael Jude Welsch MD CPT USA MC Leo A. Conger MD LTC USA MC Lester F. Libow MD COL USA MC Dirk M. Elston MD COL USA MC 《Dermatologic surgery》2002,28(10):959-961
BACKGROUND: Infantile digital fibroma (IDF) is a rare benign fibrous tumor of childhood that frequently recurs despite local excision. Conservative, nonsurgical management may result in regression and/or joint deformity. OBJECTIVE: To describe the histologic features of IDF and discuss a case excised using Mohs micrographic surgery (MMS). METHODS: Case report and review of the clinical, histologic, and ultrastructural features. RESULTS: Characteristic inclusion bodies of actin were identified with hematoxylin and eosin, Masson's trichrome, and rapid actin immunostain. The tumor was debulked and the majority was removed after one stage of MMS, except where the deep margin approached the joint space. The defect healed by secondary intention. At 2 years the patient had no recurrence or functional joint deformity. CONCLUSION: MMS is a surgical treatment option for IDF. 相似文献
4.
Andrew Meikle Davison 《Forensic science, medicine, and pathology》2009,5(2):90-94
A 62-year-old male with no significant medical history developed thromboembolic complications in the lower limbs shortly after
an assault which involved punching and kicking to the trunk. Laparotomy revealed intra-abdominal injuries and an abdominal
aortic aneurysm. Death from multi-organ failure and sepsis occurred 9 days post-injury. The discussion concentrates on blunt
force trauma to the abdominal aorta, specifically on causation, mechanisms of injury and complications. 相似文献
5.
Much of the connective tissue degradation that takes place in periodontal diseases is mediated by proteolytic enzymes. Previous studies have focused on the action of proteinases released by invading polymorphonuclear neutrophils and macrophages, and bacterial enzymes. In view of recent work establishing that resident connective tissue cells can be induced by cytokines to bring about the destruction of their own matrix, we propose a new hypothesis. In this we envisage that a critical step is the interaction of bacterial antigens with inflammatory cells, resulting in the production of a cytokine, interleukin-1. Our interpretation of in vitro evidence is that the loss of connective tissue attachment and bone matrix resorption in periodontal diseases is mediated by metalloproteinases such as collagenase and stromelysin released by cells of the periodontium. Such proteolytic destruction can be induced by interleukin-1, whose production may not be dependent on a specific microbial flora but may be triggered by a number of organisms. It is now clear that interleukin-1 has multiple actions on both immune and non-immune cells; these include the induction of lymphocyte differentiation and proliferation and the stimulation of bone and cartilage resorption, and prostaglandin and metalloproteinase synthesis by connective tissues. It seems likely that further knowledge about the production and function of this cytokine will have an increasing impact in many diseases that involve resorption, particularly since interleukin-1-like molecules can be produced by cell types other than monocytes/macrophages, including keratinocytes and fibroblasts. 相似文献
6.
HJ Aubin S Tilikete C Laureaux HT Nguyen Hac MC Roullet-Volmi S Troupel D Barrucand 《European psychiatry》1995,10(8)
The aim of this study was to assess alcoholic inpatients' smoking and coffee intake variation following withdrawal. Only moderate smokers (less than 30 cigarettes/day) showed a significant increase of cigarette consumption after alcohol withdrawal. However, their urinary cotinine level did not vary, suggesting a behavioral, and not biological, compensation through smoking following alcohol withdrawal. Heavy smokers (30 cigarettes/day or more) showed no significant clinical or biological variation of smoking behavior. Coffee consumption increased after alcohol withdrawal in all patients, irrespective of smoking habits. 相似文献
7.
Xian ZH Zhang SH Cong WM Wu WQ Wu MC 《第二军医大学学报》2005,26(11):1320-1320
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent fatal cancers in the world. Despite advances in early diagnosis and improvements in surgical techniques, the survival of patients with HCC even after resection is poor because of the high incidence of recurrences. Therefore, the identification of prognostic factors may be helpful in the development of new treatment protocols. AIMS: To investigate HER-2/neu status in HCC by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and to explore the possibility of using trastuzumab in the treatment of HCC. METH ODS: Eight hundred and sixty eight surgical samples from patients with primary HCC were examined for their HER-2/neu status. IHC for HER-2/neu was performed with the HercepTest kit; FISH analysis was performed with the PathVysion HER-2 DNA probe kit. The correlations between HER-2/neu overexpression and clinicopathological characteristics were analysed statistically. RESULTS: HER-2/neu overexpression was detected in 21 (2.42%) of the 868 primary HCCs. Only one specimen showed HER-2/neu gene amplification by FISH. No significant associations were found between HER-2/neu overexpression and the clinicopathological parameters. CONCLUSIONS: There is a low frequency of HER-2/neu overexpression/amplification in HCC. There appears to be no role for HER-2/neu as a prognostic marker and no benefit of anti-HER-2/neu trastuzumab treatment in patients with HCC. 相似文献
8.
MC Brouard P Chavaz L Borradori 《Journal of the European Academy of Dermatology and Venereology》2004,18(1):89-92
BACKGROUND: Bowel-associated dermatosis-arthritis syndrome denotes the occurrence of diarrhoea with arthritis and skin lesions related to bowel disease with or without bowel bypass. In this condition, the histological finding of cutaneous aseptic neutrophilic cell infiltrate is non-specific and common to a wide spectrum of neutrophilic dermatoses, including pyoderma gangrenosum. OBSERVATION: We describe a 78-year-old woman with fever, abdominal discomfort and arthralgias, who developed grouped pustular lesions on her shins with histologically spongiform pustule formation. Aetiological assessment disclosed diverticular disease with sigmoid stenosis. CONCLUSION: Although clinical and histological features in our case fit the diagnosis of bowel-associated dermatosis-arthritis syndrome, they may also correspond to a pustular variant of pyoderma gangrenosum. Our observation raises the question of the nosological classification of bowel-associated dermatosis-arthritis syndrome within the spectrum of neutrophilic diseases. 相似文献
9.
P S Withington T R Graham R J Meikle A Allan M T Marrinan C T Lewis 《Journal of medical engineering & technology》1991,15(2):68-71
The development of implantable left ventricular assist devices (LVADs) has almost reached the stage of providing permanent circulatory support in patients who are unsuitable for, or denied, the transplant option. As part of our ongoing haemodynamic evaluation of the Thermo Cardiosystems Inc. (Boston, USA) Mark 14 pneumatic LVAD, pressure-volume loops have been produced from in vitro studies using a modified National Heart Lung and Blood Institute (NHLBI, USA) mock circulatory loop. These studies have demonstrated that during certain phases of the pump cycle non-physiologically high and low pressures are generated within the LVAD. Such abnormal pressures may damage either the bioprosthetic valves in the LVAD or the native heart, and may have adverse effects on cardiovascular control mechanisms. 相似文献
10.