全文获取类型
收费全文 | 124篇 |
免费 | 11篇 |
专业分类
儿科学 | 3篇 |
基础医学 | 20篇 |
口腔科学 | 1篇 |
临床医学 | 21篇 |
内科学 | 32篇 |
皮肤病学 | 2篇 |
神经病学 | 3篇 |
特种医学 | 2篇 |
外科学 | 26篇 |
综合类 | 3篇 |
眼科学 | 7篇 |
药学 | 7篇 |
中国医学 | 1篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 6篇 |
2022年 | 5篇 |
2021年 | 12篇 |
2020年 | 9篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 5篇 |
2015年 | 9篇 |
2014年 | 7篇 |
2013年 | 2篇 |
2012年 | 16篇 |
2011年 | 3篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 4篇 |
2005年 | 5篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
排序方式: 共有135条查询结果,搜索用时 15 毫秒
1.
Christine M. Lin Ronald G. Gill Borna Mehrad 《American journal of transplantation》2021,21(11):3550-3560
Chronic rejection is among the most pressing clinical challenges in solid organ transplantation. Interestingly, in a mouse model of heterotopic heart transplantation, antibody-dependent, natural killer (NK) cell-mediated chronic cardiac allograft vasculopathy occurs in some donor–recipient strain combinations, but not others. In this study, we sought to identify the mechanism underlying this unexplained phenomenon. Cardiac allografts from major histocompatibility complex (MHC) mismatched donors were transplanted into immune-deficient C57Bl/6.rag−/− recipients, followed by administration of a monoclonal antibody against the donor MHC class I antigen. We found marked allograft vasculopathy in hearts from C3H donors, but near-complete protection of BALB/c allografts from injury. We found no difference in recipient NK cell phenotype or intrinsic responsiveness to activating signals between recipients of C3H versus BALB/c allografts. However, cardiac endothelial cells from C3H allografts showed an approximately twofold higher expression of Rae-1, an activating ligand of the NK cell receptor natural killer group 2D (NKG2D). Importantly, the administration of a neutralizing antibody against NKG2D abrogated the development of allograft vasculopathy in recipients of C3H allografts, even in the presence of donor-specific antibodies. Therefore, the activating NK cell receptor NKG2D is necessary in this model of chronic cardiac allograft vasculopathy, and strain-dependent expression of NK activating ligands correlates with the development of this disease. 相似文献
2.
Mehrdad Asadifar Malectaj Yazdani Ramin Sadeghpour Chris Bruno Jeffrey Green Andrew T Nakamoto Pegah Hosseini Farahnaz Fahami Sheila Gottschalk Tetsuo Nakamoto 《Food and chemical toxicology》2005,43(3):451-456
We hypothesized that the pathological effects on the neonatal rat heart could be aggravated by Cu deficiency due to the combined effects of caffeine exposure and malnutrition. Upon birth, pups were mixed and randomly picked; 8 pups were assigned to each dam and then divided into 4 groups. Group 1 dams received a normal diet containing 20% protein. Group 2 dams were fed 20% protein diet supplemented with caffeine (4 mg/100 g BW). Group 3 dams received 6% protein diet as a malnourished group, and group 4 dams received 6% protein diet supplemented with caffeine (4 mg/100 g BW). On postnatal day 10, dams and pups were killed. Group 2 tended to have a decrease in the Cu levels of dams' plasma and milk and in pups' plasma and heart tissue compared to those of group 1. This pattern was not observed consistently between groups 3 and 4. Transmission electron microscopy of group 2 pups' hearts revealed a degree of disruption in the mitochondria compared to normal mitochondria seen in group 1. There was no consistent change in the mitochondria of group 4 compared to group 3. The caffeine level observed in all categories of group 4 (dams' plasma and milk, pups' plasma and heart tissue) was lower than those in group 2. Although malnutrition affected body weight and heart weight, combined effects of caffeine and malnutrition on Cu content in the neonatal heart was relatively minor compared to the well nourished group. This well nourished group showed that the effects of caffeine on Cu were more consistent, resulting the changes of mitochondria. 相似文献
3.
Assessment of left and right ventricular rotational interdependence: A speckle tracking echocardiographic study
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
Majid Nimrouzi Omid Sadeghpour Mohammad Hadi Imanieh Mohammadreza Shams Ardekani Alireza Salehi Mohamad Bagher Minaei Mohammad M. Zarshenas 《Iranian journal of pediatrics.》2015,25(2)
Background:
Polyethylene glycol (PEG) is often considered as the first-line treatment for functional constipation in children. Descurainia sophia (L.) Webb et Berth (D. sophia) is a safe recommended medicine in Iranian folk and Traditional Persian Medicine for the treatment of constipation.Objectives:
To clinically compare D. sophia with PEG 4000 (without electrolyte) in pediatric constipation and to assess its efficacy and side effects.Patients and Methods:
120 patients aged 2 - 12 years with constipation for at least 3 months were included in an 8 weeks lasting randomized controlled trial within two parallel-groups. Children received either PEG, 0.4 g/kg/day, or D. sophia seeds, 2 grams (for children aged 2 - 4 years) and 3 grams (for those aged > 4 years) per day.Results:
A total of 109 patients completed the study (56 in D. sophia and 53 in PEG group). At the end of the study, 36 (64.3%) patients in D. sophia group and 29 (54.7%) in PEG group were out of Rome III criteria (P = 0.205). Median weekly stool frequency in 0, 1, 2, 3 weeks of the treatment was found to be 2, 5, 5, 5 in D. sophia and 3, 4, 4, 5 in PEG group (P = 0.139, 0.076, 0.844, 0.294), respectively. The number of patients who suffered flatulence was less (5, 8.9%) in D. sophia group as compared to PEG group (6, 11.3%) at the end of the trial (P = 0.461). D. sophia taste was less tolerated.Conclusions:
D. sophia is introduced as a cheap and available medication which can be applied as a safe alternative to conventional PEG in the management of pediatric chronic functional constipation. 相似文献5.
Can F. Koyuncu Cheng Lu Kaustav Bera Zelin Zhang Jun Xu Paula Toro German Corredor Deborah Chute Pingfu Fu Wade L. Thorstad Farhoud Faraji Justin A. Bishop Mitra Mehrad Patricia D. Castro Andrew G. Sikora Lester D.R. Thompson R.D. Chernock Krystle A. Lang Kuhs Jingqin Luo Vlad Sandulache David J. Adelstein Shlomo Koyfman James S. Lewis Jr. Anant Madabhushi 《The Journal of clinical investigation》2021,131(8)
BACKGROUNDPatients with p16+ oropharyngeal squamous cell carcinoma (OPSCC) are potentially cured with definitive treatment. However, there are currently no reliable biomarkers of treatment failure for p16+ OPSCC. Pathologist-based visual assessment of tumor cell multinucleation (MN) has been shown to be independently prognostic of disease-free survival (DFS) in p16+ OPSCC. However, its quantification is time intensive, subjective, and at risk of interobserver variability.METHODSWe present a deep-learning–based metric, the multinucleation index (MuNI), for prognostication in p16+ OPSCC. This approach quantifies tumor MN from digitally scanned H&E-stained slides. Representative H&E-stained whole-slide images from 1094 patients with previously untreated p16+ OPSCC were acquired from 6 institutions for optimization and validation of the MuNI.RESULTSThe MuNI was prognostic for DFS, overall survival (OS), or distant metastasis–free survival (DMFS) in p16+ OPSCC, with HRs of 1.78 (95% CI: 1.37–2.30), 1.94 (1.44–2.60), and 1.88 (1.43–2.47), respectively, independent of age, smoking status, treatment type, or tumor and lymph node (T/N) categories in multivariable analyses. The MuNI was also prognostic for DFS, OS, and DMFS in patients with stage I and stage III OPSCC, separately.CONCLUSIONMuNI holds promise as a low-cost, tissue-nondestructive, H&E stain–based digital biomarker test for counseling, treatment, and surveillance of patients with p16+ OPSCC. These data support further confirmation of the MuNI in prospective trials.FUNDINGNational Cancer Institute (NCI), NIH; National Institute for Biomedical Imaging and Bioengineering, NIH; National Center for Research Resources, NIH; VA Merit Review Award from the US Department of VA Biomedical Laboratory Research and Development Service; US Department of Defense (DOD) Breast Cancer Research Program Breakthrough Level 1 Award; DOD Prostate Cancer Idea Development Award; DOD Lung Cancer Investigator-Initiated Translational Research Award; DOD Peer-Reviewed Cancer Research Program; Ohio Third Frontier Technology Validation Fund; Wallace H. Coulter Foundation Program in the Department of Biomedical Engineering; Clinical and Translational Science Award (CTSA) program, Case Western Reserve University; NCI Cancer Center Support Grant, NIH; Career Development Award from the US Department of VA Clinical Sciences Research and Development Program; Dan L. Duncan Comprehensive Cancer Center Support Grant, NIH; and Computational Genomic Epidemiology of Cancer Program, Case Comprehensive Cancer Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, the US Department of VA, the DOD, or the US Government. 相似文献
6.
Lawsone (2-hydroxynaphthalene-1,4-dione) is a natural product which shows significant biological activity. Aminomethylnaphthoquinone Mannich bases derived from lawsone constitute an interesting class of naphthoquinones and/or their metal complexes have demonstrated a series of important biological properties. So, this review aimed to document the publications concerning the synthesis of aminomethylnaphthoquinone Mannich bases from lowsone, aldehydes and amines and their metal complexes using different conditions, and investigation of their applications.Lawsone (2-hydroxynaphthalene-1,4-dione) is a natural product which shows significant biological activity. 相似文献
7.
8.
Morteza Ghasemnejad-Berenji Sarvin Pashapour Sonia Sadeghpour 《Medical principles and practice》2021,30(1):98
In December 2019, a new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China, causing pneumonia outbreaks first in the Wuhan region and has now spread worldwide. There are no specific drugs for the disease caused by this virus, coronavirus disease 2019 (COVID-19). Considering that new synthesized drugs cannot be applied immediately to patients, conventional drug in new use is a feasible solution. Chloroquine, remdesivir, favipiravir, lopinavir, ribavirin, and ritonavir have shown efficacy to inhibit coronavirus in vitro. Pentoxifylline, a drug with anti-inflammatory, immunomodulatory, and bronchodilatory effects, has previously been shown to inhibit several viral infections. Immunological studies have shown that most patients with severe COVID-19 exhibit substantially elevated serum levels of pro-inflammatory cytokines. Pentoxifylline is a phosphodiesterase inhibitor that increases the levels of cyclic adenosine monophosphate, which in turn activates protein kinase, leading to a reduction in the synthesis of pro-inflammatory cytokines and immune cell migration. Here, we propose pentoxifylline, a drug with low cost and toxicity, as a possible treatment for COVID-19 based on its interesting properties. 相似文献
9.
10.
Mohammadrafie Khorgami Ali Sadeghpour Tabaei Elio Caruso Silvia Farruggio Negar Omidi Maryam Moradian Behzad Mohammadpour Ahranjani Zahra Khajali Rahele Zamani 《Congenital heart disease》2021,16(6):573-584
Background: Most children in need of cardiac pacemakers remain dependent on the function of the permanent
from childhood to adulthood. We sought to evaluate and compare the function between epicardial and endocardial
pacemakers in pediatric groups with different conditions. Methods: Between 2012 and 2018, this single-canter study
evaluated 44 pediatric patients with indications for epicardial or endocardial pacemakers. Results: The 2 groups, at a
median age of 5 (0.1–16) years, were compared concerning the characteristics of the leads used (n = 80: bipolar,
unipolar, steroid-eluting, and non–steroid-eluting), survival data, and complications. The reason for pacemaker
implantation was congenital complete heart block in 11 (25%) cases and postoperative heart block in 33 (75%) cases.
The commonest congenital heart disease accompanied by postoperative block was the ventricular septal defect. In
the endocardial lead group, the mean ventricular pacing threshold immediately after the implantation and during
the follow-up was less than that in the epicardial lead group (0.75 vs. 0.81 V; P = 0.01 and 0.8 vs. 2.4 V; P = 0.001).
During the follow-up, the mean battery longevity was better in the endocardial group (last visit: 6.7 endocardial vs.
3.3 years epicardial). Lead failure was commoner in the epicardial pacemaker, and chronic high-pacing threshold
pattern was seen in 14 patients in this group. After 3 years, freedom from lead failure was 94% and 63% in the
endocardial and epicardial leads. Conclusions: Pacemakers with endocardial bipolar steroid-eluting leads showed
better lead characteristics regarding survival and battery longevity than epicardial pacemakers without these lead
characteristics. An appropriate pacemaker type should be selected based on the patient’s condition. 相似文献