全文获取类型
收费全文 | 298篇 |
免费 | 14篇 |
专业分类
耳鼻咽喉 | 5篇 |
基础医学 | 42篇 |
口腔科学 | 78篇 |
临床医学 | 16篇 |
内科学 | 49篇 |
皮肤病学 | 2篇 |
神经病学 | 13篇 |
特种医学 | 11篇 |
外科学 | 52篇 |
综合类 | 2篇 |
预防医学 | 27篇 |
药学 | 9篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 2篇 |
2022年 | 6篇 |
2021年 | 6篇 |
2020年 | 6篇 |
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 7篇 |
2012年 | 18篇 |
2011年 | 16篇 |
2010年 | 9篇 |
2009年 | 5篇 |
2008年 | 11篇 |
2007年 | 9篇 |
2006年 | 12篇 |
2005年 | 15篇 |
2004年 | 12篇 |
2003年 | 11篇 |
2002年 | 13篇 |
2001年 | 5篇 |
2000年 | 12篇 |
1999年 | 9篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 7篇 |
1986年 | 2篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1974年 | 2篇 |
排序方式: 共有312条查询结果,搜索用时 31 毫秒
1.
Antihypertensive effect of beta blockade in renal transplant recipients with or without host kidneys
Host kidneys may contribute considerably to hypertension after renal transplantation. Their role in sustaining hypertension is more prominent if glomerulonephritis (GN) than if interstitial nephritis (IN) is the original renal disease. We compared the antihypertensive effect of beta-blockade in IN (n = 10) and GN (n = 19) hypertensive renal transplant recipients with host kidneys in situ with those who had undergone bilateral nephrectomy (BN, n = 10). Pretreatment blood pressures were comparable in BN, IN, and GN patients, being 165 +/- 6/108 +/- 3, 172 +/- 5/104 +/- 3, and 161 +/- 3/104 +/- 1, mmHg, respectively. Blood pressure did not change on beta-blockade in BN patients, whereas it decreased significantly more (P less than 0.001) in GN than in IN patients, changes of mean arterial pressure being -107 +/- 1.0, -14.9 +/- 1.3, and -6.8 +/- 1.6%, respectively. This failure to respond to beta-blockade in patients without host kidneys may be related to low activity of the renin-angiotensin system or to functional denervation of the grafted kidney. Further investigations of this phenomenon may clarify the mechanism of antihypertensive action of beta-blockade as well as the nature of hypertension after renal transplantation. 相似文献
2.
3.
Assessment of hypertrophy in myocardial biopsies taken during correction of congenital heart disease
A J Bogers A van der Laarse H W Vliegen J M Quaegebeur L Hollaar J M Egas C J Cornelisse J Rohmer H A Huysmans 《The Thoracic and cardiovascular surgeon》1988,36(3):137-140
Myocardial biopsies were obtained from 27 patients undergoing corrective cardiac surgery for congenital heart disease. Normal hearts of 18 autopsied patients were used as reference. The biopsy material was assessed for desoxyribonucleic acid (DNA) concentration and ploidy profile of cell nuclei in order to quantitate myocardial hypertrophy at the time of operation. DNA-concentration decreased significantly with age (r = -0.76; p less than 0.001). Ploidy profile of myocardial nuclei correlated with age: the relative number of diploid nuclei decreased (r = -0.67; p less than 0.001), the relative numbers of tetraploid and octoploid nuclei increased with age (r = 0.58; p less than 0.01 and r = 0.77; p less than 0.001 respectively). At 8 years of age the patients with congenital heart disease reached myocardial DNA-concentrations comparable with those in normal adult hearts. At higher age the patients with congenital heart disease exceeded normal adult values for myocardial DNA-concentration. These findings are interpreted to represent rapid development of hypertrophy with an early onset, reaching at 8 years of age values observed in normal adult hearts. Quantitation of myocardial hypertrophy by DNA-concentration and ploidy profile of nuclei may offer a means to explain some of the factors of influence on the outcome of corrective cardiac surgery for congenital heart disease in relation to its timing. Our data stress the need for preventing irreversible myocardial damage by timely (surgical) therapy. 相似文献
4.
5.
Schaap R. Schaafsma F. G. Huysmans M. A. Bosma A. R. Boot C. R. L. Anema J. R. 《Journal of occupational rehabilitation》2022,32(3):438-451
Journal of Occupational Rehabilitation - Purpose Health problems among employees with a lower socioeconomic position (SEP) often result from an interplay of problems on multiple life domains.... 相似文献
6.
Deijkers RL Bouma GJ van der Meer-Prins EM Huysmans PE Taminiau AH Claas FH 《The Journal of bone and joint surgery. British volume》1999,81(3):538-544
We analysed the cellular immune response in ten transplantations of different massive bone allografts, of which five had a poor clinical outcome. Cytotoxic T lymphocytes (CTL) and T helper lymphocytes (TH) against mismatched donor antigens were found in all patients. More importantly, CTL with a high affinity for donor antigens were found in five cases. High-affinity CTL need no CD8 molecule to stabilise the antigen binding and are strongly associated with rejection of heart and corneal transplants. Even after removal of most of the bone-marrow cells, we found high-affinity CTL and high TH frequencies. This T-cell response could be detected over a period of years. We conclude that frozen bone allografts can induce high-affinity donor-specific CTL. The present assay allows qualification and quantification of the levels of CTL and TH in the blood. This approach may be helpful in studying the effect of the immune response on the outcome of the graft. 相似文献
7.
Blood pressure and proteinuria are important determinants of progressive renal failure in patients with renal diseases. In a 53-year-old man with hypertension and nephrotic-range proteinuria, lowering the blood pressure to a value of 125/75 mmHg resulted in a disappearance of the proteinuria. Recent literature data indicate that the treatment of blood pressure in patients with proteinuria, with emphasis on the benefits of reaching a blood pressure target of 125/75 mmHg and the use of angiotensin-converting enzyme inhibitors, may lead to a serious improvement in their prognosis. 相似文献
8.
Bart Cillekens Maaike A Huysmans Andreas Holtermann Willem van Mechelen Leon Straker Niklas Krause Allard J van der Beek Pieter Coenen 《Scandinavian journal of work, environment & health》2022,48(2):86
ObjectivesEmerging evidence suggests contrasting health effects for leisure-time and occupational physical activity. In this systematic review, we synthesized and described the epidemiological evidence regarding the association between occupational physical activity and cardiovascular disease (CVD) mortality.MethodsA literature search was performed in PubMed, Embase, CINAHL, PsycINFO and Evidence-Based Medicine Reviews, from database inception to 17 April 2020. Articles were included if they described original observational prospective research, assessing the association between occupational physical activity and CVD mortality among adult workers. Reviews were included if they controlled for age and gender and at least one other relevant variable. We performed meta-analyses on the associations between occupational physical activity and CVD mortality.ResultsWe screened 3345 unique articles, and 31 articles (from 23 studies) were described in this review. In the meta-analysis, occupational physical activity showed no significant association with overall CVD mortality for both males [hazard ratio (HR) 1.00, 95% confidence interval (CI) 0.87–1.15] and females (HR 0.95, 95% CI 0.82–1.09). Additional analysis showed that higher levels of occupational physical activity were non-significantly associated with a 15% increase in studies reporting on the outcome ischemic heart disease mortality (HR 1.15, 95% CI 0.88–1.49).ConclusionsWhile the beneficial association between leisure-time physical activity and CVD mortality has been widely documented, occupational physical activity was not found to have a beneficial association with CVD mortality. This observation may have implications for our appreciation of the association between physical activity and health for workers in physically demanding jobs, as occupational physical activity may not be health enhancing. 相似文献
9.
10.
H P de Haan H A Huysmans H W Weeda H A Bosker B Buis 《The Thoracic and cardiovascular surgeon》1985,33(1):55-56
A patient with a pseudoaneurysm at the site of the distal anastomosis of a saphenous vein coronary bypass graft is described. The aneurysm was resected. To our knowledge this is the first report of this complication after coronary bypass surgery. 相似文献