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排序方式: 共有117条查询结果,搜索用时 15 毫秒
1.
Spyridon Chaskis Eva Stachouli Evangelos Gavalas Marianthi Bouzouni Spyros Papaefthymiou 《Materials》2022,15(9)
In the current work, a novel complex concentrated aluminum alloy is designed and studied. In order to investigate the unknown region of the multicomponent phase diagrams, thermo-physical parameters and the CALPHAD method were used to understand the phase formation of the Al58Mg18Zn12Cu5Si7 at.% (Al47.4Mg13.3Zn23.8Cu9.6Si6wt.%) alloy with a low-density of 2.63 g/cm3. The CALPHAD methodology showed good agreement with both the investigated microstructure and the thermodynamic parameters. The designed alloy was manufactured using an induction furnace and pour mold casting process. This study avoids the use of expensive, dangerous or scarce alloying elements and focuses instead on the utilization of widely available relatively cheaper elements. The microstructural evolution as a function of the heat-treatment was studied by means of different microstructural characterization techniques. The hardness, compressive strength and electrical conductivity of the as-cast and heat-treated alloy at room temperature were studied and correlated with the previously characterized microstructure. The alloy is characterized by a multiphase microstructure with major α-Al matrix reinforced with various secondary phases. In terms of mechanical properties, the developed alloy exhibited a high hardness value of 249 Vickers and compressive strength of 588 MPa. The present work provides a valuable insight for researchers, who aim to design and produce industry-like Aluminum based complex concentrated alloys (CCAs). 相似文献
2.
Immunohistochemical localization of interleukin-6 in peripheral human endocrine glands 总被引:2,自引:0,他引:2
Kontogeorgos G Messini I Kyrodimou E Giannikaki L Zois E Koukoulis G Tsagarakis S 《Endocrine》2002,17(2):135-140
Interleukin-6 (IL-6) is a pleiotropic cytokine with differentiation and growth-promoting effects. Extensive studies in experimental
animals denote that IL-6 is produced in various endocrine organs and participates in the local control of endocrine cell function.
The expression of this cytokine in human endocrine glands, however, has only been examined in a limited number of studies.
We investigated the immunohistochemical expression and localization of IL-6 in a variety of peripheral human endocrine glands.
In the adrenals, IL-6 immunoreactivity was detected in all three zones of the cortex. The reticularis and glomerulosa zones
were more heavily stained as compared with the slight immunoreactivity of the fasciculata zone. In the adrenal medulla, chromaffin
and sustentacular cells were variably positive. A substantial number of follicular thyroid cells were strongly immunoreactive
for IL-6 in all normal and hyperplastic thyroids examined. Parafollicular cells were negative. Parathyroid chief cells were
mildly positive; selective and more intense staining was observed in acidophilic cells. Pancreatic islet cells were variably
positive. In the testis positive staining was selectively observed in both Leydig and Sertoli cells. In conclusion, IL-6 immunoreactivity
is present in almost all the human endocrine glands and it expressed in a cell-specific manner. These observations provide
further support for the existence of local immune-endocrine interactions. 相似文献
3.
Maria Sokratous MD Marianthi Breza MD MSc Konstantin Senkevich MD PhD Ziv Gan-Or MD PhD Stefania Kalampokini MD MSc PhD Cleanthi Spanaki MD PhD Antonios Provatas MD PhD Zane Zaunmuktane PhD Varvara Valotassiou MD PhD Panagiotis Georgoulias MD PhD Stephanie Efthymiou Georgios M. Hadjigeorgiou MD PhD Henry Houlden MD PhD Georgia Xiromerisiou MD PhD 《Movement disorders》2021,36(9):2209-2212
4.
5.
Francesco Testa Vittoria Murro Sabrina Signorini Leonardo Colombo Giancarlo Iarossi Francesco Parmeggiani Benedetto Falsini Anna Paola Salvetti Raffaella Brunetti-Pierri Giorgia Aprile Chiara Bertone Agnese Suppiej Francesco Romano Marianthi Karali Simone Donati Paolo Melillo Andrea Sodi Luciano Quaranta Luca Rossetti Luca Buzzonetti Marzio Chizzolini Stanislao Rizzo Giovanni Staurenghi Sandro Banfi Claudio Azzolini Francesca Simonelli 《Investigative ophthalmology & visual science》2022,63(2)
PurposeTo investigate the course of inherited retinal degenerations (IRD) due to mutations in the RPE65 gene.MethodsThis longitudinal multicentric retrospective chart-review study was designed to collect best corrected visual acuity (BCVA), Goldman visual field, optical coherence tomography (OCT), and electroretinography (ERG) measurements. The data, including imaging, were collected using an electronic clinical research form and were reviewed at a single center to improve consistency.ResultsFrom an overall cohort of 60 Italian patients with RPE65-associated IRD, 43 patients (mean age, 27.8 ± 19.7 years) were included and showed a mean BCVA of 2.0 ± 1.0 logMAR. Time-to-event analysis revealed a median age of 33.8 years and 41.4 years to reach low vision and blindness based on BCVA, respectively. ERG (available for 34 patients) showed undetectable responses in most patients (26; 76.5%). OCT (available for 31 patients) revealed epiretinal membranes in five patients (16.1%). Central foveal thickness significantly decreased with age at a mean annual rate of −0.6%/y (P = 0.044). We identified 43 different variants in the RPE65 gene in the entire cohort. Nine variants were novel. Finally, to assess genotype-phenotype correlations, patients were stratified according to the number of RPE65 loss-of-function (LoF) alleles. Patients without LoF variants showed significantly (P < 0.05) better BCVA compared to patients with one or two LoF alleles.ConclusionsWe described the natural course of RPE65-associated IRD in an Italian cohort showing for the first time a specific genotype-phenotype association. Our findings can contribute to a better management of RPE65-associated IRD patients. 相似文献
6.
Xiaoyan Wang Herbert Chase Marianthi Markatou George Hripcsak Carol Friedman 《Journal of biomedical informatics》2010,43(4):595-601
Knowledge acquisition of relations between biomedical entities is critical for many automated biomedical applications, including pharmacovigilance and decision support. Automated acquisition of statistical associations from biomedical and clinical documents has shown some promise. However, acquisition of clinically meaningful relations (i.e. specific associations) remains challenging because textual information is noisy and co-occurrence does not typically determine specific relations. In this work, we focus on acquisition of two types of relations from clinical reports: disease-manifestation related symptom (MRS) and drug-adverse drug event (ADE), and explore the use of filtering by sections of the reports to improve performance. Evaluation indicated that applying the filters improved recall (disease-MRS: from 0.85 to 0.90; drug-ADE: from 0.43 to 0.75) and precision (disease-MRS: from 0.82 to 0.92; drug-ADE: from 0.16 to 0.31). This preliminary study demonstrates that selecting information in narrative electronic reports based on the sections improves the detection of disease-MRS and drug-ADE types of relations. Further investigation of complementary methods, such as more sophisticated statistical methods, more complex temporal models and use of information from other knowledge sources, is needed. 相似文献
7.
Nicholas Townsend Haas Marianthi Ierapetritou Ravendra Singh 《Journal of pharmaceutical innovation》2017,12(2):110-123
In continuous pharmaceutical manufacturing, real-time precise control of critical quality attributes (CQAs) is necessary for quality by design (QbD)-based manufacturing and real-time release (RTR) with minimum consumption of time, space, and resources. Pharmaceutical tablets can be produced through different routes with a common tablet press unit operation always placed at the end of the manufacturing process. Therefore, the tablet press is a crucial unit operation directly influencing the CQAs irrespective of manufacturing routes. Despite this, little attention has been paid to the development of an advanced efficient control system for the tablet press. Process modeling can be used as an efficient virtual experimentation tool to design, compare, and evaluate different control systems. We developed a model in Simulink (Mathworks) that includes two master control loops for tablet weight and hardness and a slave feedback loop controlling the compaction force applied to each tablet. We examined the performance of different control strategies based on proportional integral derivative (PID) control and model predictive control (MPC), as well as feedforward/feedback control. We found that a hybrid MPC-PID control strategy outperforms the PID-only control strategy. We also observed that the addition of a feedforward controller further improves the performance of the hybrid MPC-PID control strategy. 相似文献
8.
9.
Fani Boukouvala Fernando J. Muzzio Marianthi G. Ierapetritou 《Journal of pharmaceutical innovation》2010,5(3):119-137
Introduction
The identification and graphical representation of process design space are critical in locating not only feasible but also optimum operating variable ranges and design configurations. In this work, the mapping of the design space of pharmaceutical processes is achieved using the ideas of process operability and flexibility under uncertainty. 相似文献10.
Primary pleural epithelioid mesothelioma with clear cell morphology is a particularly rare neoplasm, with only a few documented cases. Here, the authors report a case of a 76-year-old man, with a history of asbestos exposure, admitted for mild dyspnea. Radiologic examination revealed right pleural effusion and pleural thickening. Cytological examination of aspirated pleural samples was consistent with non-small cell carcinoma. Histological examination of the resected, via VATS, plural specimens was consistent with the diagnosis of clear cell epithelioid mesothelioma. The authors further analyze the main morphological and immunohistochemical features of clear cell epithelioid mesothelioma, emphasizing the algorithm for excluding other clear cell tumors metastatic to the pleura. 相似文献