全文获取类型
收费全文 | 528篇 |
免费 | 40篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 6篇 |
妇产科学 | 18篇 |
基础医学 | 96篇 |
口腔科学 | 29篇 |
临床医学 | 42篇 |
内科学 | 122篇 |
皮肤病学 | 7篇 |
神经病学 | 51篇 |
特种医学 | 10篇 |
外科学 | 68篇 |
综合类 | 1篇 |
预防医学 | 28篇 |
眼科学 | 5篇 |
药学 | 33篇 |
中国医学 | 1篇 |
肿瘤学 | 51篇 |
出版年
2024年 | 2篇 |
2023年 | 8篇 |
2022年 | 21篇 |
2021年 | 32篇 |
2020年 | 19篇 |
2019年 | 21篇 |
2018年 | 31篇 |
2017年 | 22篇 |
2016年 | 16篇 |
2015年 | 25篇 |
2014年 | 20篇 |
2013年 | 29篇 |
2012年 | 48篇 |
2011年 | 56篇 |
2010年 | 23篇 |
2009年 | 18篇 |
2008年 | 21篇 |
2007年 | 19篇 |
2006年 | 21篇 |
2005年 | 21篇 |
2004年 | 27篇 |
2003年 | 17篇 |
2002年 | 18篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1961年 | 1篇 |
1959年 | 1篇 |
1938年 | 1篇 |
排序方式: 共有572条查询结果,搜索用时 15 毫秒
1.
Ursula R. Kees Jette Ford Pamela R. Ranford Susanne E. Peroni Jaclyn A. Biegel Annette H. Parmiter Lavinia A. Hallam Michael L. N. Willoughby Dominic Spagnolo 《Genes, chromosomes & cancer》1994,9(2):129-135
We have established two cell lines, PER-452 and PER-453, from an 8-month-old girl with an extensive pineoblastoma. Characterization of these lines revealed that the proto-oncogenes MYC and MYCN were not amplified, but both cell lines showed MYCN expression comparable to a cell line with 200-fold MYCN amplification. Both cell lines contained an i( 17q). These results support the concept that pineoblastomas belong to a larger group of primitive neuroectodermal tumors of the central nervous system. These two cell lines provide a unique opportunity to investigate the molecular genetic mechanisms underlying these neoplasms further. Genes Chrom Cancer 9:129-135 (1994).© 1994 Wiley-Liss, Inc. 相似文献
2.
3.
4.
Maja Cigrovski Berkovic Ines Bilic-Curcic Lavinia La Grasta Sabolic Anna Mrzljak Vjekoslav Cigrovski 《World journal of diabetes》2021,12(5):569-577
Hypoglycemia limits optimal glycemic management of patients with type 1 diabetes mellitus (T1DM). Fear of hypoglycemia (FoH) is a significant psycho social consequence that negatively impacts the willingness of T1DM patients to engage in and profit from the health benefits of regular physical activity (e.g., cardiometabolic health, improved body composition, cardiovascular fitness, quality of life). Technological advances, improved insulin regimens, and a better understanding of the physiology of various types of exercise could help ameliorate FoH. This narrative review summarizes the available literature on FoH in children and adults and tools to avoid it. 相似文献
5.
Valentina Mazzotta Alessandro Cozzi Lepri Francesca Colavita Silvia Rosati Eleonora Lalle Claudia Cimaglia Jessica Paulicelli Ilaria Mastrorosa Serena Vita Lavinia Fabeni Alessandra Vergori Gaetano Maffongelli Fabrizio Carletti Simone Lanini Emanuela Caraffa Eugenia Milozzi Raffaella Libertone Pierluca Piselli Enrico Girardi AnnaRosa Garbuglia Francesco Vaia Fabrizio Maggi Emanuele Nicastri Andrea Antinori INMI COVID- Outpatient Treatment Study Group 《Journal of medical virology》2023,95(1):e28186
6.
7.
8.
9.
10.
NF‐κB signaling regulates the generation of intermediate progenitors in the developing neocortex
下载免费PDF全文
![点击此处可从《Genes to cells : devoted to molecular & cellular mechanisms》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Emiko Yamanishi Keejung Yoon Lavinia Alberi Nicholas Gaiano Ken‐ichi Mizutani 《Genes to cells : devoted to molecular & cellular mechanisms》2015,20(9):706-719
In addition to its well‐established role during immune system function, NF‐κB regulates cell survival and synaptic plasticity in the mature nervous system. Here, we show that during mouse brain development, NF‐κB activity is present in the neocortical ventricular and subventricular zones (VZ and SVZ), where it regulates proliferative pool maintenance. Activation of NF‐κB signaling, by expression of p65 or an activated form of the IκB kinase complex subunit IKK2, inhibited neuronal differentiation and promoted retention of progenitors in the VZ and SVZ. In contrast, blockade of the pathway with dominant negative forms of IKK2 and IκBα promoted neuronal differentiation both in vivo and in vitro. Furthermore, by modulating both the NF‐κB and Notch pathways, we show that in the absence of canonical Notch activity, after knockdown of the pathway effector CBF1, NF‐κB signaling promoted Tbr2 expression and intermediate neural progenitor fate. Interestingly, however, activation of NF‐κB in vivo, with canonical Notch signaling intact, promoted expression of the radial glial marker Pax6. This work identifies NF‐κB signaling as a regulator of neocortical neurogenesis and suggests that the pathway plays roles in both the VZ and SVZ. 相似文献