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Borilova Linhartova Petra Deissova Tereza Musilova Kristina Zackova Lenka Kukletova Martina Kukla Lubomir Izakovicova Holla Lydie 《Clinical oral investigations》2018,22(4):1873-1877
Clinical Oral Investigations - The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were... 相似文献
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Vokurka J Klapusová L Pantuckova P Kukletova M Kukla L Holla LI 《Archives of oral biology》2009,54(2):172-117
Objective
Interleukin 18 (IL-18) is shown to be a proinflammatory cytokine that regulates the expression of matrix metalloproteinase 9 (MMP-9). The aim of this study was to test for differences between Czech adolescents with and without gingivitis in relation to MMP-9 and IL-18 polymorphisms.Design
A total of 298 Caucasian children, aged 11-13 years, were examined to assess gingival health. DNA for genetic analysis was obtained from buccal epithelial cells, and the MMP-9 −1562C/T and IL-18 −607A/C variants were identified with PCR-RFLP.Results
Gingivitis was present in 49.3% of the adolescents examined, the rest of the group was considered healthy. The IL-18 −607C and MMP-9 −1562T alleles were found in 58.9% and 8.3% of the healthy subjects, and in 62.2% and 15.0% of the patients with gingivitis, respectively. Although differences in allele frequencies were not significant for IL-18 variant, they were significant for MMP-9 polymorphism (p = 0.01, pcorr < 0.05). Furthermore, a highly significant association of the composite genotype (formed by the variants of the both genes) with gingivitis was found (p = 0.004, pcorr < 0.05).Conclusions
The −1562 T allele of MMP-9 gene could have a role in gingivitis in adolescents. In addition, interaction of the MMP-9 and IL-18 genes could be considered a risk factor for the development of gingivitis in children. 相似文献
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