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排序方式: 共有470条查询结果,搜索用时 15 毫秒
1.
A rat model of monitoring liver allograft rejection 总被引:5,自引:0,他引:5
Timi Martelius Heikki Mäkisalo Krister Höckerstedt Eero Taskinen Irmeli Lautenschlager 《Transplant international》1997,10(2):103-108
Rat models are often used to study liver allograft rejection. We have established a model for rat liver allograft rejection,
monitored by fine needle aspiration biopsy (FNAB), in the strain combination PVG-to-BN with a mean survival time of 37 ± 20
days. In this model, we observed acute rejection with an intense peak of lymphoid blasts and lymphocyte-dominated inflammation
in the FNAB [9.1 ± 3.0 corrected increment units (CIU)], and an eventual increase in macrophages (up to 4.2 ± 4.4 CIU), together
with fibrosis and parenchymal necrosis in the graft. Markers of immune activation, such as an increase in IL-2-receptor (from
1 % ± 2 % to 21 % ± 13 %) and class II (from 20 % ± 9 % to 43 % ± 13 %) expressing lymphoid cells and induction of ICAM-1
in the graft, were consistent with the overall cellular response. The FNAB correlated well with parallel graft histology.
In this rat model, the atraumatic monitoring makes a close follow-up possible without having to sacrifice the experimental
animals. This saves work, animals, and costs in the study of liver rejection.
Received: 2 July 1996 Accepted: 28 October 1996 相似文献
2.
Arttu Lahdenperä Anna-Maria Koivusalo Anne Vakkuri Krister Höckerstedt Helena Isoniemi 《Transplant international》2004,17(11):717-723
Abstract A blood purification system, molecular adsorbents re-circulating system (MARS), is based on the removal of both protein-bound and water-soluble substances and toxins in the liver. We treated a total of 88 patients within 2 years. Of these patients, 45 had acute liver failure (ALF), 31 had acute decompensation of chronic liver disease, eight had graft failure and four had miscellaneous conditions. Of the patients with ALF, 80% survived; in 23 patients their own liver recovered and 13 patients underwent successful transplantation. Only 23% of patients with acute-on-chronic liver failure survived. Most of them were not considered for transplantation due to their having liver failure from alcoholism and from not abstaining from drinking. MARS is a promising therapy for ALF, allowing the patient's own liver to recover or allowing enough time to find a liver graft. Best results were achieved in patients who had been intoxicated with a lethal dose of toxin. On the other hand, we did not observe much benefit in patients with severe acute-on-chronic liver failure (AcoChr) who did not undergo liver transplantation. 相似文献
3.
Krister W. Fjermestad Rene Huster Christina Thunberg Simen Stokke Claus H. Gravholt Anne‐Kristin Solbakk 《American journal of medical genetics. Part C, Seminars in medical genetics》2020,184(2):482-492
A few studies have examined neuropsychological functions, sleep, and mental health combined in Klinefelter syndrome (KS; 47,XXY). We investigated neuropsychological functions with standard tests, sleep with actigraphy, and self‐reported mental health in 30 men with KS (Mean age = 36.7 years) compared to 21 controls (Mean age = 36.8 years). Men with KS scored significantly lower on mental speed, attention span, working memory, inhibition, and set‐shifting tests, as well as overall IQ (mean effect size difference Cohen's d = 0.79). Men with KS had significantly longer night wakes, with no differences in other sleep variables (mean d = 0.34). Men with KS reported poorer mental health than controls (mean d = 1.16). Regression analyses showed neuropsychological functions explained variance in some sleep domains for men with KS but not for controls. Neuropsychological functions explained variance in some mental health domains for controls. For men with KS, however, verbal IQ was the only significant predictor of mental health. Altogether, men with KS display problems in neuropsychological functions and mental health but do not appear different from controls on most sleep parameters. Our findings indicate that relations between neuropsychological functions, sleep, and mental health differ between men with KS and controls. 相似文献
4.
5.
Nader Ghaffarpour Gsta Claesson Tomas Wester Krister K. Boman 《Acta paediatrica (Oslo, Norway : 1992)》2019,108(8):1499-1506
6.
Cheung Joseph Y.; Zhang Xue-Qian; Bokvist Krister; Tillotson Douglas L.; Miller Barbara A. 《Blood》1997,89(1):92-9100
7.
Kaukinen K Halme L Collin P Färkkilä M Mäki M Vehmanen P Partanen J Höckerstedt K 《Gastroenterology》2002,122(4):881-888
BACKGROUND & AIMS: Mild liver abnormalities are common in patients with celiac disease and usually resolve with a gluten-free diet. We investigated the occurrence of celiac disease in patients with severe liver failure. METHODS: Four patients with untreated celiac disease and severe liver disease are described. Further, the occurrence of celiac disease was studied in 185 adults with previous liver transplantation using serum immunoglobulin A endomysial and tissue transglutaminase antibodies in screening. RESULTS: Of the 4 patients with severe liver disease and celiac disease, 1 had congenital liver fibrosis, 1 had massive hepatic steatosis, and 2 had progressive hepatitis without apparent origin. Three were even remitted for consideration of liver transplantation. Hepatic dysfunction reversed in all cases when a gluten-free diet was adopted. In the transplantation group, 8 patients (4.3%) had celiac disease. Six cases were detected before the operation: 3 had primary biliary cirrhosis, 1 had autoimmune hepatitis, 1 had primary sclerosing cholangitis, and 1 had congenital liver fibrosis. Only 1 patient had maintained a long-term strict gluten-free diet. Screening found 2 cases of celiac disease, 1 with autoimmune hepatitis and 1 with secondary sclerosing cholangitis. CONCLUSIONS: The possible presence of celiac disease should be investigated in patients with severe liver disease. Dietary treatment may prevent progression to hepatic failure, even in cases in which liver transplantation is considered. 相似文献
8.
Norberg Helena Pranic Veronica Bergdahl Ellinor Lindmark Krister 《European journal of clinical pharmacology》2020,76(4):539-546
European Journal of Clinical Pharmacology - The aims of this study were to examine sex differences in a heart failure population with regards to treatment and patient characteristics and to... 相似文献
9.
Therapist‐youth agreement on alliance change predicts long‐term outcome in CBT for anxiety disorders
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10.
Johnsen SE Svensson KG Trulsson M 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,178(1):126-134
Hold-and-split tasks were performed by 20 subjects (12 females and 8 males) using the right central incisors, canines, 2nd
premolars, and 1st molars, respectively. Half a peanut was positioned on a transducer-equipped plate and the subject was instructed
to hold the plate with the peanut between two antagonistic teeth, and not using more force than necessary. After ca. 3 s the
subject was instructed to split the peanut in a natural manner. Each session consisted of a series of three in which the subject
performed the hold-and-split task five times for each tooth. Thus, in total, data were obtained from 60 trials for each subject.
The magnitude of the forces and the force rates used to split the peanut increased distally along the dental arch. However,
the duration of the split phase was similar for the various teeth examined. During anesthesia of the periodontal ligament
(four subjects), no significant changes were seen in the split phase. The forces used to hold the peanut between the teeth
also increased distally along the dental arch: 0.60 N for the incisor, 0.77 N for the canine, 1.15 N for the 2nd premolar,
and 1.74 N for the 1st molar. The difference in hold forces for the various teeth can be explained by the different sensitivity
characteristics of the periodontal afferents innervating anterior and posterior teeth. During periodontal anesthesia, the
magnitude and variability of the hold forces increased for all types of teeth, thus supporting the suggestion that periodontal
afferent information is used in the regulation of the level of forces used to hold and manipulate morsels between the teeth. 相似文献