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Gonul Buyukyilmaz Keziban Toksoy Adiguzel Esra Kılıc 《American journal of medical genetics. Part A》2023,191(6):1581-1585
Spondylo-ocular syndrome is a rare autosomal recessive disorder characterized by generalized osteoporosis, hearing loss, visual impairment due to cataract, and platyspondyly. Previous studies have revealed that the syndrome is caused by pathogenic variants in the XYLT2 gene. A patient with spondylo-ocular syndrome and two heterozygous pathogenic variant in the XYLT2 gene in compound state are described here. The patient presented with osteoporosis, platyspondyly, ocular findings, hearing loss, kyphosis, scoliosis, facial findings, intellectual disability, and undescended testicles. Previous reports of bisphosphonate treatment response were variable, whereas a long-term follow-up with bisphosphonate treatment in this case resulted in normalization of vertebral structures. Reporting such cases helps to determine the appropriate genotype–phenotype correlation in patients with XYLT2-related pathogenesis. 相似文献
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Introduction
The aim of this study was to review the factors related to the failure and extraction of unsuccessful endodontically treated teeth.Methods
A total of 1000 teeth treated with nonsurgical root canal therapy were analyzed, and the following information was recorded for each patient: reasons for failure and extraction, type of tooth, presence and type of coronal restoration, smoking status, age, gender, and level of education. One main reason was recorded for each failed tooth. The associations between reasons for failure, patient, and tooth were tested by using χ2 analysis.Results
Of the 1000 endodontically failed teeth analyzed in this study, 28.1% (n?=?281) were extracted, 66% (n?=?660) were re-treated, and 5.9% (n?=?59) were treated with apical surgery. Among the reasons for failure, restorative and endodontic reasons were seen most frequently (43.9%, n?=?439), whereas orthodontic reasons were seldom seen (0.1%, n?=?1). The most common reason for extraction was for prosthetic reasons (40.8%), and perforation/stripping was the least common (2.9%). The mandibular first molars were the most frequently extracted teeth (27.4%, n?=?77).Conclusions
The most common reason for the extraction of endodontically treated teeth was for prosthetic reasons. Among the reasons for failure, restorative and endodontic reasons were the most frequently seen, and orthodontic reasons were the most seldom. The teeth that failed most frequently were mandibular first molars, and the teeth that failed least frequently were maxillary third molars. The most common reason for the extraction of failed endodontically treated teeth was for prosthetic reasons. 相似文献4.
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Nihat Demir Erdal Peker Oğuz Tuncer Lokman Üstyol Keziban Bulan 《International Journal of Pediatric Otorhinolaryngology Extra》2013,8(2):50-52
Pierre Robin sequence (PRs) is a congenital disease characterized by micrognathia, cleft palate, glossoptosis and a wide range of other anomalies. The treatment of patients with PRs may be problematic due to the varying anomalies and high mortality rate. In this case report, a 1-day-old newborn with micrognathia, cleft lip and palate, glossoptosis, a membranous ventricular septal defect and an H-type tracheoesophageal fistula has been evaluated and discussed considering the current literature. To the best of our knowledge, the coexistence of PRs with a membranous ventricular septal defect and H-type tracheoesophageal fistula has not been previously described. 相似文献
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Zerrin Defne Dundar MD Basar Cander Mehmet Gul Keziban Ucar Karabulut Sadik Girisgin 《Academic emergency medicine》2010,17(11):1233-1238
Objectives: This experimental study aimed to assess the changes in the levels of serum ischemia‐modified albumin (IMA) and interleukin‐6 (IL‐6) by time in cases of acute mesenteric ischemia due to superior mesenteric artery occlusion. Methods: Twenty‐one New Zealand rabbits were randomly divided into three groups. Blood samples were collected at hours 0, 1, 3, and 6 from animals in a control group; a sham group following a simple laparotomy; and in an ischemia group following superior mesenteric artery ligation. All blood samples were analyzed for serum IMA and IL‐6 levels, and then the time‐dependent changes of biomarkers were investigated. Results: The serum IMA levels of the ischemia group at hours 3 and 6 were significantly higher than those of the control and sham groups (hour 3, p = 0.017; hour 6, p = 0.001). The increase in serum IL‐6 levels in the ischemia group at hours 1, 3, and 6 compared to the control and sham groups was also significant (hour 1, p = 0.002; hour 3, p = 0.003; hour 6, p = 0.003). Conclusions: IMA may be helpful as a marker in the diagnosis of acute mesenteric ischemia; however, its diagnostic value and use as a routine biochemical test should be assessed in further studies. ACADEMIC EMERGENCY MEDICINE 2010; 17:1233–1238 © 2010 by the Society for Academic Emergency Medicine 相似文献
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Mustafa Ozmen Keziban CanMustafa Ersoz 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2009,633(1):228-234
Indium-tin oxide (ITO) surfaces have become a very important material for use as a conducting substrate, recently. Immobilization of biological molecule onto the ITO is a fundamental step in the development of biosensors. In this paper, attachment of albumin was carried out using ITO as a support. Albumin was covalently immobilized onto self–assembled monolayer (SAM) of (3-isocyanatopropyl) triethoxysilane (IPTES) on ITO surface. Isocyanato-functionalized organic film was prepared by self–assembling on active ITO surface. After that, human serum albumin (HAS) which was prepared in Phosphate-Buffered Saline Solution (PBS: pH 7.4, 0.1 M), was covalently immobilized on IPTES modified ITO surface. The study here can help us understand the influence of monolayer and electrochemical behavior on ITO surface. Characterization of stepwise changes of active ITO, IPTES/ITO and albumin/IPTES/ITO surfaces were carried out using contact angle (CA) measurements, fluorescence microscopy, atomic force microscopy (AFM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV), respectively. 相似文献
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Preferential binding of ATR protein to UV-damaged DNA 总被引:12,自引:0,他引:12
Unsal-Kaçmaz K Makhov AM Griffith JD Sancar A 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(10):6673-6678
The ATR protein is a member of the phosphoinositide 3-kinase-related kinase family and plays an important role in UV-induced DNA damage checkpoint response. Its role as a signal transducer in cell cycle checkpoint is well established, but it is currently unclear whether ATR functions as a damage sensor as well. Here we have purified the ATR protein and investigated its interaction with DNA by using biochemical analysis and electron microscopy. We find that ATR is a DNA-binding protein with higher affinity to UV-damaged than undamaged DNA. In addition, damaged DNA stimulates the kinase activity of ATR to a significantly higher level than undamaged DNA. Our data suggest that ATR may function as an initial sensor in the DNA damage checkpoint response. 相似文献
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