全文获取类型
收费全文 | 289篇 |
免费 | 7篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 1篇 |
基础医学 | 35篇 |
口腔科学 | 17篇 |
临床医学 | 16篇 |
内科学 | 55篇 |
神经病学 | 7篇 |
特种医学 | 1篇 |
外科学 | 106篇 |
综合类 | 1篇 |
预防医学 | 11篇 |
药学 | 9篇 |
中国医学 | 1篇 |
肿瘤学 | 33篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 12篇 |
2019年 | 12篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 7篇 |
2014年 | 8篇 |
2013年 | 13篇 |
2012年 | 10篇 |
2011年 | 16篇 |
2010年 | 9篇 |
2009年 | 13篇 |
2008年 | 17篇 |
2007年 | 19篇 |
2006年 | 13篇 |
2005年 | 16篇 |
2004年 | 12篇 |
2003年 | 21篇 |
2002年 | 17篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1998年 | 6篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有296条查询结果,搜索用时 31 毫秒
1.
Moussa Ndong Machiko Kazami Tsukasa Suzuki Mariko Uehara Shin-ichi Katsumata Hirohumi Inoue Ken-Ichi Kobayashi Tadahiro Tadokoro Kazuharu Suzuki Yuji Yamamoto 《Nutrition Research》2009,29(9):640-647
Iron deficiency (ID) is one of the most commonly known forms of nutritional deficiencies. Low body iron is thought to induce neurologic defects but may also play a protective role against cancer development by cell growth arrest. Thus, ID may affect cellular pathways controlling cell growth and proliferation, the mechanism of which is still not fully understood. The serine/threonine protein kinase Akt and its downstream target, the mammalian Target of Rapamycin (mTOR), is known to play a crucial role in the regulation of cell growth and survival. Therefore, we hypothesized that Akt/mTOR pathway could be influenced by ID. Three-week-old male Wistar-strain rats were divided into 3 groups and the 2 groups had free access to a control diet (C group) or an iron-deficient diet (D group). The third group (PF group) were pair-fed the control diet to the mean intake of the D group. After 4 weeks, rats were killed and their brains were sampled. In separate experiments, COS-1 cells were cultured with or without the iron chelator deferoxamine. Western blots of brain samples and COS-1 lysates were used to analyze the expression and phosphorylation state of Akt, TSC2, mTOR, and S6 kinase proteins implicated in the Akt/mTOR pathway. Using 2 different ID models, we show for the first time that iron deficiency depresses Akt activity in rats and in COS-1 cells, leading to a decrease in mTOR activity. 相似文献
2.
3.
Evaluation of image-diagnosing methods of enlarged parathyroid glands in chronic renal failure 总被引:1,自引:0,他引:1
Hiroshi Takagi M.D. Yoshihiro Tominaga M.D. Kazuharu Uchida M.D. Nobuo Yamada M.D. Machio Kawai M.D. Tadayuki Kano M.D. Hiroomi Funahashi M.D. Shigeru Mizuno M.D. 《World journal of surgery》1986,10(4):605-610
Three noninvasive image-diagnosing methods, computed tomography (CT), scintigraphy with201T1C1 and99mTcOh4
–, and ultrasonography (US), were preoperatively performed on 50 patients with chronic renal failure and secondary hyperparathyroidism who underwent total parathyroidectomy and parathyroid autograft. The detection rates of the 3 methods on the 191 excised parathyroid glands were compared according to weight and location. CT detected 57.1% of all glands and 78.6% of 103 glands weighing over 500 mg. Scintigraphy detected 51.8% and 75.7%, and US detected 42.4% and 53.4%, respectively. The detection rate of upper glands was best with CT at 58.9% and 89.1%; that of lower glands was best with scintigraphy at 65.3% and 80.4%. Although the combination of the 3 methods diagnosed 69.6% and 89.5%, CT and scintigraphy, the best 2 combinations, visualized 67.5% and 88.3%.
Presented at the International Association of Endocrine Surgeons in Paris, September 1985. 相似文献
Resumen Tres métodos diagnósticos no invasivos, la tomografía computadorizada (TC), la centelleografía con201T1C1 y99mTcO4 y la ultrasonografía (US) fueron realizados preoperatoriamente en 50 pacientes con falla renal crónica e hiperparatiroidismo secundario sometidos a paratiroidectomía y autotransplante paratiroideo. Las tasas de detección de los 3 métodos fueron comparados sobre las 191 glándulas paratiroideas resecadas en relación a los pesos y a los sitios de ubicación. La TC detectó el 57.1% del total de glándulas y el 78.6% de aquellas glándulas (103) con pesos superiores a 500 mg. La centelleografía detectó 51.8% y 75.7%, y la US 42.4% y 53.4% respectivamente. La tasa de detección para las glándulas superiores fue optima con TC, con 58.9% y 89.1%; la de las glándulas inferiores fue óptima con centelleografía, con 65.3% y 80.4%. Aunque la combinación de los 3 metodos diagnosticó el 69.6% y 89.5%, la TC y la centelleografía, la mejor de las combinaciones, visualizó el 67.5% y el 88.3% respectivamente.
Résumé Trois méthodes d'imagerie non invasives, la tomodensitométrie, la scintigraphie (avec T1C1210 et TcO4 99m), et l'ultrasonographie ont été pratiquées avant l'intervention chez 50 malades qui présentaient une insuffisance rénale chronique compliquée d'hyperparathyroïdisme secondaire et qui furent traités par parathyroïdectomie totale et autogreffe parathyroïdienne. Les taux de détection de ces 3 méthodes concernant 191 glandes parathyroïdes réséquées ont été évalués en fonction du poids et du siège des lésions. La tomodensitométrie a permis de découvrir 57.1% de toutes les glandes et 78.6% des glandes dont le poids dépassait 500 mg; la scintigraphie 51.8% et 75.7%; l'ultrasonographie 42.4% et 53.4%. Le taux de détection des glandes supérieures fut plus élevé avec la tomodensitométrie: 58.9% et 89.1%; celui des glandes inférieures le fut avec la scintigraphie: 65.3% et 80.4%. Si la combinaison des 3 méthodes permet le diagnostic dans 69.6% et 89.5% des cas la tomodensitométrie associée seulement à la scintigraphie donne des résultats très voisins, les taux respectifs étant de 67.5% et de 88.3%.
Presented at the International Association of Endocrine Surgeons in Paris, September 1985. 相似文献
4.
Hiroshi Matsuzaki Ritsuko Masuyama Mariko Uehara Kahoru Nakamura Kazuharu Suzuki 《Magnesium research》2004,17(1):14-19
The effects of simultaneous increases in dietary phosphorus (P) and magnesium (Mg) concentrations while maintaining a constant P:Mg ratio on nephrocalcinosis and kidney function in female rats was investigated. Female Wistar rats were fed a control diet (3.12 g P, 0.51 g Mg per kg diet) or a diet having either 3 times the control P and Mg concentrations (3-fold diet; 9.25 g P and 1.42 g Mg per kg diet) or 5 times the control concentrations (5-fold diet; 14.97 g P and 2.37 g Mg per kg diet) for 21 d. The three experimental diets all had same P:Mg molar ratios (control diet; 4.81, 3-fold diet; 5.11, 5-fold diet; 4.96). The 3-fold diet had no significant influence on kidney calcium (Ca), Mg or P concentrations. However, kidney Ca, Mg and P concentrations were significantly higher in rats fed the 5-fold diet than in rats fed the control or 3-fold diets. No significant differences in creatinine clearance were observed among the three groups. Urinary albumin and beta 2-microglobulin excretion were higher in rats fed the 5-fold diet than in rats fed the control or 3-fold diets, while the 3-fold diet had no significant influence on the urinary albumin and beta 2-microglobulin excretion. These results suggest that absolute concentrations of dietary P and Mg are important factors with regard to the development of nephrocalcinosis and diminished kidney function. 相似文献
5.
Kazuharu Arakawa Tetsuro Hirose Toshifumi Inada Takuhiro Ito Toshie Kai Masaaki Oyama Yukihide Tomari Takao Yoda Shinichi Nakagawa 《Genes to cells : devoted to molecular & cellular mechanisms》2023,28(8):539-552
A long-standing assumption in molecular biology posits that the conservation of protein and nucleic acid sequences emphasizes the functional significance of biomolecules. These conserved sequences fold into distinct secondary and tertiary structures, enable highly specific molecular interactions, and regulate complex yet organized molecular processes within living cells. However, recent evidence suggests that biomolecules can also function through primary sequence regions that lack conservation across species or gene families. These regions typically do not form rigid structures, and their inherent flexibility is critical for their functional roles. This review examines the emerging roles and molecular mechanisms of “nondomain biomolecules,” whose functions are not easily predicted due to the absence of conserved functional domains. We propose the hypothesis that both domain- and nondomain-type molecules work together to enable flexible and efficient molecular processes within the highly crowded intracellular environment. 相似文献
6.
Takashi Kitagataya Goki Suda Kazunori Nagashima Takehiko Katsurada Koji Yamamoto Megumi Kimura Osamu Maehara Ren Yamada Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Masatsugu Ohara Machiko Umemura Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Shunsuke Ohnishi Yoshito Komatsu Hiroo Hata Satoshi Takeuchi Takashige Abe Jun Sakakibara-Konishi Takanori Teshima Akihiro Homma Naoya Sakamoto 《Journal of gastroenterology and hepatology》2020,35(10):1782-1788
7.
Satoshi Daitoku Toshinori Yuasa Hiroshi Tsunenari Shigeho Maenohara Kazuharu Mine Yuichi Tamatsu Kazuyuki Shimada Chihaya Koriyama Mitsuru Ohishi Masahisa Horiuchi 《Environmental health and preventive medicine》2015,20(3):216-223
Objectives
Although carotid artery structural variations have been detected by ultrasound, their clinical significance is not fully understood. The objective of this study was to determine whether the angle between the common carotid artery (CCA) and the internal carotid artery (ICA), designated angle α, an ultrasound-detectable carotid artery structural variation, is related to carotid artery intima-media thickness (IMT), a surrogate marker for carotid atherosclerosis.Methods
As a cross-sectional study, we measured angle α in routine carotid artery ultrasounds from 176 subjects (130 men) with atherosclerotic disease/risk factors that attended Kouseiren Hospital in Kagoshima City, Japan between August 2007 and April 2009. We evaluated the correlation between the angle α and CCA- or ICA-IMT.Results
Angle α was weakly correlated with age but significantly correlated with ICA-IMT. The correlation was stronger in subjects with an ICA-IMT ≥ 0.5 mm than in those with an ICA-IMT < 0.5 mm (Right side r = 0.475 vs. 0.246, Left side r = 0.498 vs. 0.301, respectively). Upon multivariate logistic regression analysis, angle α and serum low-density lipoprotein cholesterol were independent explanatory variables for ICA-IMT.Conclusion
Angle α is related to ICA-IMT in subjects with atherosclerotic disease or risk factors in this study.Electronic supplementary material
The online version of this article (doi:10.1007/s12199-015-0453-7) contains supplementary material, which is available to authorized users. 相似文献8.
Stenting of anomalous coronary artery is technically challenging both from the femoral and radial approaches because of difficulty in cannulating the artery by the guiding catheters with enough back-up support for delivering the stent. We report the first case in the literature of transradial coronary angioplasty and stenting to an anomalous left main coronary artery originating from the right sinus of Valsalva. Left Amplatz guidance from the radial approach provided an adequate platform to advance the stent using a dummy guidewire technique, and a self-expandable RADIUS stent was successfully deployed in a tortuous lesion of the anomalous artery. 相似文献
9.
Yamaguchi Kohei Hara Koji Nakagawa Kazuharu Namiki Chizuru Ariya Chantaramanee Yoshimi Kanako Nakane Ayako Kubota Kazumasa Furuya Junichi Tohara Haruka 《Clinical oral investigations》2020,24(11):3881-3888
Clinical Oral Investigations - This study aimed to investigate the relationship between aging and tooth loss on masseter muscle quantity and quality. This cross-sectional study was conducted among... 相似文献
10.
Masatsugu Ohara Goki Suda Megumi Kimura Osamu Maehara Tomoe Shimazaki Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Tomoe Kobayashi Minoru Uebayashi Ryo Takagi Isao Yokota Tsuyoshi Shimamura Naoya Sakamoto 《Hepatology research》2020,50(6):715-725