全文获取类型
收费全文 | 1054篇 |
免费 | 66篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 145篇 |
妇产科学 | 20篇 |
基础医学 | 74篇 |
口腔科学 | 69篇 |
临床医学 | 102篇 |
内科学 | 184篇 |
皮肤病学 | 11篇 |
神经病学 | 196篇 |
特种医学 | 140篇 |
外国民族医学 | 1篇 |
外科学 | 48篇 |
综合类 | 14篇 |
预防医学 | 28篇 |
眼科学 | 7篇 |
药学 | 71篇 |
1篇 | |
肿瘤学 | 53篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 7篇 |
2020年 | 12篇 |
2019年 | 6篇 |
2018年 | 17篇 |
2017年 | 15篇 |
2016年 | 16篇 |
2015年 | 19篇 |
2014年 | 30篇 |
2013年 | 39篇 |
2012年 | 37篇 |
2011年 | 46篇 |
2010年 | 32篇 |
2009年 | 30篇 |
2008年 | 37篇 |
2007年 | 62篇 |
2006年 | 42篇 |
2005年 | 29篇 |
2004年 | 30篇 |
2003年 | 28篇 |
2002年 | 25篇 |
2001年 | 24篇 |
2000年 | 31篇 |
1999年 | 27篇 |
1998年 | 54篇 |
1997年 | 54篇 |
1996年 | 62篇 |
1995年 | 50篇 |
1994年 | 32篇 |
1993年 | 32篇 |
1992年 | 9篇 |
1991年 | 17篇 |
1990年 | 11篇 |
1989年 | 20篇 |
1988年 | 27篇 |
1987年 | 19篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 11篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 8篇 |
1975年 | 5篇 |
1972年 | 2篇 |
1967年 | 4篇 |
排序方式: 共有1166条查询结果,搜索用时 15 毫秒
1.
2.
3.
Carel Bron Michel Wensing Jo LM Franssen Rob AB Oostendorp 《BMC musculoskeletal disorders》2007,8(1):107
Background
Shoulder disorders are a common health problem in western societies. Several treatment protocols have been developed for the clinical management of persons with shoulder pain. However available evidence does not support any protocol as being superior over others. Systematic reviews provide some evidence that certain physical therapy interventions (i.e. supervised exercises and mobilisation) are effective in particular shoulder disorders (i.e. rotator cuff disorders, mixed shoulder disorders and adhesive capsulitis), but there is an ongoing need for high quality trials of physical therapy interventions. Usually, physical therapy consists of active exercises intended to strengthen the shoulder muscles as stabilizers of the glenohumeral joint or perform mobilisations to improve restricted mobility of the glenohumeral or adjacent joints (shoulder girdle). It is generally accepted that a-traumatic shoulder problems are the result of impingement of the subacromial structures, such as the bursa or rotator cuff tendons. Myofascial trigger points (MTrPs) in shoulder muscles may also lead to a complex of symptoms that are often seen in patients diagnosed with subacromial impingement or rotator cuff tendinopathy. Little is known about the treatment of MTrPs in patients with shoulder disorders. 相似文献4.
5.
Angiographic vasospasm and release of platelet thromboxane after subarachnoid hemorrhage 总被引:3,自引:0,他引:3
S Juvela J Ohman A Servo O Heiskanen M Kaste 《Stroke; a journal of cerebral circulation》1991,22(4):451-455
We studied adenosine diphosphate-induced platelet aggregation and the associated release of thromboxane B2 in 49 patients with subarachnoid hemorrhage in relation to angiographic vasospasm. Postoperative cerebral angiography was performed less than or equal to 3 (median 1) days after surgery for an aneurysm 5-14 days after subarachnoid hemorrhage. Correspondingly, one sample from each patient was taken within 24 hours either before or after angiography. The occurrence of severe as well as diffuse, moderate, or severe angiographic vasospasm was associated with the presence of delayed cerebral ischemia (p less than 0.05). Patients with diffuse angiographic vasospasm had significantly higher (p less than 0.05) values for thromboxane B2 release than the others, even after adjustment by the clinical grades on admission and before surgery, the timing of surgery, the time from subarachnoid hemorrhage to angiography and blood sampling, and nimodipine therapy. Severe and diffuse angiographic vasospasm were also associated with poor outcome at 1 year (p less than 0.05). Our results suggest that augmented release of platelet thromboxane may be involved in the pathogenesis of vasospasm in large cerebral arteries. 相似文献
6.
H Boyd J Kaste E Hovi U M Ritanen-Mohammed H Kriinen A de la Chapelle A E Lehesjoki 《Journal of medical genetics》1994,31(3):201-205
We describe two families in whom a pericentric inversion, inv(8)(p23q11), is segregating. No examples of unbalanced karyotypes were encountered. The families originated from neighbouring parishes in western Finland. In one family a mild form of mental retardation segregated. However, this phenotype did not cosegregate with the inversion karyotype. There was no evidence of a higher than average abortion rate in the inversion carriers. Carrier matings produced 19 children with a balanced inversion and 14 children with a normal karyotype, concordant with a 1:1 segregation ratio. Of 13 karyotyped men at risk, 10 were inversion carriers. However, this difference was not statistically different from the expected 1:1 ratio. In females, the inversion carrier to normal ratio was 10:11. 相似文献
7.
8.
Depression-executive dysfunction syndrome in stroke patients. 总被引:6,自引:0,他引:6
Risto Vataja Tarja Pohjasvaara Riitta M?ntyl? Raija Ylikoski Maarit Leskel? Hely Kalska Marja Hietanen Hannu Juhani Aronen Oili Salonen Markku Kaste Antero Lepp?vuori Timo Erkinjuntti 《The American journal of geriatric psychiatry》2005,13(2):99-107
OBJECTIVE: It has been suggested that executive dysfunction could be the core defect in patients with geriatric or vascular depression, and that this depression-dysexecutive syndrome (DES) might be related to frontal-subcortical circuit dysfunction. The authors tested this hypothesis in 158 poststroke patients, of whom 21 had both depression and executive dysfunction. Methods: In this cross-sectional cohort study, a neurological, psychiatric, and neuropsychological examination was carried out 3 months after ischemic stroke, and brain infarcts, white-matter changes, and brain atrophy were recorded by MRI. RESULTS: The 21 patients with DES had significantly more brain infarcts affecting their frontal-subcortical circuit structures than the 137 patients without DES, or the 41 patients with depression but without executive dysfunction. Patients with DES also had more severe depressive symptoms and worse psychosocial functioning, and they coped less well in complex activities of daily living. CONCLUSIONS: DES is a valid concept and may define a subgroup of poststroke patients with frontal-subcortical pathology and with distinct prognosis and treatment options. 相似文献
9.
10.
Andres A; Morales JM; Praga M; Campo C; Lahera V; Garcia-Robles R; Rodicio JL; Ruilope LM 《Nephrology, dialysis, transplantation》1997,12(7):1437-1440
BACKGROUND: Cyclosporin has been shown to facilitate renal vasoconstriction
and to have an antinatriuretic effect. The existence of an interference of
cyclosporin with the vasodilating properties of endothelium mediated by
nitric oxide production could mediate these effects. On the other hand, the
infusion of the nitric oxide precursor L-arginine has been shown to induce
renal vasodilatation and to facilitate natriuresis in normal volunteers. We
have investigated the renal effects of the administration of an infusion of
L-arginine in renal transplant patients chronically treated with
cyclosporin. To facilitate the analysis of the data the effects of the
administration of a similar dose of cyclosporin on renal function during
the infusion of a vehicle were also investigated during the administration
of a vehicle of L-arginine. DESIGN: Ten male renal transplant patients,
chronically treated with cyclosporin and with a stable renal function were
studied during 2 consecutive days after the administration of the usual
morning dose of cyclosporin. The first day they received an intravenous
infusion of vehicle and the second the infusion of graded doses of
L-arginine (50, 100, 150 mg/kg/h) during 3 consecutive h. RESULTS: The
first day, after cyclosporin administration a significant fall (P <
0.01) was observed in natriuresis and kaliuresis in the absence of changes
in renal plasma flow and glomerular filtration rate. After the
administration of L-arginine significant (P < 0.01) increases of renal
plasma flow, glomerular filtration rate, and natriuresis were seen. The
increase in blood levels of cyclosporin after its administration did not
differ between days 1 and 2. CONCLUSION: These results indicate that
L-arginine facilitates renal vasodilatation and natriuresis in renal
transplant patients. Furthermore, the observed increase in sodium excretion
could indicate that L-arginine counteracts the antinatriuretic effect of
cyclosporin.
相似文献