全文获取类型
收费全文 | 2906篇 |
免费 | 99篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 72篇 |
妇产科学 | 27篇 |
基础医学 | 359篇 |
口腔科学 | 45篇 |
临床医学 | 186篇 |
内科学 | 933篇 |
皮肤病学 | 45篇 |
神经病学 | 200篇 |
特种医学 | 91篇 |
外科学 | 498篇 |
综合类 | 4篇 |
预防医学 | 105篇 |
眼科学 | 54篇 |
药学 | 147篇 |
中国医学 | 1篇 |
肿瘤学 | 249篇 |
出版年
2023年 | 13篇 |
2022年 | 50篇 |
2021年 | 69篇 |
2020年 | 32篇 |
2019年 | 60篇 |
2018年 | 70篇 |
2017年 | 44篇 |
2016年 | 54篇 |
2015年 | 65篇 |
2014年 | 82篇 |
2013年 | 116篇 |
2012年 | 175篇 |
2011年 | 185篇 |
2010年 | 104篇 |
2009年 | 98篇 |
2008年 | 160篇 |
2007年 | 200篇 |
2006年 | 196篇 |
2005年 | 188篇 |
2004年 | 131篇 |
2003年 | 165篇 |
2002年 | 172篇 |
2001年 | 43篇 |
2000年 | 32篇 |
1999年 | 43篇 |
1998年 | 53篇 |
1997年 | 34篇 |
1996年 | 34篇 |
1995年 | 29篇 |
1994年 | 33篇 |
1993年 | 21篇 |
1992年 | 26篇 |
1991年 | 24篇 |
1990年 | 14篇 |
1989年 | 20篇 |
1988年 | 14篇 |
1987年 | 17篇 |
1986年 | 17篇 |
1985年 | 10篇 |
1984年 | 15篇 |
1983年 | 18篇 |
1982年 | 23篇 |
1981年 | 10篇 |
1979年 | 4篇 |
1977年 | 8篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1966年 | 5篇 |
1964年 | 4篇 |
1962年 | 4篇 |
排序方式: 共有3026条查询结果,搜索用时 0 毫秒
1.
Mamoru Uemura MD Masahiko Higashiyama MD Jiro Okami MD Kazuyuki Oda MD Koji Takami MD Ken Kodama MD 《General thoracic and cardiovascular surgery》2006,54(2):289-292
We present a case of intrapulmonary metastasis developing 18 years after complete resection of thymoma. An 8 mm nodule in the lower lobe of the left lung was noted on chest X-ray in a 76-year-old woman who had undergone complete resection of Masaoka’s stage II thymoma 18 years earlier. Since the nodule grew to 17 mm during a 2-year follow-up, wedge resection was performed. The lesion was histologically diagnosed as an intrapulmonary metastasis from thymoma. Extremely late recurrence after complete resection of thymoma is discussed. 相似文献
2.
Yoshito Tomimaru Ken Kodama Jiro Okami Kazuyuki Oda Koji Takami Masahiko Higashiyama 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(5):193-198
Objective Postoperative pericardial effusion commonly occurs after open heart surgery. However, after general thoracotomy such as pulmonary
resection, there have been few reports of pericardial effusion. The purpose of this study is to investigate patients with
pericardial effusion following pulmonary resection.Methods: Among 2,385 patients with pulmonary resection for lung neoplasm in our institute, eight patients, whose pericardium had
never been opened during the operation, developed pericardial effusion. The clinical characteristics of the eight patients
were analyzed.Results: Pericardial effusion after pulmonary resection was divided into two subtypes: pericardial effusion in three patients with
left thoracotomy occurring within 30 days postoperatively, and pericardial effusion in the remaining five patients with right
thoracotomy occurring more than 30 days postoperatively. Pericardiotomy or pericardiocentesis was performed in three symptomatic
patients, and the remaining five asymptomatic patients were treated with diuretics. Pericardial effusion disappeared in three
of the five patients about 1–3 months after the conservative treatment, while, in the remaining patients, because pericardial
effusion had increased gradually, pericardiocentesis was performed.Conclusion: From our experience, the treatment strategy of drainage for early pericardial effusion and diuretics for late pericardial
effusion seems to be appropriate. (Jpn J Thorac Cardiovasc Surg 2006; 54:193-198) 相似文献
3.
4.
5.
Eigo Otsuji Toshiharu Yamaguchi Nozomi Yamaguchi Kunihiko Koyama Jiro Imanishi Nobuki Yamaoka Toshio Takahashi 《Surgery today》1992,22(4):351-356
In a previous study, we used a murine monoclonal antibody, A7, against human colon carcinoma as a drug-carrier to treat colorectal cancer.1 In the present study, we found that MAb A7 also reacted immunohistochemically with 73% of human pancreatic carcinoma cell lines, with the A7 antigen mainly being detected on the cell surface. However, the A7 antigen was found in only 9% of the spent media of these human pancreatic carcinoma cell lines by ELISA. On the other hand, the positive incidence of CA19-9, POA, ferritin, CEA, DU-PAN-2 and SLX in those spent media was 100%, 64%, 64%, 55%, 55% and 36%, respectively. These results suggest that the A7 antigen may only rarely be shed into the sera of pancreatic cancer patients, in which case MAb A7 could be a suitable drug-carrier in targeting chemotherapy for pancreatic cancer patients. 相似文献
6.
Masayuki Mano Akira Sugawara Yasuo Nara Kazuwa Nakao Ryoichi Horie Jiro Endo Hiroo Imura Yukio Yamori 《Clinical and experimental pharmacology & physiology》1992,19(12):795-801
1. Effects of potassium (K) supplementation (100 mEq/day) on urinary sodium (Na) excretion and on the secretion of atrial natriuretic polypeptide (ANP) during salt loading (350 mEq/day) were studied in 12 healthy salt-resistant normotensives under strictly controlled metabolic ward conditions. 2. Urinary volume and Na excretion on the first day of the high salt period (HSP) were significantly greater in the K-supplemented group (KG) than in the control group (CG). 3. There was a significant gain in bodyweight after salt loading in both groups, with a significantly greater gain in CG on the second day of HSP. Haematocrit decreased significantly during salt loading in both groups, the degree of which was significantly greater in CG. 4. Plasma norepinephrine decreased significantly during salt loading in both groups, the degree of which was significantly less in KG than in CG. A significant increase in plasma ANP was observed in CG on and after the second day of HSP, while a significant increase in plasma ANP was observed on the fifth day of HSP in KG. 5. These findings indicate that K supplementation accelerates diuresis and natriuresis, resulting in moderate suppression of volume expansion induced by salt loading and that this accelerated diuresis and natriuresis is not a result of the action of ANP. 相似文献
7.
8.
Jiro Okochi Kenji Toba Tai Takahashi Kozo Matsubayashi Masanori Nishinaga Ryutaro Takahashi Takashi Ohrui 《Geriatrics & Gerontology International》2006,6(4):223-227
Background: The aim of this study is to construct a simple screening test for the risk of falls in community-dwelling elder persons.
Methods: A total of 1378 community-dwelling people aged 65 years and older in five different communities in Japan were asked to answer a self rated questionnaire including 22 items covering physical, cognitive, emotional and social aspects of functioning and environmental factors. At a six-month follow-up, the outcome of fall occurrence and the number of falls was ascertained by social workers, health visitors or nurses.
Results: Five out of 22 items were selected using a logistic regression model. Using this five-item version, a screening test was constructed, and at the best cut-off point, the sensitivity and specificity were 68% and 70%, respectively. The validity of this scale was tested on persons with cognitive dysfunction.
Conclusion: The simplicity and the predictive validity of the screening test support the use of this test in health check ups or general outpatient facilities. 相似文献
Methods: A total of 1378 community-dwelling people aged 65 years and older in five different communities in Japan were asked to answer a self rated questionnaire including 22 items covering physical, cognitive, emotional and social aspects of functioning and environmental factors. At a six-month follow-up, the outcome of fall occurrence and the number of falls was ascertained by social workers, health visitors or nurses.
Results: Five out of 22 items were selected using a logistic regression model. Using this five-item version, a screening test was constructed, and at the best cut-off point, the sensitivity and specificity were 68% and 70%, respectively. The validity of this scale was tested on persons with cognitive dysfunction.
Conclusion: The simplicity and the predictive validity of the screening test support the use of this test in health check ups or general outpatient facilities. 相似文献
9.
Shigeki Yamagishi Kiyoshi Koizumi Tomomi Hirata Kyoji Hirai Jiro Kurita Kazuo Shimizu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(6):313-316
We report a 59-year-old woman who underwent thoracoscopic extirpation of the intrapulmonary cystic lymphangioma which was located in the subpleural space of the left upper lobe. A chest X-ray showed a solitary round nodule in the left pulmonary hilum. A computed tomography scan revealed a mass shadow at the interlobar region surrounding the interlobar pulmonary artery. A round nodule was recognized as low signal intensity on T1-weighted images by magnetic resonance imaging. There was biphasic signal intensity on T2-weighted images as well. Radiologically, we diagnosed this lesion as a benign cystic tumor in the lung. Thoracoscopic observation revealed a cystic lesion just beneath the visceral pleura of the upper lobe adjacent to the interlobular pulmonary artery. As this suggested a benign bronchogenic cyst, we performed extirpation of the cyst under thoracoscopy. After this operation, the cyst was diagnosed as an intrapulmonary cystic lymphangioma pathologically. 相似文献
10.
Shuichiro Uchiyama Kazuo Chijiiwa Masahide Hiyoshi Motoaki Nagano Jiro Ohuchida Koki Nagaike Masahiro Kai Kazuhiro Kondo 《Journal of gastrointestinal surgery》2007,11(11):1570-1572
Mucin-producing tumor in the bile duct is referred to clinically as mucin-producing bile duct tumor (MPBT). Intraductal papillary
neoplasm of the biliary tract that resembles an intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a rare category
of MPBT and is not well characterized. We, herein, report a case of MPBT of the caudate lobe of the liver that showed papillary
growth and communicated with the bile duct of the caudate lobe and protruded into the common hepatic duct. Histologically,
MPBT cells showed papillary overgrowth with abundant mucinous secretions, resembling an IPMN of the pancreas. The MPBT cells
showed the same immunostaining pattern as that of cells from IPMN of the pancreas. 相似文献