Significance of implant design on the efficacy of different peri-implantitis decontamination protocols

Clinical Oral Investigations - To assess the efficacy of three mechanical decontamination methods in four types of commercially available implants. Ninety-six implants of four commercial brands...     

Sinus floor elevation using implants coated with recombinant human bone morphogenetic protein-2: micro-computed tomographic and histomorphometric analyses

Clinical Oral Investigations - The objective of this study was to determine the validity of a graft-free sinus floor elevation (SFE) procedure with simultaneous placement of recombinant...     

The influence of perforating the autogenous block bone and the recipient bed in dogs. Part I: a radiographic analysis

Objectives: This study evaluated radiographically the integration and volume maintenance of grafted autogenous block bone under various cortical bone perforation conditions in dogs. Material and methods: Five mongrel dogs were used. Each dog received four differently prepared onlay block bone grafts: a solid block graft was fixed on either (1) a cortically perforated recipient bed (SGPR) or (2) a nonperforated recipient bed (SGNPR), a perforated block graft was fixed on either (3) a nonperforated recipient bed (PGNPR) or (4) a cortically perforated recipient bed (PGPR). The animals were sacrificed at 1 day, 4 days, 10 days, 4 weeks, and 8 weeks after surgery. Specimens were prepared and radiographic analysis was conducted by using micro‐computed tomography. The residual bone volume (RBV; mm³), cross‐sectional bone area (BA; mm²), and residual height (RH; %) of the grafted block bone were measured radiographically. Results: The interface between the recipient bed and the graft showed no signs of bone integration at 1, 4, and 10 days of healing. However, at 4 weeks of healing, bone integration was observed in all groups. The RBV, BA, and RH of the grafts gradually decreased by 4 weeks of healing. At 8 weeks, the PGPR condition exhibited a higher RBV, BA, and RH than the other conditions, whereas the SGNPR condition exhibited the lowest RBV, BA, and RH. Conclusion: Within the limitations of this study, it can be concluded that intentional cortical perforation on the recipient bed and block bone graft may influence volume maintenance of the graft. To cite this article:
Oh K‐C, Cha J‐K, Kim C‐S, Choi S‐H, Chai J‐K, Jung U‐W. The influence of perforating the autogenous block bone and the recipient bed in dogs. Part I: a radiographic analysis.
Clin. Oral Impl. Res. 22 , 2011; 1298–1302.
doi: 10.1111/j.1600‐0501.2010.02110.x     

3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects

Background: Polycarprolactone and beta tricalcium phosphate (PCL/β-TCP) are resorbable biomaterials that exhibit ideal mechanical properties as well as high affinity for osteogenic cells. Aim: Objective of this study was to evaluate healing and tissue reaction to the PCL/β-TCP barrier membrane in the rabbit calvaria model for guided bone regeneration. Materials and Methods: The PCL/β-TCP membranes were 3D printed. Three circular defects were created in calvaria of 10 rabbits. The three groups were randomly allocated for each specimen: (i) sham control; (ii) PCL/β-TCP membrane (PCL group); and (iii) PCL/β-TCP membrane with synthetic bone graft (PCL-BG group). The animals were euthanized after two (n = 5) and eight weeks (n = 5) for volumetric and histomorphometric analyses. Results: The greatest augmented volume was achieved by the PCL-BG group at both two and eight weeks (p < 0.01). There was a significant increase in new bone after eight weeks in the PCL group (p = 0.04). The PCL/β-TCP membrane remained intact after eight weeks with slight degradation, and showed good tissue integration. Conclusions: PCL/β-TCP membrane exhibited good biocompatibility, slow degradation, and ability to maintain space over eight weeks. The 3D-printed PCL/β-TCP membrane is a promising biomaterial that could be utilized for reconstruction of critical sized defects.