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Sordi Mariane B. Perrotti Vittoria Iaculli Flavia Pereira Keila C. R. Magini Ricardo S. Renvert Stefan Gattone Stefano Antonio Piattelli Adriano Bianchini Marco A. 《Clinical oral investigations》2021,25(6):3441-3451
Clinical Oral Investigations - The aim of the present study was to investigate whether peri-implant clinical parameters (modified plaque index (mPI), bleeding and/or suppuration on probing (B/SOP))... 相似文献
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Basso M Basso M Iaculli A Pompili M Riccardi L Barbaro B Rufini V Cassano A Castaldi P Barone C 《Case reports in oncology》2010,3(3):391-396
The prognosis of patients with advanced hepatocellular carcinoma (HCC) is very poor. The outcome of these patients is particularly bleak when the disease is complicated by portal vein tumor thrombosis (PVTT), since the increased portal pressure often causes serious gastrointestinal bleedings. Before the introduction of sorafenib (SOR), a tyrosine kinase inhibitor, no effective treatment was available for patients with advanced disease. SOR is now considered the standard treatment even for patients with tumor thrombosis, although the well-known interference between tyrosine kinase inhibitors and the coagulation pathway calls for caution against their use in this setting. Here, we report the case of a 74-year-old male patient with advanced HCC and PVTT treated with sunitinib (SUN), another multikinase inhibitor. During the third cycle, our patient experienced a life-threatening hematemesis with hemorrhagic shock that required intensive care treatment and SUN discontinuation. However, he completely recovered, and the PET/CT scan performed 1 year after the adverse effect demonstrated no evidence of the tumor together with portal vein recanalization. The short course of SUN causing both tumor response and gastrointestinal bleeding warrants further studies on the effectiveness of SUN in this setting as well as on the duration of treatment with multikinase inhibitors in patients with tumor thrombosis. 相似文献
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V Liso G Specchia S Capalbo V Pavone A Iacobazzi M L Iaculli R Dione N Pansini 《Acta haematologica》1992,87(1-2):54-57
Twenty adult patients with relapsed or refractory acute lymphoblastic leukemias (ALL) received a regimen employing two courses of mitoxantrone 12 mg/m2 by rapid intravenous infusion on days 1, 2 and 3 and cytosine arabinoside (ARA-C) 200 mg/m2/day by continuous infusion on days 1-7. Complete remission (CR) was achieved in 10 of 20 (50%) patients (3 refractory and 7 relapsed). Median duration of CR was 5 months (range 2-9). The treatment was associated with minimal extrahematologic toxicity, with no cardiac toxicity. Our results are nearly in line with therapeutic responses obtained with regimens employing megadose therapy (HD ARA-C). Because of acceptable toxicity, mitoxantrone plus continuous infusion of a standard dose of ARA-C could be considered for relapsed of refractory ALL patients eligible for an intensive therapeutic approach (bone marrow transplantation) after a second CR. 相似文献
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Carlo Barone Michele Basso Marco Biolato Maurizio Pompili Vittoria Rufini Luca Miele Maria Basso Anna Maria De Gaetano Paola Castaldi Alessandro Iaculli Lucia Leccisotti Laura Riccardi Antonio Grieco 《Digestive and liver disease》2013,45(8):692-698
BackgroundIn 2007, sorafenib was the first drug able to improve overall survival in patients with advanced hepatocellular carcinoma.AimIn 2005 we designed a phase II study to assess safety and efficacy of sunitinib.MethodsThis is a single arm, open-label, single-centre phase II trial. Eligibility criteria were advanced hepatocellular carcinoma; no prior chemotherapy, performance status 0–1; and Child ≤ B8. The treatment schedule was 50 mg each day orally, 4 weeks on, 2 weeks off.ResultsBetween 10/2007 and 10/2010, 34 patients were enrolled. A significant worsening of liver functional reserve after sunitinib was observed. Grade 3/4 adverse effects occurred in 80% of patients and included fatigue (47%), nausea (15%), liver failure (15%), encephalopathy (12%) and upper gastrointestinal bleeding (12%). Six patients (18%) died within 60 days of enrolment. A partial response was observed in 4 patients (12%). Median time to tumour progression was 2.8 months and median overall survival was 5.8 months.ConclusionA dose of 50 mg/d induces a high rate of severe adverse events. Toxicity remains a key concern also at the dose of 37.5 mg/d. However, sunitinib is able to induce a prolonged response in some patients. Positron Emission Tomography/Computed Tomography scans may select good responders. 相似文献
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Giuseppe Querques Anna V. Bux Domenico Martinelli Cristiana Iaculli Nicola D. Noci 《Acta ophthalmologica. Supplement》2009,87(6):623-630
Purpose: To report the functional and anatomical outcomes resulting from the use of intravitreal pegaptanib sodium (Macugen®) in patients with diabetic macular oedema (DMO). Methods: We conducted a retrospective outcome analysis, by optical coherence tomography (OCT) and best‐corrected visual acuity (BCVA), of eyes with DMO treated with intravitreal pegaptanib sodium. Moreover, we evaluated the foveal transverse photoreceptor (PR) band integrity in the OCT images at the time of the last follow‐up visit. Results: Sixty‐three eyes of 48 patients with a minimum of 6 months of follow‐up were included for analysis. Intravitreal pegaptanib was found to produce significant improvements in mean BCVA (p = 0.019) and reductions in mean central macular thickness (CMT) (p < 0.001) as soon as the 6‐week follow‐up. Most eyes (60/63) required a mean of 3.03 ± 0.9 repeated treatments, over a mean follow‐up period of 6.7 ± 1.2 months, to achieve significant improvements in mean BCVA (p < 0.001) and mean CMT (p < 0.001). In our series, the lower visual acuities tended to congregate in the group with the less‐defined PR band (p < 0.001) and the lower CMT tended to congregate in the group with the best‐defined PR band (p = 0.04), even though the higher CMT did not tend to congregate in the group with the less‐defined PR band. Conclusion: Our findings demonstrate that selective inhibition by intravitreal pegaptanib sodium of vascular endothelial growth factor (VEGF)‐165 may produce a clinically meaningful and statistically significant benefit in the treatment of DMO. 相似文献
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Sica GS Iaculli E Biancone L Di Carlo S Scaramuzzo R Fiorani C Gentileschi P Gaspari AL 《World journal of gastroenterology : WJG》2011,17(41):4602-4606
AIM:To compare long-term results of gastric cancer patients undergoing laparoscopic and open gastrec-tomy in a single unit.METHODS:From February 2000 to September 2004,all patients with adenocarcinoma of the stomach were assessed to entry in this longitudinal prospective non-randomized trial.Primary endpoint was cancer-related survival and secondary endpoints were overall survival,evaluation of surgical complications and mortality.RESULTS:Fifty-eight patients were enrolled.Forty-seven patients were followed... 相似文献