全文获取类型
收费全文 | 11025篇 |
免费 | 694篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 115篇 |
儿科学 | 277篇 |
妇产科学 | 311篇 |
基础医学 | 1499篇 |
口腔科学 | 597篇 |
临床医学 | 708篇 |
内科学 | 2724篇 |
皮肤病学 | 185篇 |
神经病学 | 1118篇 |
特种医学 | 230篇 |
外科学 | 1594篇 |
综合类 | 59篇 |
一般理论 | 3篇 |
预防医学 | 769篇 |
眼科学 | 239篇 |
药学 | 603篇 |
中国医学 | 42篇 |
肿瘤学 | 682篇 |
出版年
2023年 | 81篇 |
2022年 | 176篇 |
2021年 | 418篇 |
2020年 | 236篇 |
2019年 | 353篇 |
2018年 | 392篇 |
2017年 | 225篇 |
2016年 | 250篇 |
2015年 | 354篇 |
2014年 | 468篇 |
2013年 | 566篇 |
2012年 | 770篇 |
2011年 | 914篇 |
2010年 | 481篇 |
2009年 | 420篇 |
2008年 | 715篇 |
2007年 | 694篇 |
2006年 | 709篇 |
2005年 | 603篇 |
2004年 | 544篇 |
2003年 | 488篇 |
2002年 | 383篇 |
2001年 | 164篇 |
2000年 | 178篇 |
1999年 | 128篇 |
1998年 | 74篇 |
1997年 | 59篇 |
1996年 | 61篇 |
1995年 | 59篇 |
1994年 | 43篇 |
1993年 | 29篇 |
1992年 | 80篇 |
1991年 | 67篇 |
1990年 | 68篇 |
1989年 | 59篇 |
1988年 | 51篇 |
1987年 | 45篇 |
1986年 | 39篇 |
1985年 | 44篇 |
1984年 | 26篇 |
1983年 | 24篇 |
1982年 | 13篇 |
1980年 | 17篇 |
1979年 | 29篇 |
1977年 | 12篇 |
1976年 | 13篇 |
1974年 | 12篇 |
1970年 | 10篇 |
1968年 | 12篇 |
1967年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
8.
A R Molina H Brasch S T Tan 《Journal of plastic, reconstructive & aesthetic surgery》2006,59(12):1458-1462
One serious complication of neurofibromatosis type 1 (NF1) is the development of malignant peripheral nerve sheath tumours (MPNSTs). These malignancies often develop within pre-existing plexiform neurofibromas and their development is now thought to be associated with both tumour suppressor gene mutations and dysregulated growth factor signalling. Recent work demonstrates that the lifetime risk of malignant transformation is significantly greater than previously thought. Ionising radiation, a long-standing disease, particularly the presence of a large number of plexiform neurofibromas from an early age, are suggested risk factors. We present an NF1 patient who developed an MPNST of the cervical vagus nerve which was successfully treated with surgery. Close monitoring of patients with NF and a high level of suspicion towards rapidly enlarging and painful swellings is merited as these features may signify malignant transformation. Whether a positive history of MPNST in other affected family members predisposes the individual to a higher risk of malignant transformation is unclear. 相似文献
9.
Age-related bone loss has been associated with high levels of marrow adipogenesis. Estrogens (E2) are known to regulate the differentiation of marrow precursors into osteoblasts, however, their role in bone marrow adipogenesis
remain unknown. E2 regulate adipocyte differentiation in subcutaneous and visceral fat through interaction with other nuclear receptors. This
interaction has not been assessed in bone marrow adipocytes in vivo. In this study, we compared two groups of animals, young
and old, after either oophorectomy (OVX) or oophorectomy plus E2 (OVX + E2) replacement. We found that absence of E2 was associated with higher levels of PPARγ and lower levels of Sirt1 most significantly in the old group. In addition, old
mice responded better to E2 replacement in terms of reducing adipogenesis and PPARγ expression as well as increasing levels of Sirt1 expression. Our
findings represent a new understanding of the role of E2 in age-related bone loss, which could be mediated through the regulation of Sirt1 expression within the bone marrow. In addition,
this evidence suggests that old individuals may show a better response to E2 administration in terms of reverting the high levels of marrow fat seen in age-related bone loss. 相似文献
10.
Microanatomy and surgical approaches to the infratemporal fossa: an anaglyphic three-dimensional stereoscopic printing study. 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Skull base》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Objective: The infratemporal fossa (ITF) is a continuation of the temporal fossa between the internal surface of the zygoma and the external surface of the temporal bone and greater wing of the sphenoid bone that is sitting deep to the ramus of the mandible. The principal structure to understanding its relationships is the lateral pterygoid muscle. Other important structures are the medial pterygoid muscle, the maxillary artery, the pterygoid venous plexus, the otic ganglion, the chorda tympani nerve and the mandibular nerve. In this study, we describe the microsurgical anatomy of the ITF, as viewed by step-by-step anatomical dissection and also through the perspective of three lateral approaches and one anterior surgical approach. Methods: Eight cadaver specimens were dissected. In one side of all specimens, an anatomical dissection was done in which a wide preauricular incision from the neck on the anterior border of the sternoclidomastoid muscle at the level of the cricoid cartilage to the superior temporal line was made. The flap was displaced anteriorly and the structures of the neck were dissected followed by a zygomatic osteotomy and dissection of the ITF structures. On the other side were the surgical approaches to the ITF. The combined infratemporal and posterior fossa approach was done in two specimens, the subtemporal preauricular infratemporal fossa approach in two, the zygomatic approach in two, and the lateral transantral maxillotomy in two. The anatomical dissections were documented on the three-dimensional (3D) anaglyphic method to produce stereoscopic prints. Results: The lateral pterygoid muscle is one of the principal structures to enable understanding of the relationships into the ITF. The tendon of the temporal muscle inserts in the coronoid process at the ITF. The maxillary artery is the terminal branch of the external carotid artery that originates at the neck of the mandible and runs into the parotid gland. In our dissections the maxillary artery was lateral to the buccal, lingual, and inferior alveolar nerves. We found the second part of the maxillary artery superficial to the lateral pterygoid muscle in all specimens The anterior and posterior branches of the deep temporal artery supply the temporal muscle. In two cases we found a middle deep temporal artery. The different approaches that we used provided different views of the same anatomical landmarks and this provides not only safer surgery but also the best choice to approach the ITF according with the pathology extension. Conclusions: The ITF is a complex region on the skull base that is affected by benign and malignant tumors. The study through different routes is helpful to disclose the relationship among the anatomical structures. Although the authors have shown four approaches, there are a variety of approaches and even a combination of these can be used. This type of anatomical knowledge is essential to choosing the best approach to treat lesions in this area. 相似文献