全文获取类型
收费全文 | 1162篇 |
免费 | 74篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 32篇 |
妇产科学 | 6篇 |
基础医学 | 106篇 |
口腔科学 | 56篇 |
临床医学 | 119篇 |
内科学 | 369篇 |
皮肤病学 | 21篇 |
神经病学 | 62篇 |
特种医学 | 75篇 |
外科学 | 119篇 |
综合类 | 8篇 |
预防医学 | 53篇 |
眼科学 | 8篇 |
药学 | 77篇 |
中国医学 | 3篇 |
肿瘤学 | 136篇 |
出版年
2023年 | 13篇 |
2022年 | 19篇 |
2021年 | 34篇 |
2020年 | 24篇 |
2019年 | 32篇 |
2018年 | 35篇 |
2017年 | 25篇 |
2016年 | 34篇 |
2015年 | 38篇 |
2014年 | 35篇 |
2013年 | 39篇 |
2012年 | 71篇 |
2011年 | 80篇 |
2010年 | 33篇 |
2009年 | 43篇 |
2008年 | 59篇 |
2007年 | 71篇 |
2006年 | 49篇 |
2005年 | 41篇 |
2004年 | 50篇 |
2003年 | 36篇 |
2002年 | 32篇 |
2001年 | 27篇 |
2000年 | 22篇 |
1999年 | 30篇 |
1998年 | 30篇 |
1997年 | 22篇 |
1996年 | 17篇 |
1995年 | 15篇 |
1994年 | 16篇 |
1993年 | 18篇 |
1992年 | 12篇 |
1991年 | 15篇 |
1990年 | 5篇 |
1989年 | 11篇 |
1988年 | 18篇 |
1987年 | 12篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 6篇 |
1980年 | 7篇 |
1978年 | 10篇 |
1977年 | 6篇 |
1976年 | 11篇 |
1975年 | 4篇 |
1970年 | 4篇 |
1967年 | 4篇 |
1965年 | 4篇 |
排序方式: 共有1267条查询结果,搜索用时 15 毫秒
1.
F Vaylet A Bonnichon Y Salles E Gontier G Bonardel H Lefloch A Mairovitz M Mantzarides A Niang C Marotel H Foehrenbach 《Cancer radiothérapie》2007,11(1-2):16-22
Technological progress and numerous published studies allow to estimate the best place of the 18F-fluorodeoxyglucose positron emission tomography, a real functional metabolic imagery, in the clinical and therapeutic strategy of non small cell lung cancers. 相似文献
2.
Anna Letícia Soares Marinez de Oliveira Sousa Luci Maria Dusse Ana Paula Salles Moura Fernandes Marcelo Carvalho Lasmar Bethania Alves Novelli Geralda de Fátima Guerra Lages Maria das Gra?as Carvalho 《Blood coagulation & fibrinolysis》2007,18(5):395-399
This study aimed to investigate whether endothelial cells are damaged and to evaluate fibrinolytic system function in patients with type 2 diabetes. For this proposal, plasma levels of von Willebrand factor (an endothelial marker of injury), homocysteine (an inductor of endothelial injury), D-dimer (a marker of coagulation cascade activation) and plasminogen activator inhibitor-1 (a fibrinolysis marker) were measured in individuals with both type 2 diabetes and high blood pressure, with type 2 diabetes, with high blood pressure and in healthy control individuals. No significant differences among groups were observed for von Willebrand factor and homocysteine plasma levels. The type 2 diabetes and high blood pressure group presented a significant difference to the other groups for D-dimer and also presented high values for plasminogen activator inhibitor-1. The high blood pressure group and type 2 diabetes group presented separately higher values of plasminogen activator inhibitor-1 compared with the control group. High levels of D-dimer and plasminogen activator inhibitor-1 in patients with type 2 diabetes and high blood pressure with normoalbuminuria therefore indicate a state of hypercoagulability and hypofibrinolysis, despite no evident microvascular injury supported by normal levels of von Willebrand factor and homocysteine. 相似文献
3.
4.
5.
6.
7.
Nicolas L Monneret G Debard AL Blesius A Gutowski MC Salles G Bienvenu J 《Clinical immunology (Orlando, Fla.)》2001,98(3):358-363
The aim of our study was to compare CD3 expression on gammadelta T cells and alphabeta T cells in human patients. The antigen density of TCR and CD3 on both subsets was assessed by a quantitative method in eight patients. In parallel, we developed and validated a reliable direct tricolor staining protocol that we tested on samples from hospitalized and healthy individuals (n = 60). Our results demonstrate that human gammadelta T cells constitutively express approximately twofold more of the TCR/CD3 complex than alphabeta T cells. We suggest that this enhanced expression of the TCR/CD3 complex could contribute to the higher reactivity of gammadelta T cells compared to alphabeta T cells. These clinical laboratory results confirm the fundamental data described elsewhere. gammadelta T cells deserve further clinical investigations to understand their precise role in human immunity. 相似文献
8.
Direct evidence for the involvement of carbohydrate sequences in human sperm-zona pellucida binding 总被引:2,自引:0,他引:2
Several lines of evidence indicate that mammalian fertilization is
initiated via a binding process that is dependent upon the recognition of
oligosaccharide sequences associated with zona pellucida (ZP)
glycoproteins. Here, specific chemical and enzymatic methods were employed
to modify human ZP and to test their effects on sperm binding in the
hemizona assay system (HZA). Periodate oxidation of human ZP under very
mild conditions (10 min, 0 degrees C, 1 mM sodium m- periodate) that
attacks only terminal sialic acid resulted in a 30% loss of human sperm
binding in the HZA [hemizona index (HZI) = 70.2 +/- 10.9, n = 22; P <
0.05]. Periodate oxidation under mild conditions (1 h, 23 degrees C, 10 mM
sodium m-periodate) caused a 40% decrease in binding (HZI = 60.8 +/- 10.3;
n = 24; P< 0.01). Treatment of human ZP with neuraminidase caused a
substantial increase in sperm binding to human ZP (HZI = 297 +/- 45, n =
22; P < 0.01). These findings indicate that there are sialic acid
dependent binding sites coexisting with binding sites that are obscured by
sialic acid. To determine the periodate sensitivity of these obscured
sites, hemizona were first digested with neuraminidase and subsequently
subjected to mild periodate oxidation. The combined enzymatic and chemical
treatments caused a 79% decrease in sperm binding compared to control
hemizona (HZI = 20.7 +/- 4.4, n = 16; P < 0.001). Human sperm-ZP
interaction was also increased by digestion of human ZP with
endo-beta-galactosidase (HZI = 710 +/- 232, n = 14; P < 0.01),
indicating that potential binding sites for spermatozoa are also obscured
by lactosaminoglycan sequences. These studies support a definitive role for
the involvement of ZP-associated glycans in the binding of human
spermatozoa to oocytes.
相似文献
9.
Intensive therapy with peripheral stem cell transplantation in 16 patients with mantle cell lymphoma 总被引:2,自引:0,他引:2
N. Ketterer G. Salles D. Espinouse C. Dumontet E. M. Neidhardt-Berard I. Moullet F. Bouafia F. Berger P. Felman B. Coiffier 《Annals of oncology》1997,8(7):701-704
Background: Despite improved detection of mantle cell lymphoma (MCL),results of its treatment with conventional therapies remain disappointing andthe survival rate poor. The role of high-dose chemotherapy has recently beeninvestigated but no potential benefit has been clearly established. We reporthere our experience with MCL patients treated with intensive chemotherapy andautologous stem cell transplantation (ASCT).Patients and methods: Of the 16 MCL patients who received high-dosechemotherapy and ASCT beginning in 1989, six were treated in first-line and10 in sensitive relapse. Twelve of 16 patients received regimens whichincluded total body irradiation. All patients received peripheral blood stemcells (PBSC) with the exception of one, who underwent bone marrowtransplantation.Results: Three patients died of toxic effects of treatment. Three monthsafter transplant, seven achieved complete responses (CR) and two partialresponses (PR), two were stable and two had progressed. With a medianfollow-up after transplant of 22 months, five of the six surviving patientswere without progression, and three were in CR. The median times forevent-free survival (EFS) and overall survival (OS) were, respectively, 249and 317 days. The expected three-year EFS and OS were 24%. The mediansurvival after diagnosis was only 29 months. None of the criteria appeared tobe significantly associated with a better outcome, but first-lineintensification and a short delay after initial diagnosis may be favorable.Conclusion: In this study we were not able to confirm the hypotheticalbenefit of high-dose chemotherapy and PBSC transplantation in mantle celllymphoma, even though this approach may be promising in a subgroup of patient. 相似文献
10.
I. Moullet G. Salles N. Ketterer C. Dumontet F. Bouafia E.-M. Neidhart-Berard C. Thieblemont P. Felman B. Coiffier 《Annals of oncology》1998,9(10):1109-1115
Objectives: Retrospective evaluation of anemia frequency and its prognostic value in patients with different subtypes of non-Hodgkin's lymphoma and comparison with other clinical characteristics.Patients and methods: Anemia was defined as a hemoglobin value less than or equal to 12 g/dl for all men and women over 50 years of age, and less than or equal to 11 g/dl for women under 50 years of age. The study included 1077 adult lymphoma patients treated between 1980 and 1995 with the following histologic subtypes: 127 patients with small lymphocytic or lymphoplasmacytoid, 62 with marginal zone, 50 with mantle-cell, 208 with follicular, 104 with T-cell lymphoma, 426 with diffuse large-cell and, finally, 73 patients with other high-grade lymphomas.Results: Anemia was present in 341 patients (32%). It was an adverse prognostic factor (P <; 0.0001) for overall survival (OS) and progression-free survival (PFS) but not for relapse-free survival (RFS). When patients with and those without bone marrow involvement were considered separately, anemia remained an adverse factor. Anemia was significantly associated with shorter PFS in small lymphocytic or lymphoplasmacytoid, mantle cell, diffuse large cell and high-grade lymphomas and with shorter OS in all histologic subgroups except marginal zone lymphoma. In multivariate analysis, anemia was a significant prognostic factor for OS and PFS for the population as a whole (P = 0.0001 and P = 0.0048, respectively) and in patients with bone marrow involvement (P = 0.007 and P = 0.005, respectively) but not in patients without bone marrow involvement. Finally, the addition of anemia to the International Prognostic Index led to an improvement for OS (P = 0.0004) and PFS (P = 0.0004).Conclusions: Anemia is an important adverse prognostic factor for the outcome of lymphoma patients, particularly in some histologic subgroups and in patients with bone marrow involvement. 相似文献