全文获取类型
收费全文 | 3506篇 |
免费 | 124篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 122篇 |
儿科学 | 210篇 |
妇产科学 | 126篇 |
基础医学 | 218篇 |
口腔科学 | 151篇 |
临床医学 | 235篇 |
内科学 | 764篇 |
皮肤病学 | 100篇 |
神经病学 | 254篇 |
特种医学 | 97篇 |
外科学 | 801篇 |
综合类 | 59篇 |
预防医学 | 87篇 |
眼科学 | 96篇 |
药学 | 182篇 |
中国医学 | 71篇 |
肿瘤学 | 80篇 |
出版年
2023年 | 22篇 |
2022年 | 40篇 |
2021年 | 104篇 |
2020年 | 60篇 |
2019年 | 68篇 |
2018年 | 83篇 |
2017年 | 67篇 |
2016年 | 107篇 |
2015年 | 120篇 |
2014年 | 142篇 |
2013年 | 180篇 |
2012年 | 263篇 |
2011年 | 266篇 |
2010年 | 156篇 |
2009年 | 139篇 |
2008年 | 205篇 |
2007年 | 261篇 |
2006年 | 265篇 |
2005年 | 258篇 |
2004年 | 218篇 |
2003年 | 160篇 |
2002年 | 182篇 |
2001年 | 54篇 |
2000年 | 41篇 |
1999年 | 38篇 |
1998年 | 18篇 |
1997年 | 15篇 |
1996年 | 23篇 |
1995年 | 14篇 |
1994年 | 11篇 |
1993年 | 9篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1972年 | 4篇 |
1969年 | 1篇 |
1968年 | 3篇 |
1967年 | 2篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有3653条查询结果,搜索用时 15 毫秒
1.
2.
Yelda Karincaoglu Kadir Batcioglu Tamer Erdem Muammer Esrefoglu Metin Genc 《Journal of oral pathology & medicine》2005,34(1):7-12
BACKGROUND: Despite plenty of research, the cause of recurrent aphthous stomatitis (RAS) remains obscure. It has been proposed that, the aetiological factors such as local trauma, smoking, vitamin deficiencies and viral infections lead to aphthae formation via final common pathway based on increased oxidative stress. The aim of this investigation was to evaluate the antioxidant enzyme superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) alterations in plasma and saliva, and in addition uric acid (UA) in saliva, in patients with RAS and healthy controls. METHODS: Thirty-two patients with RAS and 30 healthy controls were included into the study. The SOD, CAT, GSHPx and UA levels were measured in plasma and saliva in study and control groups. RESULTS: In the RAS group, although the mean SOD (P<0.001) and CAT (P<0.05) levels of plasma were lower, GSHPx (P<0.001) levels were higher than control group. The salivary concentrations of the SOD (P<0.001), CAT (P<0.05) and GSHPx (P<0.001) in RAS group were entirely opposite to plasma concentrations. UA were not significant between RAS group and controls. CONCLUSION: Since we found salivary SOD and CAT levels were high whereas plasma levels were low, it has been thought that, salivary defence mechanisms via antioxidant agents may be stimulated against to the ulcerous lesion. We consider that the organism might mobilize the antioxidant potential to the sites where they were needed. At this point, decrease of SOD and CAT levels in the plasma may be related to this shift. It is also thought that GSHPx secretion in the saliva may also be increased but the increase in its turnover may be responsible for the diminished activity. 相似文献
3.
Ulver DERICI Erdal KAN Dilek ERTOY Turgay ARINSOY Ayse DURSUN Zerrin BICIK Sukru SINDEL 《Nephrology (Carlton, Vic.)》2002,7(3):155-157
SUMMARY: Renal involvement is not uncommon in rheumatoid arthritis (RA). Many RA patients have renal dysfunction either secondary to the drugs used to treat arthritis or because of the chronic inflammation. Renal pathologies have often included amyloidosis, drug-related renal disease and mesangial glomerulonephritis. However, membranoproliferative glomerulonephritis has only been rarely reported. We report a case of rheumatoid arthritis associated with membranoproliferative glomerulonephritis that rapidly progressed to end-stage renal disease. 相似文献
4.
Alp İ. Göçer M. D. Erdal Çetinalp Metin Tuna Faruk İldan Hüseyin Bağdatoğlu Sebabattin Haciyakupoğlu 《Neurosurgical review》1997,20(2):114-116
The results of percutaneous radiofrequency rhizotomy of lumbar spinal facets in 46 patients followed at least three months (mean 15 months) are reported and compared with those reported previously. Satisfactory pain relief three months after the procedure was achieved in 36.4 percent of patients without operations and in 41.7 percent of patients with operations other than fusion.No patient had previously undergone fusion.Treatment of low-back pain by using radio-frequency thermocoagulation of spinal facets is a simple, safe, and well-tolerated procedure. It can be used to relief of pain in spite of decreasing rates of success within the follow-up period. 相似文献
5.
Kadir Baykal Sükrü Yildirim Haluk Inal Erdal Kalci Selami Albayrak Hakan Cingil Yavuz Önol 《International journal of urology》1997,4(1):104-105
Metastatic carcinoma to the testis is very rare. Metastasis of prostate adenocarcinoma to testis was detected incidentally after bilateral orchiectomy for hormonal management of metastatic prostate carcinoma. The metastatic lesion was not identified in physical examination or in macroscopic dissection of the testis after surgery. Microscopy revealed an adenocarcinoma which, given the history of the patient and a positive immunohistochemical stain for PSA, was identified as metastatic prostatic adenocarcinoma. 相似文献
6.
Gokce Meral Ferda Tasar Filiz Sayin Mustafa Saysel Sedef Kir Erdem Karabulut 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(2):e25-e30
Lidocaine with epinephrine is currently the most common local anesthetic agent used for impacted third molar surgery. The purpose of the present study was to define the adverse hemodynamic effects and plasma concentrations of lidocaine and epinephrine on 17 healthy patients during the impacted teeth operations. Arterial blood pressure (systolic blood pressure, diastolic blood pressure), heart rate, peripheral oxygen saturation range, and electrocardiography were measured by an automatic noninvasive pressure device and monitor. High-performance liquid chromatography was used to measure the changes of plasma concentrations of epinephrine and lidocaine from blood samples taken 5 different times during the operation. We concluded that lidocaine-epinephrine is effective local anesthetic and had no important adverse events in healthy patients during the third molar surgery. 相似文献
7.
Alper Alkan Erdal Erdem Omer Günhan Cimen Karasu 《Journal of oral and maxillofacial surgery》2002,60(8):898-904
PURPOSE: Bone healing is impaired in diabetes mellitus, particularly due to increased collagen breakdown. Recently, tetracyclines have been used to treat experimental bone defects because they have anticollagenolytic properties, and positive effects on the healing process have been obtained. The objective of this study was to develop a computer-assisted histomorphometric technique to quantitatively determine the amount of regenerating bone within experimental bone defects in a diabetic rodent model. MATERIALS AND METHODS: This study examined the effects of systemic doxycycline administration on the healing of tibial bone defects in healthy albino rats and in experimentally induced diabetic rats. Twenty-four female albino rats were assigned to 4 groups: diabetic, diabetic plus doxycycline, control, or control plus doxycycline. The standardized bone defects were histomorphometrically examined 10 and 30 days postoperatively. Histomorphometric analysis of the amount of new bone formation was performed using the Zeiss Vision image analysis program KS 400 (Kontron Elektron GmbH, Eching, Germany). RESULTS: At 10 days of healing, the diabetic groups exhibited inferior healing compared with the control groups in terms of the amount of new bone formation within the defects. However, the effect of doxycycline administration to the diabetic and control groups was not statistically different. At 30 days of healing, there were no statistically significant differences between the amount of newly formed bone in any of the groups. CONCLUSIONS: This study found that doxycycline administration did not significantly alter the amount of new bone formation during the healing of bone defects in control and diabetic rats. 相似文献
8.
9.
Comparison of completion thyroidectomy and primary surgery for differentiated thyroid carcinoma. 总被引:2,自引:0,他引:2
AIM: The objective of this study is to analyze the complication rates after the completion thyroidectomy and compare them with primary total thyroidectomy. METHODS: The outcomes of patients with differentiated thyroid carcinoma who were operated over a period of eight years were evaluated. One hundred and forty-one patients underwent completion thyroidectomy and 92 patients had primary surgery. RESULTS: The two groups were comparable in respect of clinical variables. Residual tumor was found in 66 of 141 patients (46.8%) in completion thyroidectomy group. The rate of the two most important complications, permanent recurrent laryngeal nerve palsy and permanent hypoparathyroidism were 3.5 and 4.2%, in completion thyroidectomy group, and 3.3 and 4.3%, in primary total thyroidectomy group. The complication rates were not significantly different between groups. CONCLUSION: In conclusion, completion thyroidectomy can be done safely in a specialized center with acceptable morbidity. 相似文献
10.
Mahmut Koç Ömer Yoldaş Yusuf Alper Kılıç Erdal Göçmen Tamer Ertan Hayrettin Dizen Mesut Tez 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(5):581-585
Background and aims The aim of this study is to evaluate the predictive accuracy of different scoring systems on surgery for perforated peptic
ulcer referred to an academic department of general surgery in a tertiary reference center.
Patients and methods Seventy-five consecutive patients (Male/female ratio = 64:11; mean age, 44 years; range, 16–85) with perforated peptic ulcer
disease were investigated. Disease severity scores and mortality predictions were calculated using the collected data during
admission. Discrimination and calibration characteristics of each system, namely, the acute physiology and chronic health
evaluation II and III, the simplified acute physiology score II, and the mortality probability models (MPM) II, were determined
by using the area under receiver operating characteristics curve and the Hosmer–Lemeshow goodness-of-fit test, respectively.
Results Among the 75 patients included, there were eight (10.6%) mortalities. All systems had a reliable power of discrimination and
calibration. Among the systems tested, MPM II was the best performing as far as discrimination and calibration characteristics
were considered. The parameters of MPM II system that were related to systemic perfusion of the patient were significantly
positive in patients who died compared to those who survived.
Conclusions MPM II that predicted mortality at admission is better than the other systems in predicting mortality. Results also indicate
the importance of maintenance of systemic perfusion of the patient at the early phases of peptic ulcer perforation. 相似文献