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排序方式: 共有224条查询结果,搜索用时 15 毫秒
1.
NICOLAS SADOUL M.D. BERNARD DODINOT M.D. DANIEL BEURRIER M.D. CHRISTIAN DE. CHILLOU M.D. ETIENNE ALIOT M.D. 《Journal of interventional cardiology》1996,9(4):347-353
Dual chamber pacing is a new indication for the treatment of drug resistant hypertrophic obstructive cardiontyopathy (HOCM) in patients with normal atrioventricular (AV) conduction. In sinus rhythm, the efficacy of the treatment is mainly related to the ability to bypass the normal AV conduction system in order to obtain a complete and permanent right ventricular (RV) capture. This is achieved by programming short AV delays. On the other hand, patients with HOCM frequently have co-existing left ventricular diastolic dysfunction, and the atrial contribution to left ventricular filling is critical. The lack of improvement, rarely encountered, is probably due to incomplete RV capture andlor to the deleterious effect of short AV delay. Instrumental AV node prolongation may he indicated in this situation. This procedure should be undertaken when previous drug-induced AV prolongation has failed. In theory, AV node modulation (i.e., creating a I ± AV block) seems ideal. However, this technique remains difficult, with disappointing chronic results. Most authors hence perform "conventional" AV node ablation. Particular attention is taken in order to perform a proximal node ablation, resulting in a complete AV block with narrow QRS escape rhythm. The reported incidence of AV node prolongation ranges from 7.5%-37.5%. The efficacy of the procedure on symptoms is explained by improved left ventricular filling and/or a further reduction in the systolic gradient evoked by complete RV capture. Another indication for AV node ablation in HOCM is the occurrence of atrial fibrillation, in order to restore adequate and permanent RV capture . 相似文献
2.
ETHANOL DECREASES BASAL CYTOSOLIC-FREE CALCIUM CONCENTRATION IN CULTURED SKELETAL MUSCLE CELLS 总被引:1,自引:1,他引:0
COFAN MONTSERRAT; FERNANDEZ-SOLA JOAQUIM; NICOLAS JOSEP MARIA; POCH ESTEBAN; URBANO-MARQUEZ ALVARO 《Alcohol and alcoholism (Oxford, Oxfordshire)》1995,30(5):617-621
We analysed the effect of ethanol on basal cytosolic-free calciumconcentration ([Ca2+]1) in cultured rat myocytes. Ethanol causeda dose-dependent decrease of the resting [Ca2+]1). Removal ofethanol was followed by a transitory increase of [Ca2+]1 abovethe basal level. In cells chronically exposed to ethanol, [Ca2+]1normalized to the previous level. 相似文献
3.
JAN ERIK. NORDREHAUG M.D. Ph .D. NICOLAS A. F. CHRONOS M.B. B.S. KIM A. PRIESTLEY M.B. Ch .B. NIGEL P. BULLER M.B. B.S. JOHN FORAN M.B. B.S. RAY WAINWRIGHT B.Sc. M.D. MRCP STEIN EMIL. VOLLSET M.D. DRPH M.Ph . ULRICH SIGWART M.D. 《Journal of interventional cardiology》1996,9(5):381-388
Mechanical femoral artery compression devices have several limitations. We compared a novel disposable beltheld pneumatic compression device to manual compression alone in 213 patients randomized into two equal groups. Both were comparable for age, gender, current therapy with aspirin (ASA) and warfarin, diameter of the arterial sheath, previous procedures via the same artery, procedure duration, and blood pressure. Manual compression time was 12 ± 3 minutes. Pneumatic compression was reduced during 60 minutes. Patient discomfort was assessed as none (82% vs 88%), mild (13% vs 8%), moderate (3% vs 4%), or severe (2% vs 0%) for the manual versus pneumatic group, respectively. Bleeding and hematoma occurred in 7.5% of patients with no difference between the treatment groups. However, manual compression was significantly more effective in the higher range of systolic blood pressure, and pneumatic in the lower range, with a cut point of approximately 170 mmHg. Predictors for bleeding were systolic blood pressure and dose of ASA. Among 113 patients with systolic blood pressure < 160 mmHg and low dose (75 mg) or no ASA, only / patient (0.9%) experienced bleeding while 31% of 16 patients with both elevated systolic blood pressure and high dose ASA (150–330 mg) bled. We conclude that pneumatic femoral artery compression does not reduce bleeding and hematoma compared with manual compression. The use of low dose (75 mg) or no ASA, as well as giving special attention to patients with elevated systolic blood pressure, may reduce the risk of bleeding after cardiac catheterization . 相似文献
4.
Growing awareness of the potential benefits of advanced medicine, emerging democracies, growing middle classes and an ageing population world-wide are significant forces shaping future demand for world-class health care. Coupled with an increased awareness of the potential benefits of advanced modern medical technologies, these factors will have a dramatic impact on medical education systems. Traditional academic institutions might not represent the optimal approach to education in the 21st century. They are expensive to build and run, typically reward academic excellence not exceptional health care delivery, teach matriculating students on site, and tend to perpetuate themselves. The expertise of centres of excellence needs to be disseminated more widely, to a 'student' or client base interacting with the institution only episodically. As relevant geographic distances increase, access to such centres becomes more difficult. To attack this problem on a global basis, we must be able to teach and interact at a distance. Telemedicine is likely to form an essential part of the solution. 相似文献
5.
LAURENT MICLO EMMANUEL PERRIN ALAIN DRIOU MICHEL MELLET GUY LINDEN 《Chemical biology & drug design》1995,46(2):186-192
A method for the simultaneous determination of the ratios of the three aromatic amino-acid residues in peptides was set up in acidic conditions. Binary and ternary mixtures of these amino acids were prepared, and first- and second-derivative spectra then calculated from their 0.1 nm resolution spectra between 240 and 320 nm. Certain spectral bands were chosen to differentiate tyrosine from tryptophan on the first-derivative spectra, and phenylalanine from tyrosine and tryptophan on the second-derivative spectra. Variation of the amplitude of the chosen bands was shown to be a linear function of the ratio of the aromatic amino acids in the mixture. This technique was validated with peptides whose sequence was known. The difference between theoretical and experimentally determined ratios was lower than 10%. Since the results are obtained as ratios, neither the concentration nor the nature of the peptide has to be known. The feasibility of application using a photodiode array detector with high resolution in reversed-phase high-performance liquid chromatography is discussed. © Munksgaard 1995. 相似文献
6.
7.
CHERRIE A. MAHI-BROWN RYUZO YANAGIMACHI MARITA L. NELSON HIROKO YANAGIMACHI NICOLAS PALUMBO 《American journal of reproductive immunology (New York, N.Y. : 1989)》1988,18(3):94-103
ABSTRACT: The ovarian histopathology of bitches immunized with crude (cPZP) or partially purified (pPZP) porcine zona pellucida proteins was examined in order to determine the cause of abnormal estrous cycles. The majority of immunized bitches had ovarian cytes. Those immunized with cPZP had follicular cysts lined with a thin layer of granulosa cells, while in those immunized with pPZP, the cysts were lined by a basement membrane with a clump of luteinized cells. In two bitches immunized with cPZP, oocytes were present only in primordial follicles. Similar abnormalities were not found in a bitch immunized with human serum albumin or in 12 untreated bitches. Oocytes flushed from the oviducts of mated, immunized bitches were degenerating, which may have been a primary cause of infertility in such bitches. Ovaries studied 2–6 weeks after immunization showed no loss of gap junctional communication between oocytes and granulosa cells, nor was any inflammatory reaction seen. IgG was bound to the zona as revealed by fluoresceinated protein A staining of frozen sections of those ovaries. Abnormal estrous cycles in PZP-immunized bitches appear to result from follicular dysgenesis or cyst formation, but the etiology of these conditions is unresolved. 相似文献
8.
ELOI MARIJON M.D. Ph.D. SAMIA FAZAA M.D. KUMAR NARAYANAN M.D. BENOIT GUY‐MOYAT M.D. ABDESLAM BOUZEMAN M.D. RUI PROVIDENCIA M.D. M.S. FREDERIC TREGUER M.D. M.S. NICOLAS COMBES M.D. M.S. AGUSTIN BORTONE M.D. SERGE BOVEDA M.D. STEPHANE COMBES M.D. M.S. JEAN‐PAUL ALBENQUE M.D. 《Journal of cardiovascular electrophysiology》2014,25(2):130-137
9.
FABIO PIZZA KEIVAN K. MOGHADAM STEFANO VANDI STEFANIA DETTO FRANCESCA POLI EMMANUEL MIGNOT RAFFAELE FERRI GIUSEPPE PLAZZI 《Journal of sleep research》2013,22(1):32-40
In the diagnostic work‐up of hypersomnias of central origin, the complaint of excessive daytime sleepiness should be objectively confirmed by MSLT findings. Indeed, the features and diagnostic utility of spontaneous daytime sleep at 24 h continuous polysomnography (PSG) have never been investigated. We compared daytime PSG features to MSLT data in 98 consecutive patients presenting with excessive daytime sleepiness and with a final diagnosis of narcolepsy with cataplexy/hypocretin deficiency (n = 39), narcolepsy without cataplexy (n = 7), idiopathic hypersomnia without long sleep time (n = 19), and ‘hypersomnia’ with normal sleep latency at MSLT (n = 33). Daytime sleep time was significantly higher in narcolepsy‐cataplexy but similar in the other groups. Receiver operating characteristics (ROC) curves showed that the number of naps during daytime PSG predicted a mean sleep latency ≤8 min at MSLT with an area under the curve of 0.67 ± 0.05 (P = 0.005). The number of daytime sleep‐onset REM periods (SOREMPs) in spontaneous naps strikingly predicted the scheduled occurrence of two or more SOREMPs at MSLT, with an area under the ROC curve of 0.93 ± 0.03 (P < 10?12). One spontaneous SOREMP during daytime had a sensitivity of 96% with specificity of 74%, whereas two SOREMPs had a sensitivity of 75%, with a specificity of 95% for a pathological REM sleep propensity at MSLT. The features of spontaneous daytime sleep well correlated with MSLT findings. Notably, the occurrence of multiple spontaneous SOREMPs during daytime clearly identified patients with narcolepsy, as well as during the MSLT. 相似文献
10.
Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy 总被引:1,自引:0,他引:1
A. BELLOU I. AIMONE-GASTIN J-D. DE KORWIN J-P. BRONOWICKI A. MONERET-VAUTRIN J-P. NICOLAS M-A. BIGARD & J-L. GUÉANT 《Journal of internal medicine》1996,240(3):161-164
The first case of cobalamin deficiency with megaloblastic anaemia in a patient under long-term omeprazole therapy is presented. This patient received omeprazole at a daily dose of 40–60 mg for 4 years as treatment for a gastro-oesophagal reflux complicated by peptic oesophagitis. Seric vitamin B12 was dramatically decreased at 80 pmol L-1 . The Schilling test was normal (13%) with crystalline [57 Co] cobalamin and it was at 0% with [57 Co] cobalamin-labelled trout meat. All other assimilation tests were normal except an expiratory hydrogen breath test performed with lactulose. The haematological status was restored after intramuscular treatment with cobalamin. In conclusion, prolonged omeprazole therapy can be responsible for a cobalamin deficiency due to protein-bound cobalamin malabsorption. 相似文献