全文获取类型
收费全文 | 2520篇 |
免费 | 204篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 153篇 |
妇产科学 | 41篇 |
基础医学 | 262篇 |
口腔科学 | 56篇 |
临床医学 | 305篇 |
内科学 | 530篇 |
皮肤病学 | 35篇 |
神经病学 | 212篇 |
特种医学 | 219篇 |
外科学 | 351篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 191篇 |
眼科学 | 31篇 |
药学 | 143篇 |
中国医学 | 2篇 |
肿瘤学 | 156篇 |
出版年
2023年 | 13篇 |
2022年 | 15篇 |
2021年 | 51篇 |
2020年 | 35篇 |
2019年 | 37篇 |
2018年 | 31篇 |
2017年 | 40篇 |
2016年 | 35篇 |
2015年 | 40篇 |
2014年 | 61篇 |
2013年 | 80篇 |
2012年 | 105篇 |
2011年 | 126篇 |
2010年 | 96篇 |
2009年 | 85篇 |
2008年 | 94篇 |
2007年 | 113篇 |
2006年 | 103篇 |
2005年 | 102篇 |
2004年 | 105篇 |
2003年 | 73篇 |
2002年 | 66篇 |
2001年 | 70篇 |
2000年 | 94篇 |
1999年 | 81篇 |
1998年 | 68篇 |
1997年 | 54篇 |
1996年 | 59篇 |
1995年 | 36篇 |
1994年 | 40篇 |
1993年 | 36篇 |
1992年 | 58篇 |
1991年 | 46篇 |
1990年 | 44篇 |
1989年 | 45篇 |
1988年 | 67篇 |
1987年 | 46篇 |
1986年 | 31篇 |
1985年 | 31篇 |
1984年 | 40篇 |
1983年 | 45篇 |
1982年 | 35篇 |
1981年 | 19篇 |
1980年 | 22篇 |
1979年 | 19篇 |
1978年 | 16篇 |
1977年 | 14篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 13篇 |
排序方式: 共有2748条查询结果,搜索用时 46 毫秒
1.
Letter: faecal volatile organic metabolites,promising biomarkers in inflammatory bowel disease and Letter: faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Authors’ reply 下载免费PDF全文
I. Ahmed R. Greenwood B. Costello N. Ratcliffe C. Probert 《Alimentary pharmacology & therapeutics》2016,43(11):1241-1242
2.
Martina A. Steurer Jean Costello Rebecca J. Baer Scott P. Oltman Sky K. Feuer Tania Pacheco-Werner Elizabeth Rogers Marta M. Jankowska Jessica Block Molly McCarthy Matthew S. Pantell Christina Chambers Kelli K. Ryckman Laura L. Jelliffe-Pawlowski 《Paediatric and perinatal epidemiology》2020,34(2):130-138
3.
4.
A D Costello E K Warrington 《Journal of neurology, neurosurgery, and psychiatry》1987,50(9):1110-1116
A right-handed man with a left hemisphere lesion extending into the right hemisphere, with evidence of both a left-sided neglect dyslexia and right-sided visuospatial neglect is reported. When copying simple geometric designs he omitted to copy figures on the right-hand side of the page, when bisecting lines he tended to bisect the line to the left of the line's actual centre. He had a neglect dyslexia which was characterised by paralexic errors affecting the beginning (that is, left) of words. The occurrence of these two phenomena provides evidence of a dissociation of these forms of neglect. The findings are discussed in relation to the possible mechanisms of unilateral neglect. 相似文献
5.
Michael Rosenzweig Martha Skinner Tatiana Prokaeva Roger Théberge Catherine Costello Brian M Drachman Lawreen H Connors 《Amyloid》2007,14(1):65-71
We report the identification of a new transthyretin (TTR) gene mutation and variant protein, Glu61Gly, in a 55-year-old man with progressive cardiomyopathy, mild peripheral neuropathy and bilateral carpal tunnel syndrome. A diagnosis of TTR-associated familial amyloidosis (ATTR) was considered after an endomyocardial biopsy revealed amyloid deposits in the heart of a patient who had no family history of amyloidosis and no evidence of a plasma cell dyscrasia. Serum screening for a TTR variant by isoelectric focusing (IEF) was positive and prompted further studies to identify the genetic abnormality and to characterize the amyloidogenic protein. Direct DNA sequence analysis of all four coding regions in the TTR gene demonstrated heterozygosity in exon 3. Near equal amounts of guanine (G) and adenine (A) were observed at the second base position of codon 61. The wild-type (GAG) and mutated (GGG) sequences found in codon 61 correspond to glutamic acid (Glu) and glycine (Gly) residues, amino acids which differ in mass by -72 Da. Mass spectrometric analyses of TTR immunoprecipitated from serum showed the presence of both wild-type and variant proteins. The observed mass results for the wild-type and variant proteins were consistent with the predicted values calculated from the genetic analysis data. 相似文献
6.
J. O’Byrne S. Eustace M. M. Stephens M. N. M. R. Farahat G. Yanni R. Posten G. S. Panayi S. Sant R. Costello M. Barry J. Hassan C. Feighery B. Bresnihan A. Whelan F. Coakley A. M. de Paor R. B. Reilly E. B. Casey V. J. Tormey G. Kearns K. Gaffney P. J. Freyne M. Callaghan O. FitzGerald D. Veale E. O’Nuallain D. Reen D. Veale M. Farrell O. FitzGerald S. Rogers L. Barnes R. J. Coughlan C. McCarthy M. McDermott D. Hourihane C. O'Morain S. O'Reilly P. Hartley E. Casey L. Clancy F. Mulcahy N. Hall A. Murphy C. Breen D. Kelleher M. Abuzakouk C. O'Farrelly 《Irish journal of medical science》1992,161(6):438-442
7.
8.
Any hypothesis that tries to explain disease mechanisms in psoriasis and psoriatic arthritis (PsA) must take into account
the containment of the inflammatory process to three specific sites: the skin, synovium, and enthesis. This article reviews
the recent literature that advances our understanding of disease mechanisms at these specific sites. Additional progress will
be achieved by research that focuses on common pathogenic pathways at these sites, in particular when searching for foreign
candidates or autoantigens triggering the T-cell-mediated immune response. 相似文献
9.
Prolactin directly stimulates citrate production and mitochondrial aspartate aminotransferase of prostate epithelial cells 总被引:1,自引:0,他引:1
Prolactin, in vitro, significantly increased citrate production, mAAT (mitochondrial aspartate aminotransferase) and pmAAT (precursor form of mAAT) activity of prostate epithelial cells derived from rat lateral prostate (LP) and pig prostate cultures. In contrast, prolactin had no effect on the cytosolic isozyme, cAAT. This prolactin effect appeared to be independent of testosterone. The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin. 相似文献
10.
E J Costello A J Costello C Edelbrock B J Burns M K Dulcan D Brent S Janiszewski 《Archives of general psychiatry》1988,45(12):1107-1116
Children aged 7 to 11 years visiting their primary care pediatrician for a wide range of reasons were studied to determine the one-year prevalence of DSM-III disorders and the risk factors associated with them. Parents completing the Child Behavior Checklist about their children identified problems that placed 24.7% of 789 children in the clinical range. Detailed psychiatric interviews with 300 parents and children, using the Diagnostic Interview Schedule for Children, yielded a one-year weighted prevalence of one or more DSM-III disorders of 22.0% +/- 3.4%, combining diagnoses based on either the child or the parent interview. 相似文献