全文获取类型
收费全文 | 74篇 |
免费 | 0篇 |
专业分类
耳鼻咽喉 | 6篇 |
基础医学 | 5篇 |
口腔科学 | 3篇 |
临床医学 | 12篇 |
内科学 | 10篇 |
皮肤病学 | 3篇 |
神经病学 | 3篇 |
特种医学 | 1篇 |
外科学 | 8篇 |
综合类 | 1篇 |
预防医学 | 4篇 |
药学 | 18篇 |
出版年
2022年 | 3篇 |
2021年 | 2篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 1篇 |
2012年 | 3篇 |
2011年 | 4篇 |
2009年 | 2篇 |
2008年 | 3篇 |
2007年 | 1篇 |
2006年 | 2篇 |
2004年 | 3篇 |
2003年 | 7篇 |
2002年 | 1篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1975年 | 2篇 |
排序方式: 共有74条查询结果,搜索用时 31 毫秒
1.
P. G. Giacomini M. Alessandrini M. Evangelista B. Napolitano R. Lanciani D. Camaioni 《European Journal of Pain》2004,8(6):579-583
Sixteen subjects, affected by chronic tension-type headache (TTH) accordingly to the International Headache Society Classification (1988) criteria, in presence of tenderness in pericranial muscles,with a mean age of 37+/-11.8 years, and ten healthy volunteer subjects, age and sex matched, were submitted to postural analysis by Static Posturography (S.Ve.P. Amplaid). Aim of the study was to evaluate whether patients with TTH have disturbed postural control, as compared to normal subjects. Postural analysis considered all posturographic variables but focused on spectral frequency analysis of body sway. In both open (OE) and closed eyes (CE) condition, spectral frequency analysis showed a significantly increased body sway at low (OE= p < or = 0.01; CE= p < or = 0.01) and middle (OE= p < or = 0.01; CE= p < or = 0.01) frequencies on the antero-posterior (y) plane and at low frequencies (OE= p < or = 0.05; CE= p < or = 0.05) on the lateral (x) plane. Statistical analysis was performed using the Student's t test for unpaired data, p value 0.05 defined significant. The proprioceptive input seems to be predominant at middle and high frequencies in maintaining posture, our results seem then to suggest a proprioceptive disturbance in TTH patients. The disturbance is likely related to chronic pericranial muscle contraction and tenderness. Posturography and spectral analysis may help not only in the diagnosis of a postural disturbance but even more in the follow-up of TTH patients, during and after a medical and/or a rehabilitative treatment. 相似文献
2.
K.-N. Klotz E. Camaioni R. Volpini S. Kachler S. Vittori G. Cristalli 《Naunyn-Schmiedeberg's archives of pharmacology》1999,360(2):103-108
A number of 2-substituted 5'-N-ethylcarboxamidoadenosine (NECA) derivatives was investigated for their affinity and selectivity at human A3 adenosine receptors. The compounds were tested in radioligand competition studies and modulation of adenylyl cyclase activity on membranes from CHO cell lines stably transfected with the four human adenosine receptor subtypes. In binding studies the most potent compound, 2-(3-hydroxy-3-phenyl)propyn-1-yl-NECA (PHPNECA), exhibited a subnanomolar affinity for A3 adenosine receptors with a Ki value of 0.4 nM. As opposed to the limited A3 selectivity of PHPNECA, a 100-fold selectivity compared to both A1 and A2A receptors was found for 2-(2-phenyl)ethynyl-NECA (PENECA; Ki 6 nM). The EC50 values for activation of adenylyl cyclase via A2A adenosine receptors were in good agreement with the respective Ki values from binding experiments. In contrast, IC50 values for A1 and A3 receptor-mediated inhibition of adenylyl cyclase were shifted to higher values compared to the respective affinities determined in radioligand competition studies. Similar discrepancies between binding and functional data have been observed for the inhibitory A1 adenosine receptor in previous studies. Therefore, the same A3 selectivity of PENECA compared to A1 receptors was found in binding and adenylyl cyclase inhibition whereas the selectivity compared to A2A receptors that was detected in ligand binding was obscured in the functional assay. The series of compounds presented in this study identifies 2-substitution of the purine system as a promising target for the development of A3-selective high-affinity ligands. 相似文献
3.
The concentrations of free amino acids in plasma and cerebrospinal fluid (CSF) in 15 patients with post-traumatic cerebral oedema with hyperventilatory syndrome have been analyzed. Hypotheses are proffered to interpret the observed alterations of amino acids cerebral metabolism in this condition. 相似文献
4.
José L Boyer Arvind Mohanram Emidio Camaioni Kenneth A Jacobson T Kendall Harden 《British journal of pharmacology》1998,124(1):1-3
The antagonist activity of N6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate (N6MABP) has been examined at the phospholipase C-coupled P2Y1 receptor of turkey erythrocyte membranes. N6MABP antagonized 2MeSATP-stimulated inositol phosphate hydrolysis with a potency approximately 20 fold greater than the previously studied parent molecule, adenosine 3′,5′-bisphosphate. The P2Y1 receptor antagonism observed with N6MABP was competitive as revealed by Schild analysis (pKB=6.99±0.13). Whereas N6MABP was an antagonist at the human P2Y1 receptor, no antagonist effect of N6MABP was observed at the human P2Y2, human P2Y4 or rat P2Y6 receptors. 相似文献
5.
Clerici C Castellani D Asciutti S Pellicciari R Setchell KD O'Connell NC Sadeghpour B Camaioni E Fiorucci S Renga B Nardi E Sabatino G Clementi M Giuliano V Baldoni M Orlandi S Mazzocchi A Morelli A Morelli O 《Toxicology and applied pharmacology》2006,214(2):199-208
3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), the 7alpha-fluorine analog of hyodeoxycholic acid (HDCA), was synthesized to improve bioavailability and stability of ursodeoxycholic acid (UDCA). Acute rat biliary fistula and chronic cholestasis induced by 17alpha-ethynyl-estradiol (17EE) models were used to study and compare the effects of UPF-680 (dose range 0.6-6.0 micromol/kg min) with UDCA on bile flow, biliary bicarbonate (HCO(3)(-)), lipid output, biliary bile acid composition, hepatic enzymes and organic anion pumps. In acute infusion, UPF-680 increased bile flow in a dose-related manner, by up to 40.9%. Biliary HCO(3)(-) output was similarly increased. Changes were observed in phospholipid secretion only at the highest doses. Treatment with UDCA and UPF-680 reversed chronic cholestasis induced by 17EE; in this model, UDCA had no effect on bile flow in contrast to UPF-680, which significantly increased bile flow. With acute administration of UPF-680, the biliary bile acid pool became enriched with unconjugated and conjugated UPF-680 (71.7%) at the expense of endogenous cholic acid and muricholic isomers. With chronic administration of UPF-680 or UDCA, the main biliary bile acids were tauro conjugates, but modification of biliary bile acid pool was greater with UPF-680. UPF-680 increased the mRNA for cytochrome P450 7A1 (CYP7A1) and cytochrome P450 8B (CYP8B). Both UDCA and UPF-680 increased the mRNA for Na(+) taurocholate co-transporting polypeptide (NCTP). In conclusion, UPF-680 prevented 17EE-induced cholestasis and enriched the biliary bile acid pool with less detergent and cytotoxic bile acids. This novel fluorinated bile acid may have potential in the treatment of cholestatic liver disease. 相似文献
6.
Garocchio S Camaioni E Di Felice R De Dominicis A D'Amario M D'Arcangelo C Giannoni M 《The International journal of periodontics & restorative dentistry》2011,31(5):557-562
This report presents a new clinical protocol that facilitates the diagnostic, surgical, and prosthetic phases of immediately loaded implant rehabilitations. The proposed technique aims to simplify recording of the centric relation, which is usually done immediately after surgery, during the surgical impression phase. This shortens operative time while meeting requirements for an accurate impression and is thus simple and cost effective. The case report of a maxillary full-arch immediately loaded implant rehabilitation in a 45-year-old patient illustrates the clinical steps in the proposed procedure and confirms its repeatability. 相似文献
7.
Nora Al Jefairi Claudia Camaioni Soumaya Sridi Ghassen Cheniti Masateru Takigawa Hubert Nivet Arnaud Denis Nicolas Derval Mathilde Merle Francois Laurent Michel Montaudon Frederic Sacher Mlze Hocini Michel Haissaguerre Pierre Jais Hubert Cochet 《Journal of cardiovascular electrophysiology》2019,30(5):727-740
8.
9.
Ilaria Dato Italo Porto Claudia Camaioni Filippo Crea 《Cardiovascular Revascularization Medicine》2011,12(6):412
Background
Trans-radial access in coronary intervention has gained popularity as it grants advantages in patients with higher risk of haemorrhage, especially those with non-cardiac conditions and those treated with oral anticoagulant therapy.Case report
We report a case of percutaneous coronary intervention (PCI) of the left anterior descending (LAD) artery distal to left internal mammary artery (LIMA) anastomosis from the usually contraindicated right radial approach, in an actively bleeding patient affected by gastric cancer and chronic atrial fibrillation, and with no other available low-risk route.Conclusion
LAD trans-LIMA PCI via right radial access can be attempted in selected cases with suitable anatomy. 相似文献10.
Pellicciari R Costantino G Marinozzi M Macchiarulo A Camaioni E Natalini B 《Il Farmaco; edizione pratica》2001,56(1-2):91-94
Metabotropic glutamate receptors (mGluRs) constitute an attractive target for the development of potential neuroprotective agents. Recent advances in the elucidation of the peculiar molecular architecture of mGluRs and in the design and synthesis of subtype selective ligands are discussed. 相似文献