全文获取类型
收费全文 | 4228篇 |
免费 | 357篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 79篇 |
儿科学 | 105篇 |
妇产科学 | 48篇 |
基础医学 | 611篇 |
口腔科学 | 65篇 |
临床医学 | 500篇 |
内科学 | 717篇 |
皮肤病学 | 60篇 |
神经病学 | 512篇 |
特种医学 | 155篇 |
外国民族医学 | 1篇 |
外科学 | 706篇 |
综合类 | 27篇 |
一般理论 | 2篇 |
预防医学 | 331篇 |
眼科学 | 98篇 |
药学 | 274篇 |
中国医学 | 5篇 |
肿瘤学 | 296篇 |
出版年
2024年 | 14篇 |
2023年 | 75篇 |
2022年 | 108篇 |
2021年 | 242篇 |
2020年 | 145篇 |
2019年 | 211篇 |
2018年 | 238篇 |
2017年 | 170篇 |
2016年 | 169篇 |
2015年 | 196篇 |
2014年 | 238篇 |
2013年 | 266篇 |
2012年 | 370篇 |
2011年 | 356篇 |
2010年 | 194篇 |
2009年 | 159篇 |
2008年 | 228篇 |
2007年 | 210篇 |
2006年 | 179篇 |
2005年 | 119篇 |
2004年 | 128篇 |
2003年 | 88篇 |
2002年 | 77篇 |
2001年 | 21篇 |
2000年 | 22篇 |
1999年 | 17篇 |
1998年 | 12篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 10篇 |
1994年 | 7篇 |
1992年 | 24篇 |
1991年 | 31篇 |
1990年 | 18篇 |
1989年 | 16篇 |
1988年 | 23篇 |
1987年 | 16篇 |
1986年 | 17篇 |
1985年 | 25篇 |
1984年 | 18篇 |
1983年 | 15篇 |
1982年 | 13篇 |
1981年 | 12篇 |
1979年 | 9篇 |
1975年 | 5篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1972年 | 5篇 |
1971年 | 6篇 |
1969年 | 5篇 |
排序方式: 共有4592条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
This study looked at the prevalence of panic attacks and panic disorder in a British population. Three thousand people (aged 18-65) registered with a Leicester general practice were sent a postal questionnaire which screened for panic attacks. Where appropriate this was followed by a diagnostic interview. Preliminary results are reported for the first 1500 subjects sampled. Panic attacks are a common experience in the study population (7.5% of responders experienced them around the time of the interview). Panic disorder was diagnosed in about 3% of responders. 相似文献
7.
A A Abitbol J G Schwade A A Lewin K Sridhar A H Brandon A M Markoe R R Casiano P V Houdek C Serago D J Miller 《American journal of clinical oncology》1992,15(3):250-255
Seventeen patients were entered into a Phase I/II trial of concurrent hyperfractionated radiation therapy (7,440 cGy total dose; 120 cGy b.i.d.) combined with constant infusion of 5-fluorouracil (5-FU) (1,000 mg/m2/24 hours for 72 hours) and cisplatin (DDP) (50 mg/m2) for a total of three cycles. Thirteen patients had Stage IV disease; three, Stage III disease; and one, Stage II hypopharyngeal disease. Thirteen of 17 patients had positive cervical lymph nodes, and the mean size of the largest lymph node was 5.5 x 5.1 cm. The patients were not treated with planned adjunctive surgery except for one patient who had a radical neck dissection for massive, rapidly growing cervical adenopathy, which recurred promptly within 1 month before the initiation of protocol therapy. After the initial six patients were entered, mitomycin-C (Mito 8 mg/m2) was added during the second cycle. All the patients completed the planned course of radiotherapy with a median dose of 7,440 cGy and a mean dose of 7,248 cGy except for two patients who died--one from toxicity and the other, suicide. The predominant toxicity was mucositis, which was grade 3/4 in 11 of 15 patients, resulting in an average interruption of radiation therapy of 12 days. Weight loss was significant and was on the average 12% of baseline weight. Hematological toxicity was mild in the 5-FU/DDP group (only one grade 3 toxicity of six) and severe in the 5-FU/DDP/Mito-treated patients (five of eight patients having grade 3/4 toxicity including one leukopenic pneumonitis death). Additional toxicity included one parapharyngeal cellulitis, which responded to antibiotics. Noncompliance with the complex regimen was only seen in three patients. One patient refused b.i.d. radiation therapy, and one patient refused further chemotherapy after the first cycle. Additionally, one patient who had a severe ethanol withdrawal reaction during the first cycle of 5-FU/DDP did not receive further chemotherapy. The complete response rate of both primary site and neck by the protocol regimen alone was 71%. However, two patients, one from each group, did undergo salvage neck dissection, and the locoregional control is currently 73%, with a mean follow-up time of 18.4 months. The feasibility of combining hyperfractionated radiation therapy with aggressive concurrent chemotherapy was demonstrated. The response and local control rate justifies the added toxicity of concurrent chemotherapy and radiation therapy. 相似文献
8.
9.
Patients with xeroderma pigmentosum (XP) have defective DNA repair and a high predisposition to developing abnormalities and neoplasia in the sun-exposed areas of the skin and mucous membranes. The most common tumors reported in patients with XP are squamous cell carcinomas, basal cell carcinomas, and melanomas. Atypical fibroxanthoma (AFX) is a pleomorphic tumor that arises predominantly in the sun-damaged skin of the head and neck regions of the elderly. We describe a unique case of a 6-year-old African American boy with XP who developed an atypical fibroxanthoma and 2 squamous cell carcinomas in the conjunctiva. The clinical and histopathologic findings of AFX are discussed. 相似文献
10.
Edward L. Morgan Brandon N. Morgan Elisabeth A. Stein Elizabeth L. Vitrs Marilyn L. Thoman Sam D. Sanderson Joy A. Phillips 《Vaccine》2009
A conformationally biased, agonist of human C5a65–74 (EP67) was assessed for its adjuvant activities in vitro and in vivo. EP67 induced the release of the inflammatory (Th1) type cytokines from C5a receptor (CD88)-bearing antigen presenting cells (APC). EP67 did not induce the release of these cytokines from splenic APCs obtained from C5a receptor knockouts (CD88−/−). Serum from mice immunized with EP67–ovalbumin (OVA) contained high OVA-specific antibody (Ab) titers [IgG1, IgG2a (IGg2c), IgG2b]. Mice receiving OVA alone produced only IgG1 Abs, indicating the ability of EP67 to induce a Th1-like Ab class switch. Spleen cell cultures from wild type mice but not CD88−/− mice showed an enhanced OVA-specific proliferative response in vitro. These results indicate the ability of EP67 to drive a Th1-mediated immune response and its potential use as a unique adjuvant. 相似文献