排序方式: 共有4条查询结果,搜索用时 375 毫秒
1
1.
Struppek Julia Walther Carolin Bunte Kübra Zyriax Birgit-Christiane Wenzel Jan-Per Senftinger Juliana Nikorowitsch Julius Heydecke Guido Seedorf Udo Beikler Thomas Borof Katrin Mayer Carola Aarabi Ghazal 《Clinical oral investigations》2022,26(3):2421-2427
Clinical Oral Investigations - Positive and negative influences on oral health are attributed to coffee consumption. The aim of the current study is to evaluate the association between coffee... 相似文献
2.
3.
Benedikt M. Frey Marvin Petersen Eckhard Schlemm Carola Mayer Uta Hanning Kristin Engelke Jens Fiehler Katrin Borof Annika Jagodzinski Christian Gerloff Gtz Thomalla Bastian Cheng 《Human brain mapping》2021,42(5):1406
Cerebral small vessel disease is a common finding in the elderly and associated with various clinical sequelae. Previous studies suggest disturbances in the integration capabilities of structural brain networks as a mediating link between imaging and clinical presentations. To what extent cerebral small vessel disease might interfere with other measures of global network topology is not well understood. Connectomes were reconstructed via diffusion weighted imaging in a sample of 930 participants from a population based epidemiologic study. Linear models were fitted testing for an association of graph‐theoretical measures reflecting integration and segregation with both the Peak width of Skeletonized Mean Diffusivity (PSMD) and the load of white matter hyperintensities of presumed vascular origin (WMH). The latter were subdivided in periventricular and deep for an analysis of localisation‐dependent correlations of cerebral small vessel disease. The median WMH volume was 0.6 mL (1.4) and the median PSMD 2.18 mm2/s x 10−4 (0.5). The connectomes showed a median density of 0.880 (0.030), the median values for normalised global efficiency, normalised clustering coefficient, modularity Q and small‐world propensity were 0.780 (0.045), 1.182 (0.034), 0.593 (0.026) and 0.876 (0.040) respectively. An increasing burden of cerebral small vessel disease was significantly associated with a decreased integration and increased segregation and thus decreased small‐worldness of structural brain networks. Even in rather healthy subjects increased cerebral small vessel disease burden is accompanied by topological brain network disturbances. Segregation parameters and small‐worldness might as well contribute to the understanding of the known clinical sequelae of cerebral small vessel disease. 相似文献
4.
Carola Mayer Benedikt M Frey Eckhard Schlemm Marvin Petersen Kristin Engelke Uta Hanning Annika Jagodzinski Katrin Borof Jens Fiehler Christian Gerloff Gtz Thomalla Bastian Cheng 《Journal of cerebral blood flow and metabolism》2021,41(7):1682
We examined the relationship between white matter hyperintensities (WMH) and cortical neurodegeneration in cerebral small vessel disease (CSVD) by investigating whether cortical thickness is a remote effect of WMH through structural fiber tract connectivity in a population at increased risk of CSVD. We measured cortical thickness on T1-weighted images and segmented WMH on FLAIR images in 930 participants of a population-based cohort study at baseline. DWI-derived whole-brain probabilistic tractography was used to define WMH connectivity to cortical regions. Linear mixed-effects models were applied to analyze the relationship between cortical thickness and connectivity to WMH. Factors associated with cortical thickness (age, sex, hemisphere, region, individual differences in cortical thickness) were added as covariates. Median age was 64 [IQR 46–76] years. Visual inspection of surface maps revealed distinct connectivity patterns of cortical regions to WMH. WMH connectivity to the cortex was associated with reduced cortical thickness (p = 0.009) after controlling for covariates. This association was found for periventricular WMH (p = 0.001) only. Our results indicate an association between WMH and cortical thickness via connecting fiber tracts. The results imply a mechanism of secondary neurodegeneration in cortical regions distant, yet connected to subcortical vascular lesions, which appears to be driven by periventricular WMH. 相似文献
1