排序方式: 共有31条查询结果,搜索用时 15 毫秒
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A 59-year-old hypertensive male, 1 year after uncomplicatedmitral annuloplasty for regurgitation with MAZE procedure, witha history of chronic obstructive pulmonary disease and repeatedpulmonary 相似文献
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Statins and sepsis 总被引:1,自引:0,他引:1
Severe sepsis and septic shock is common and frequently fatal.Over the last few years, the primary treatments demonstratedto improve outcome from several major clinical trials have finallyemerged. However, translating these recent therapeutic advancesto routine clinical practice has proven controversial, and newapproaches of additional strategies are continued to be developed.Given their pleiotropic effects related to many pathophysiologicaldeterminants of sepsis, statin therapy could be the next stepin the search for adjuvant therapy. A future challenge may beto test both the efficacy and the safety by large randomizedcontrolled clinical trials ascertaining the effects of statinsadministered at the onset of sepsis and in patients with severesepsis or septic shock admitted into intensive care units. 相似文献
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Borilova Linhartova Petra Deissova Tereza Musilova Kristina Zackova Lenka Kukletova Martina Kukla Lubomir Izakovicova Holla Lydie 《Clinical oral investigations》2018,22(4):1873-1877
Clinical Oral Investigations - The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were... 相似文献
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Petra Borilova Linhartova Daniela Gachova Bretislav Lipovy 《The Journal of dermatology》2020,47(11):1236-1248
Toxic epidermal necrolysis (TEN) represents a rare drug-induced autoimmune reaction with delayed-type hypersensitivity that initiates the process of developing massive keratinocyte apoptosis, dominantly in the dermoepidermal junction. Although the etiopathophysiology has not yet been fully elucidated, the binding of Fas ligand (FasL, CD95L) to the Fas receptor (CD95) was shown to play a key role in the induction of apoptosis in this syndrome. The knowledge of the role of immunoglobulin G (IgG) in inhibition of Fas-mediated apoptosis contributed to the introduction of i.v. Ig (IVIg) in the therapy of TEN patients. Despite great enthusiasm for this therapy at the end of the 1990s, subsequent studies in various populations and meta-analyses could not unequivocally confirm the efficacy of the IVIg-based treatment concept. Today, therefore, we are faced with the dilemmas of how to adjust therapy of TEN patients most effectively, which patients could benefit from IVIg therapy and what dose of the preparation should be administrated. The ground-breaking question is: do the host genetic profiles influence the responsiveness and side-effects of IVIg therapy in TEN patients? Based on recent pharmacological, immunological and genetic findings, we suggest that the variability of IVIg therapy outcomes in TEN patients may be related to functional variants in Fas, FasL and Fc-γ receptor genes. This novel concept could lead to improved quality of care for patients with TEN, facilitating personalized therapy to reduce mortality. 相似文献
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Pavla Linhartova Ievgeniia Gazo Anna Shaliutina Martin Hulak 《Toxicology in vitro》2013,27(6):1612-1619
The sturgeon is a highly endangered fish species mostly due to over-fishing, habitat destruction, and water pollution. Duroquinone (derivative of 1,4-benzoquinone) is a xenobiotic compound widespread in the environment. The effect of duroquinone on motility, DNA integrity, and oxidative stress indices in sterlet, Acispenser ruthenus, spermatozoa was investigated. Sterlet sperm was exposed for 2 h to duroquinone at concentrations of 25, 50, 100, and 150 μM. Spermatozoa motility, velocity, and ATP content were significantly decreased with exposure to duroquinone. The level of DNA damage significantly increased at concentrations of 50 μM and above. Oxidative stress indices (lipid peroxidation and content of carbonyl proteins) and superoxide dismutase (SOD) activity increased significantly with increasing concentrations of duroquinone. Oxidative stress in sterlet spermatozoa induced by duroquinone was shown to impair spermatozoa DNA integrity, motility parameters, and the antioxidant defense system. Spermatozoa motility, content of carbonyl proteins, and SOD activity were shown to be sensitive biomarkers, exhibiting strong responses to low concentrations of the xenobiotic. Results also suggested that fish spermatozoa in vitro assays may provide a simple and efficient means of monitoring residual pollutants in the aquatic environment. 相似文献
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Katerina Machova Polakova Vojtech Kulvait Adela Benesova Jana Linhartova Hana Klamova Monika Jaruskova Caterina de Benedittis Torsten Haferlach Michele Baccarani Giovanni Martinelli Tomas Stopka Thomas Ernst Andreas Hochhaus Alexander Kohlmann Simona Soverini 《Journal of cancer research and clinical oncology》2015,141(5):887-899
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Pilny R Bouchal P Borilova S Ceskova P Zaloudik J Vyzula R Vojtesek B Valik D 《Clinical chemistry》2006,52(11):2115-2116
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Katerina Linhartova Gabriela Sterbakova Jaroslav Racek Roman Cerbak Karolina Porazikova Richard Rokyta 《Experimental & Clinical Cardiology》2009,14(3):e80-e83