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排序方式: 共有1189条查询结果,搜索用时 281 毫秒
1.
Yasser Samman Imran Masood Vijay Vardhan Killampalli Neil Howell E. Kaya Alpar Sunil K. Banerjee 《European Journal of Trauma》2005,31(2):133-137
Background and Purpose:
Management of rib fractures constitutes a major part of the trauma workload of any unit. Rib fractures result in disrupted chest wall mechanics and ventilatory insufficiency. The ability of a lung injury scoring system to predict the degree of respiratory dysfunction after rib fractures was evaluated. 相似文献2.
Bioavailability studies on guar gum-based three-layer matrix tablets of trimetazidine dihydrochloride in human volunteers. 总被引:1,自引:0,他引:1
Y S R Krishnaiah R S Karthikeyan P Bhaskar V Satyanarayana 《Journal of controlled release》2002,83(2):231-239
Guar gum-based three-layer matrix tablets of a highly water-soluble drug, trimetazidine dihydrochloride, were evaluated for their in vivo release in healthy volunteers in comparison with commercially available conventional immediate release tablets. Six healthy volunteers participated in the study and a two-way crossover design was followed. The plasma concentration of trimetazidine dihydrochloride was estimated by reverse-phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of trimetazidine dihydrochloride versus time data. The delayed T(max), decreased C(max) and K(a), unaltered bioavailability, and prolonged t(1/2) and MRT indicated a slow and prolonged release of trimetazidine dihydrochloride from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form. The guar gum three-layer matrix tablets of trimetazidine dihydrochloride may be useful in providing constant drug delivery with minimum fluctuations. 相似文献
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Edyta M. Dudzic Bangalore S. Sridhara Avijit Lahiri 《European journal of nuclear medicine and molecular imaging》1994,21(5):449-453
It has been well documented that it is not uncommon for a thallium-201 perfusion defect to develop or become more evident on delayed exercise thallium scintigraphic imaging, as compared with the initial image immediately following stress. The pathophysiology and clinical significance of the phenomenon are currently unclear. Literature on this subject is reviewed, and it is concluded that reverse redistribution of 201Tl in the post-myocardial infarction patient is indeed a fact. In this context it represents a low-risk condition and may imply successful thrombolysis, patent infarct-related coronary artery, improved wall motion at the infarct site and retained myocardial viability in that segment.
Correspondence to: A. Labiri 相似文献
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New approaches to preventing restenosis 总被引:1,自引:0,他引:1
Balram Bhargava Ganesan Karthikeyan Alexandre S Abizaid Roxana Mehran 《British medical journal》2003,327(7409):274-279
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S M Al-Saidan Y S R Krishnaiah V Satyanarayana P Bhaskar R S Karthikeyan 《European journal of pharmaceutics and biopharmaceutics》2004,58(3):697-703
The objective of the present study is to carry out pharmacokinetic evaluation of oral controlled release formulation (guar gum-based three-layer matrix tablets) containing highly soluble metoprolol tartrate as a model drug. Six healthy volunteers participated in the study, and a two-way crossover design was followed. The plasma concentration of metoprolol tartrate was estimated by reverse-phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of metoprolol tartrate versus time data. The delayed T(max) lower C(max) decreased K(a) unaltered bioavailability and prolonged t(1/2) indicated a slow and prolonged release of metoprolol tartrate from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form. The results of the study indicated that guar gum three-layer matrix tablets were able to provide oral controlled delivery of highly water-soluble drug such as metoprolol tartrate in humans. 相似文献