全文获取类型
收费全文 | 1729篇 |
免费 | 85篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 42篇 |
妇产科学 | 20篇 |
基础医学 | 202篇 |
口腔科学 | 165篇 |
临床医学 | 128篇 |
内科学 | 400篇 |
皮肤病学 | 16篇 |
神经病学 | 158篇 |
特种医学 | 44篇 |
外科学 | 258篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 137篇 |
眼科学 | 10篇 |
药学 | 146篇 |
中国医学 | 28篇 |
肿瘤学 | 40篇 |
出版年
2023年 | 16篇 |
2022年 | 21篇 |
2021年 | 66篇 |
2020年 | 45篇 |
2019年 | 45篇 |
2018年 | 53篇 |
2017年 | 29篇 |
2016年 | 60篇 |
2015年 | 62篇 |
2014年 | 76篇 |
2013年 | 91篇 |
2012年 | 142篇 |
2011年 | 151篇 |
2010年 | 99篇 |
2009年 | 59篇 |
2008年 | 95篇 |
2007年 | 103篇 |
2006年 | 66篇 |
2005年 | 63篇 |
2004年 | 67篇 |
2003年 | 51篇 |
2002年 | 32篇 |
2001年 | 29篇 |
2000年 | 35篇 |
1999年 | 25篇 |
1998年 | 14篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1992年 | 16篇 |
1991年 | 11篇 |
1990年 | 9篇 |
1989年 | 10篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 17篇 |
1983年 | 5篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 13篇 |
1979年 | 7篇 |
1978年 | 12篇 |
1976年 | 8篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1973年 | 7篇 |
1971年 | 5篇 |
1969年 | 4篇 |
1968年 | 5篇 |
排序方式: 共有1823条查询结果,搜索用时 15 毫秒
1.
John Lennon Silva Cunha Amanda Almeida Leite Thamiris de Castro Abrantes Lorena Passoni Vervloet Thayn Melo de Lima Morais Gerson de Oliveira Paiva Neto Tatiana Nayara Librio Kimura Snia Maria Soares Ferreira Ricardo Luiz Cavalcanti de Albuquerque‐Júnior Aline Corrêa Abraho Mario Jos Romaach Bruno Augusto Benevenuto de Andrade Oslei Paes de Almeida Ciro Dantas Soares 《Journal of cutaneous pathology》2021,48(1):24-33
2.
3.
4.
Genetic polymorphisms and risk of recurrent deep venous thrombosis in young people: prospective cohort study. 总被引:1,自引:0,他引:1
A Mansilha F Araújo M Severo S M Sampaio T Toledo R Albuquerque 《European journal of vascular and endovascular surgery》2005,30(5):545-549
OBJECTIVE: To determine the incidence of deep venous thrombosis (DVT) recurrence in young people, and its association with some genetic polymorphisms (FV G1691A, FII G20210A, MTHFR C677T, PAI-1 4G/5G). DESIGN: Prospective cohort study. METHODS: A database was established prospectively to follow-up a cohort of unselected patients who had had a first episode of objectively proven DVT under the age of 40 years. All patients had DNA analysis for heritable thrombophilia. We excluded patients with deficiency of antithrombin, protein C or protein S, malignant disease, antiphospholipid syndrome, or a requirement for long-term antithrombotic treatment. The end-point was objective evidence of symptomatic DVT recurrence. RESULTS: Eighty-seven patients were enrolled in the study. Mean duration of follow-up was 4.07 years. At 2 years, the cumulative recurrence rate was 19.3%. The risk of risk was not related to presence or absence of laboratory evidence of genetic polymorphisms: FV G1619A (HR 1.26 [95%CI: 0.64-2.46]; p = 0.51), FII G20210A (HR 0.81 [95%CI: 0.35-1.89]; p = 0.62), MTHFR C677T (HR 1.26 [95%CI: 0.56-2.81]; p = 0.58), PAI-1 4G/5G (0.84 [95%CI: 0.35-2.05]; p = 0.71). CONCLUSION: In this study, the risk of recurrent deep venous thrombosis in young people was not related with the presence of FV G1691A, FII G20210A, MTHFR C677T or PAI-1 4G/5G polymorphisms. 相似文献
5.
Carla Santos Araújo Roberto Roncon Albuquerque Mónica Moreira Rodrigues Benedita Sampaio Maia Adelino F Leite Moreira Manuel Pestana 《Revista portuguesa de cardiologia》2006,25(4):419-427
INTRODUCTION: The biological activity of the natriuretic peptide (NP) system is dependent on the balance between NP tissue levels and the local expression of their receptors. In the kidney, the natriuretic peptide receptor type A (NPR-A) is the principal receptor mediating NP activity and is mainly expressed in the renal medulla. An increase in circulating NP levels is well documented in chronic renal failure (CRF); however, the renal expression of NPR-A has not been evaluated in this condition. METHODS: Wistar-Han rats were submitted to right nephrectomy plus ablation of both poles of the left kidney (3/4nx; n=27) or were sham operated (Sham; n=22) and followed for up to 26 weeks post surgery. Blood pressure measurements were performed weekly. Two, 10 and 26 weeks after surgery, renal sodium and creatinine excretion were evaluated and the kidneys removed for NPR-A mRNA quantification by real-time PCR. The results of mRNA quantification are expressed in arbitrary units (AU) set as the mean value of the Sham group (Sham=1 AU), after normalization for GAPDH (p<0.05). weeks after surgery) and in elevated fractional sodium excretion (+270%, 26 weeks after surgery). Although sodium intake was similar in 3/4nx and Sham rats, blood pressure was higher in 3/4nx rats and increased progressively throughout the study. This was accompanied by a marked decrease in NPR-A mRNA levels in the renal medulla from 3/4nx animals at 2, 10 and 26 weeks post surgery. Conclusion: In 3/4nx rats, the expression of NPR-A in the renal medulla of the remnant kidney is markedly reduced from 2 weeks up to 26 weeks post surgery. It is suggested that this may contribute to the progressive increase in blood pressure, as well as to the renal fibrosis observed in 3/4nx rats. 相似文献
6.
E P A Lopes E C Gouveia A C C Albuquerque L H B C Sette L A Mello R C Moreira M R C D Coelho 《Journal of clinical virology》2006,35(3):298-302
BACKGROUND: Elevated liver enzymes are infrequent in patients with hepatitis C virus (HCV) infection undergoing chronic hemodialysis (HD), suggesting that the alanine aminotransferase (ALT) is a poor predictor of hepatocellular damage in this population. OBJECTIVE: To establish a more appropriate cut-off value of ALT to identify biochemical activity due to HCV infection in HD patients. STUDY DESIGN: A total of 217 patients, with an average age of 51.2 years, were evaluated between January and October 2002; 130 were males (60%). Serum ALT was measured by a kinetic method in five consecutive monthly blood samples, from which an average was obtained and divided by the upper limit of normal (ULN). HCV antibodies were determined using an enzyme immunoassay, the serum HCV-RNA by nested-PCR and HCV genotype by hybridization of the amplified sequence from the 5'-non-coding region. The cut-off value of ALT was obtained from a ROC curve. RESULTS: Within the 217 patients, 18 (8.3%) were anti-HCV-positive, 17 (7.8%) of whom were also HCV-RNA-positive. Genotype distribution was: 1a=47%; 1b=18%; 3a=35%. Mean ALT/ULN (0.77+/-0.57) of the 18 anti-HCV-positive cases was higher (p<0.001) than the negative group (0.38+/-0.23). The mean ALT/ULN (0.81+/-0.57) of the 17 HCV-RNA-positive cases was also higher (p<0.0001) than the negative cases (0.37+/-0.23). The cut-off value of ALT to distinguish the anti-HCV-positive from negative patients was 0.50% or 50% of the ULN (sensitivity=67%; specificity=83%). According to the HCV-RNA, the cut-off value of ALT was 0.45% or 45% of the ULN (sensitivity=71%; specificity=80%). CONCLUSION: Reducing the cut-off of ALT by half, enables a better identification of biochemical activity in patients with HCV infection on chronic HD. 相似文献
7.
Rupture of the ascending aorta is lethal in virtually all cases. In the recent literature, fewer than 9 cases of chronic, traumatic pseudoaneurysm of the ascending aorta have been documented. Reported herein is such a case, discovered incidentally and repaired successfully under cardiopulmonary bypass using a graft prosthesis. Aortogram remains the diagnostic method of choice in these patients. 相似文献
8.
9.
F. Teixeira Brandt C. D. Costa Albuquerque J. W. Barros Leal 《International urogynecology journal》1997,8(6):332-335
We report on the vaginal mucosal folds (VMF) at the urethral external meatus. Resection of the VMF reduces the dispersed micturition
and other urinary symptoms.
EDITORIAL COMMENT: The investigators describe the presence of a vaginal mucosal fold (VMF) just dorsal to the urethral meatus
and its relationship to voiding abnormalities. VMF were found on physical examination in 8.9% of the clinic population, all
of whom complained of dispersed micturition, and 79% also experienced other voiding abnormalities. The complaint of dispersed
micturition was successfully treated with excision of the VMF, and the other associated symptoms were improved. This structure
should be routinely looked for on physical examination, especially in patients with voiding symptoms. Only further investigation
of this newly described entity at other centers around the world will determine the incidence of the anatomic finding and
the prevalence of associated voiding disturbances across different populations. 相似文献
10.
Dorian Deshauer Anne Duffy Martin Alda Eva Grof Joy Albuquerque Paul Grof 《Revue canadienne de psychiatrie》2003,48(7):462-466
OBJECTIVE: A growing body of data suggests that a significantly enhanced salivary cortisol response to waking may indicate an enduring tendency to abnormal cortisol regulation. Our objective was to apply the response test to a population already known to have long-term hypothalamo-pituitary-adrenocortical (HPA) axis dysregulation. We hypothesized that the free cortisol response to waking, believed to be genetically influenced, would be elevated in a significant percentage of cases, regardless of the afternoon Dexamethasone Suppression Test (DST) value. METHOD: Using the free cortisol response to waking and the short daytime profile, we tested 18 clinically stable, lithium-responsive subjects from our long-term naturalistic follow-up of monthly DSTs. These tests include salivary testing every 15 minutes during the first hour of waking, followed by samples taken at 3:00 PM and 8:00 PM. RESULTS: While clinically stable on lithium prophylaxis, patients with bipolar disorder (BD) showed a significantly enhanced salivary cortisol response to waking, compared with control subjects (P < 0.03). Cortisol levels 30 minutes after waking significantly exceeded those in the large normative data provided in the literature (P < 0.001). CONCLUSIONS: Our observations support the hypothesis that the free cortisol response to waking can reflect relatively enduring HPA dysregulation, even when lithium-responsive BD patients are clinically well and their DSTs are normal. Because the test is easy to administer, the free cortisol response to waking may hold promise as a marker in studies of high-risk families predisposed to, or at risk for, mood disorders. 相似文献