全文获取类型
收费全文 | 2716篇 |
免费 | 179篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 62篇 |
妇产科学 | 20篇 |
基础医学 | 449篇 |
口腔科学 | 371篇 |
临床医学 | 184篇 |
内科学 | 596篇 |
皮肤病学 | 38篇 |
神经病学 | 251篇 |
特种医学 | 79篇 |
外科学 | 269篇 |
综合类 | 5篇 |
预防医学 | 150篇 |
眼科学 | 45篇 |
药学 | 196篇 |
中国医学 | 10篇 |
肿瘤学 | 163篇 |
出版年
2023年 | 22篇 |
2022年 | 41篇 |
2021年 | 74篇 |
2020年 | 46篇 |
2019年 | 56篇 |
2018年 | 79篇 |
2017年 | 60篇 |
2016年 | 76篇 |
2015年 | 81篇 |
2014年 | 130篇 |
2013年 | 141篇 |
2012年 | 224篇 |
2011年 | 245篇 |
2010年 | 140篇 |
2009年 | 117篇 |
2008年 | 220篇 |
2007年 | 180篇 |
2006年 | 193篇 |
2005年 | 148篇 |
2004年 | 154篇 |
2003年 | 155篇 |
2002年 | 97篇 |
2001年 | 10篇 |
2000年 | 13篇 |
1999年 | 19篇 |
1998年 | 15篇 |
1997年 | 29篇 |
1996年 | 19篇 |
1995年 | 24篇 |
1994年 | 13篇 |
1993年 | 2篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1971年 | 2篇 |
1966年 | 2篇 |
1932年 | 2篇 |
1914年 | 2篇 |
排序方式: 共有2906条查询结果,搜索用时 10 毫秒
1.
2.
André Ricardo Adriano Tiago Silveira Lima Maxime Battistella Martine Bagot 《Anais brasileiros de dermatologia》2015,90(6):892-895
Granulomatous slack skin is an indolent T-cell lymphoma, considered to be a
variant of mycosis fungoides. Clinically it is characterized by areas of
redundant skin, wrinkled, inelastic, with variable erythema and
infiltration besides a poikilodermic surface. A differential diagnosis
unknown to most dermatologists is the giant cell tumor of soft tissue,
which is an extremely rare low-grade sarcoma. The authors report a patient
who had undergone extensive surgery because of a primary diagnosis of giant
cell tumor of soft tissue, but which proved to be granulomatous slack skin
after a second interventional procedure with confirmatory
histopathology. 相似文献
3.
Adriano Chiò Elena Herrero Hernandez Gabriele Mora Consuelo Valentini Gianluigi Discalzi Enrico Pira 《Amyotrophic lateral sclerosis and other motor neuron disorders》2004,5(3):188-191
A 34-years-old floor-layer developed optic neuropathy and motor neuron disease after being accidentally exposed to a solvent mixture containing methanol and other substances. Optic neuropathy is a complication of methanol poisoning, but the onset of a motor neuron disorder resembling amyotrophic lateral sclerosis after the exposure to these substances has not been previously described. The temporal onset of the clinical symptoms, biological plausibility, young age of the patient and absence of neurological disorders in the family history raises suspicion of a possible causative relationship. 相似文献
4.
Antonella d’Arminio Monforte Paola Cinque Luca Vago Aleandro Rocca Antonella Castagna Cristina Gervasoni Maria Rosa Terreni Roberto Novati Andrea Gori Adriano Lazzarin Mauro Moroni 《Journal of neurology》1996,244(1):35-39
Twenty patients with AIDS who had intracranial lesions underwent both brain biopsy and cerebro-spinal fluid (CSF) examination
to compare histological diagnosis with the polymerase chain reaction (CSF-PCR) for the identification of infectious agents.
CSF-PCR was performed for herpes simplex virus, varicella zoster virus, cytomegalovirus (CMV), JC virus (JCV), Epstein-Barr
virus (EBV), Toxoplasma gondii and Mycobacterium tuberculosis. A definitive diagnosis was obtained by brain biopsy in 14 patients (2 with astrocytoma, 12 with brain infection). CSF-PCR
was positive for EBV DNA in 3 of 3 cases of primary cerebral lymphoma, positive for JCV DNA in 6 of 7 biopsy-proven (and one
autopsy-proven) cases of progressive multifocal leukoencephalopathy (PML). CSF-PCR was positive for CMV DNA in one biopsy-proven
and one autopsy-proven case of CMV encephalitis (the former also had PML) and positive for M. tuberculosis DNA in one case of tuberculous encephalitis. None of the five toxoplasmic encephalitis cases (one definite, four presumptive)
were T. gondii DNA positive. There was close correlation between histology and CSF-PCR for CMV encephalitis, PML and PCL. Antitoxoplasma
therapy affected the sensitivity of both histological and CSF-PCR methods.
Received: 8 November 1995 Received in revised form: 9 July 1996 Accepted: 19 July 1996 相似文献
5.
Summary
The virological findings obtained during an outbreak of Bornholm disease which took place in the summer 1957 in Cermignano, in the province of Teramo, Italy, are described.
During this study it was possible to isolate 15 strains of a Goxsackie B2 type virus. 3 strains were isolated simultaneously from rectal and pharyn geal swabs, while 9 strains were isolated from pharyngeal swabs only. 相似文献
6.
7.
Ultrastructural Localization of Alpha-Naphthyl Acid Esterase in Human TM Lymphocytes 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Antonio Zicca Annaldo Leprini Angela Cadoni Adriano T. Franzi Manlis Ferrarini Carlo E. Grossi 《The American journal of pathology》1981,105(1):40-46
The localization of alpha-naphthyl acid esterase (ANAE) activity in T lymphocytes with receptors for IgM (TM cells) have been studied at the electron microscope. The electron-opaque product of the cytochemical reaction was detected around, but never inside, single (or groups of) vesicles, which suggested a possible membrane localization of the enzyme activity. These same vesicles were found to contain acid phosphatase by both light- and electron-microscopic examination and were bound by unit membranes; this data indicates that they likely represent primary lysosomes. The presence of such lysosomes in a restricted paranuclear area is a distinctive feature of TM cells. 相似文献
8.
9.
Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches 总被引:7,自引:0,他引:7
Spahn TW Weiner HL Rennert PD Lügering N Fontana A Domschke W Kucharzik T 《European journal of immunology》2002,32(4):1109-1113
We have previously demonstrated the loss of oral tolerance (OT) in lymphotoxinalpha-/- (LTalpha-/-) and TNFalpha / lymphotoxinalpha deficient (TNFalpha / LTalpha-/-) mice which have defective Peyer's patches (PP) and lymph node (LN) development. We have now studied OT in BALB / c mice with differential defects of the gut-associated lymphoid tissue (GALT) caused by inhibition of LTbetaR signaling during fetal development. Treatment of pregnant mice with LTbetaR-IgG (LTbetaRIgG) and TNFR I55-IgG (TNFR55IgG) abrogates the formation of PP (LTbetaRIgG) or of PP and mesenteric LN (MLN) (LTbetaRIgG / TNFRIgG) without genetically deleting the respective cytokine pathways. OT was readily induced in mice without PP but retaining MLN (PP null / LN +). In contrast, OTcould not be induced in mice lacking both MLN and PP (PP null / MLN null) as shown by the inability of these mice to suppress IFN-gamma secretion or DTH reactions. We next assessed OT in 129 x B6 LTalpha-/- mice with and without MLN. Timed treatment of pregnant LTalpha-/- mice with an agonist anti-LTbetaR mAb induces formation of MLN but not of PP in LTalpha-/- mice. LN + LTalpha-/- mice developed OT while LN LTalpha-/- mice were resistant to OT induction. Taken collectively, the data show that in the presence of MLN PP are not required for OT induction and that the presence of MLN is sufficient for OT induction in the LTalpha-/- model. 相似文献
10.
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis 总被引:6,自引:0,他引:6
Wickenden JA Clarke MC Rossi AG Rahman I Faux SP Donaldson K MacNee W 《American journal of respiratory cell and molecular biology》2003,29(5):562-570
Emphysema is characterized by enlargement of the distal airspaces in the lungs due to destruction of alveolar walls. Alveolar endothelial and epithelial cell apoptosis induced by cigarette smoke is thought to be a possible mechanism for this cell loss. In contrast, our studies show that cigarette smoke condensate (CSC) induces necrosis in alveolar epithelial cells and human umbilical vein endothelial cells. Furthermore, study of the cell death pathway in a model system using Jurkat cells revealed that in addition to inducing necrosis, CSC inhibited apoptosis induced by staurosporine or Fas ligation, with both effects prevented by the antioxidants glutathione and dithiothreitol. Time course experiments revealed that CSC inhibited an early step in the caspase cascade, whereby caspase-3 was not activated. Moreover, cell-free reconstitution of the apoptosome in cytoplasmic extracts from CSC-treated cells, by addition of cytochrome-c and dATP, did not result in activation of caspases-3 or -9. Thus, smoke treatment may alter the levels of pro- and antiapoptogenic factors downstream of the mitochondria to inhibit active apoptosome formation. Therefore, unlike previous studies, cell death in response to cigarette smoke by necrosis and not apoptosis may be responsible for the loss of alveolar walls and inflammation observed in emphysema. 相似文献