非酒精性脂肪性肝病患者血清瘦素和脂联素与胰岛素抵抗的关系

Objective To investigate the serum leptin and adiponectin levels in nonalcoholic fatty liver disease (NAFLD) patients, and their relationship with insulin resistance. Methods A total of 120 cases were enrolled and divided into two groups: NAFLD group (n = 60) and normal control group (n = 60). The serum levels of leptin and adiponectin were measured by EL1SA. The body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol (Tchol), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), fasting blood glucose (FBG) and HOMA-IR (homeostasis model assessment insulin resistance) were detected and analyzed. Results Compared with control group, the serum leptin level in NAFLD group was Significantly higher [(12.37 ± 1.99) μg/Lvs (5.20 ± 1.03)μg/L,P<0.01], while the serum adiponectin level was significantly lower [(12.69 ± 2.83) mg/L vs (22.83 ± 4.61) mg/L, P < 0.01]. HOMA-IR was also much higher in NAFLD group than that in control group[(4.86 ± 0.63) vs (1.91 ± 0.41), P < 0.01]. Logistic regression analysis showed that leptin was positively correlated with WHR ( P = 8.175, P < 0.01), HOMA-IR ( P = 0.974, P < 0.01 ), FBG ( β = 0.564, P < 0.01). In contrast, adiponectin inversely associated with HOMA-IR ( β = -0.495, P < 0.01 ) and BMI ( β = -0.314, P < 0.01) respectively. Conclusions The increased serum leptin level and decreased serum adiponectin level in NAFLD patients independently associated with HOMA-IR.     

非酒精性脂肪性肝病患者血清瘦素和脂联素与胰岛素抵抗的关系

Objective To investigate the serum leptin and adiponectin levels in nonalcoholic fatty liver disease (NAFLD) patients, and their relationship with insulin resistance. Methods A total of 120 cases were enrolled and divided into two groups: NAFLD group (n = 60) and normal control group (n = 60). The serum levels of leptin and adiponectin were measured by EL1SA. The body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol (Tchol), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), fasting blood glucose (FBG) and HOMA-IR (homeostasis model assessment insulin resistance) were detected and analyzed. Results Compared with control group, the serum leptin level in NAFLD group was Significantly higher [(12.37 ± 1.99) μg/Lvs (5.20 ± 1.03)μg/L,P<0.01], while the serum adiponectin level was significantly lower [(12.69 ± 2.83) mg/L vs (22.83 ± 4.61) mg/L, P < 0.01]. HOMA-IR was also much higher in NAFLD group than that in control group[(4.86 ± 0.63) vs (1.91 ± 0.41), P < 0.01]. Logistic regression analysis showed that leptin was positively correlated with WHR ( P = 8.175, P < 0.01), HOMA-IR ( P = 0.974, P < 0.01 ), FBG ( β = 0.564, P < 0.01). In contrast, adiponectin inversely associated with HOMA-IR ( β = -0.495, P < 0.01 ) and BMI ( β = -0.314, P < 0.01) respectively. Conclusions The increased serum leptin level and decreased serum adiponectin level in NAFLD patients independently associated with HOMA-IR.     

自体颗粒脂肪注射移植充填面部软组织凹陷

目的探讨自体颗粒脂肪注射移植充填矫治面部凹陷的临床应用。方法标记面部凹陷部位,估计需要填充的脂肪量,取臀部或大腿部为供区。在肿胀麻醉下,用20 m l注射器吸脂,吸管采用3.0 mm的钝头吸管,负压应控制在20 m l注射器内3～5 m l左右真空。抽取脂肪颗粒,无菌状况下将所获脂肪颗粒洗去血迹、破碎脂肪细胞和脂滴,反复漂洗,至漂洗液色清透明;静置、分层后取中层饱满的脂肪颗粒注射在面部凹陷部位。结果采用自体脂肪颗粒移植充填矫正面部凹陷26例,其中6例患者经过了3次注射充填;12例患者经过了2次注射充填;8例患者经过了1次注射充填,均获良好效果。结论利用自体脂肪移植充填矫治面部凹陷,创伤小、并发症低、手术效果明显,相对现有其他治疗方法,是一种较为理想的治疗方法。     

178例肝硬化的并发症分析

肝硬化是大多数慢性肝病发展的终末期阶段，患者往往因其并发症的出现病情迅速恶化，甚至死亡。掌握各种常见并发症的特点，寻求有效的防治措施，对改善肝硬化患者的预后有着重要的意义。现对我院2007年1月～2007年10月住院的178例肝硬化患者的并发症进行分析：     

非酒精性脂肪性肝病患者血清瘦素和脂联素与胰岛素抵抗的关系

目的 探讨非酒精性脂肪性肝病(NAFLD)患者血清瘦素、脂联素的变化及其与胰岛素抵抗的关系. 方法 选取NAFLD患者60例,同期门诊体检健康者60名为对照组,ELJSA法测定血清瘦素、脂联素水平,并检测体质量指数、腰臀比、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、空腹血糖、ALT、AST、γ-谷氨酰转肽酶(GGT),稳态模型评估的胰岛素抵抗指数(HOMA-IR).采用SPSS10.0软件包进行统计学分析,计量资料差异性比较用方差分析和t检验,多因素相关性用Spearman分析和Logistic回归分析. 结果 血清瘦素、脂联素水平NAFLD组分别为(12.37±1.99)μg/L和(12.69±2.83)mg/L,对照组分别为(5.20±1.03)μg/L和(22.83±4.61)mg/L,t值分别为24.661和14.516,P值均<0.01;HOMA-IR,NAFLD组为4.86±0.63,对照组为1.91±0.41,t值为30.451,P<0.01.Logistic多因素回归分析显示瘦素与腰臀围之比、HOMA-IR、空腹血糖呈独立正相关,β值分别为8.175、0.974和0.564,P值均<0.01;脂联素与HOMA-IR、体质量指数呈独立负相关,β值分别为-0.495和-0.314,P值均<0.01.结论 NAFLD患者血清瘦素、脂联素的变化与胰岛素抵抗有关.     

聚乳酸-聚羟乙酸／磷酸三钙薄膜预防屈肌腱粘连的实验

目的：探讨在屈肌腱损伤修复后应用和不应用聚乳酸-聚羟乙酸／磷酸三钙薄膜包裹两种情况下，术后不同时期屈肌腱的粘连情况和聚乳酸-聚羟乙酸／磷酸三钙薄膜在肌腱愈合过程中的作用。方法：实验于2004-03／10在东南大学修复重建外科研究所实验室进行。选取健康成熟的三黄鸡40只，以右足第2，3趾深屈肌腱横断后修复作为肌腱粘连的动物模型，取右足第2趾为实验趾、第3趾为对照趾。聚乳酸-聚羟乙酸／磷酸三钙薄膜包裹，术后3，4，8周分别取材。通过生物力学、大体观察、组织学及扫描电镜检查，观测肌腱愈合情况、与周围组织的粘连情况、屈趾功能及假鞘结构。结果：进入结果分析的实验鸡39只。①实验趾肌腱的屈趾功能明显优于对照趾[术后3周：（10．53&;#177;1．07），（7．78&;#177;0．37）mm，术后4周：（14．96&;#177;1.51），（9．37&;#177;1．35）mm，术后8周：（19．93&;#177;0．81），（11．47&;#177;0．15）mm，P〈0．05]。②大体观察实验趾在各时间段肌腱与腱周组织的粘连均较对照趾轻，肌腱为内源性愈合，并形成具有正常滑膜A、B型细胞的假鞘结构，与肌腱间有间隙。结论：聚乳酸-聚羟乙酸／磷酸三钙薄膜通过刺激周围组织形成假鞘，阻止来自腱周的粘连，且不影响肌腱正常愈合，是较理想的预防肌腱粘连材料。     

嗜酒与乙型肝炎病毒感染的临床特征

我国是HBV感染的高流行区，根据2002年全国HBV感染者血清流行病学调查，3岁以上人群HBsAg的阳性率为9．09％。慢性HBV感染者中，肝硬化失代偿的年发生率约3％，5年累计发生率约16％，其中6％-15％可发展为肝细胞癌，长期持续的高病毒负荷增加了肝硬化、肝癌患者死亡的危险性。随着我国经济的发展和人民生活水平的提高，饮食习惯的改变和社会交往的增多，酒精的消耗量和嗜酒者也逐年增加，     

肝硬化病因及临床特点分析178例

目的:探讨东北地区肝硬化患者病因及临床特点.方法:选择我院2007-01/2007-10住院确诊的肝硬化患者178例,回顾性分析患者的临床资料和实验室检查结果.结果:178例患者中单纯乙型肝炎病毒感染61例(34.3%),单纯丙型肝炎病毒感染11例(6.2%),乙型与丙型肝炎病毒重叠感染3例(1.7%),单纯饮酒所致肝硬化39例(21.9%),酒精合并肝炎病毒共同损伤所致肝硬化27例(15.2%),其他为原发性胆汁性肝硬化8例(4.5%),不明原因肝硬化29例(16.3%).肝炎病毒感染和酒精中毒所致肝硬化相比,除蜘蛛痣(x2=4.503,P=0.034)外,其他症状和体征的发生率无显著性差异.肝硬化并发症为上消化道出血(42.0%)、原发性肝癌(28.7%)、继发感染(16.1%)和肝性脑病(11.2%).结论:东北地区的肝硬化病因仍然以乙型肝炎病毒感染为主.单纯病毒感染所致肝硬化的临床表现以门脉压力增高为主,酒精中毒则以肝功能损伤为主,肝炎病毒重叠感染及嗜酒与病毒感染并存容易导致肝癌的发生.     

RICU高龄患者机械通气初期睡眠障碍原因分析

目的:了解呼吸重症监护病房(RICU)高龄患者机械通气初期睡眠情况及影响因素。方法:采用匹兹堡睡眠质量指数对2010.1～2011.6收治RICU的50例高龄患者机械通气初期睡眠情况进行评估,用自编调查表研究睡眠质量的影响因素。结果:50例患者PSQl评分7.86±4.28分,其中有睡眠问题的占64%;引起的原因有年龄、环境陌生、医源性干扰、生理和心理不适。结论:RICU高龄患者机械通气初期睡眠差,其影响因素多,护士可根据实际情况采取个体化护理对策,改善患者睡眠质量,促进患者康复。     

RICU高龄患者机械通气初期睡眠障碍原因分析

目的:了解呼吸重症监护病房(RICU)高龄患者机械通气初期睡眠情况及影响因素。方法:采用匹兹堡睡眠质量指数对2010.1-2011.6收治RICU的50例高龄患者机械通气初期睡眠情况进行评估,用自编调查表研究睡眠质量的影响因素。结果:50例患者PSQl评分(7.86±4.28)分,其中有睡眠问题的占64%;引起的原因有年龄、环境陌生、医源性干扰、生理和心理不适。结论:RICU高龄患者机械通气初期睡眠差,其影响因素多,护士可根据实际情况采取个体化护理对策,改善患者睡眠质量,促进患者康复。