全文获取类型
收费全文 | 277062篇 |
免费 | 18024篇 |
国内免费 | 602篇 |
专业分类
耳鼻咽喉 | 3290篇 |
儿科学 | 8567篇 |
妇产科学 | 5963篇 |
基础医学 | 39710篇 |
口腔科学 | 10650篇 |
临床医学 | 21781篇 |
内科学 | 59125篇 |
皮肤病学 | 5869篇 |
神经病学 | 24889篇 |
特种医学 | 9974篇 |
外国民族医学 | 35篇 |
外科学 | 34485篇 |
综合类 | 2042篇 |
现状与发展 | 1篇 |
一般理论 | 158篇 |
预防医学 | 30251篇 |
眼科学 | 4887篇 |
药学 | 16546篇 |
中国医学 | 900篇 |
肿瘤学 | 16565篇 |
出版年
2023年 | 1292篇 |
2022年 | 2659篇 |
2021年 | 5184篇 |
2020年 | 3535篇 |
2019年 | 5069篇 |
2018年 | 6849篇 |
2017年 | 5346篇 |
2016年 | 5286篇 |
2015年 | 6048篇 |
2014年 | 8333篇 |
2013年 | 10782篇 |
2012年 | 16560篇 |
2011年 | 17266篇 |
2010年 | 8812篇 |
2009年 | 8420篇 |
2008年 | 14081篇 |
2007年 | 14808篇 |
2006年 | 13933篇 |
2005年 | 13966篇 |
2004年 | 12743篇 |
2003年 | 11784篇 |
2002年 | 9477篇 |
2001年 | 8770篇 |
2000年 | 8715篇 |
1999年 | 7752篇 |
1998年 | 2999篇 |
1997年 | 2478篇 |
1996年 | 2509篇 |
1995年 | 2122篇 |
1994年 | 2073篇 |
1993年 | 1877篇 |
1992年 | 5054篇 |
1991年 | 4691篇 |
1990年 | 4373篇 |
1989年 | 4228篇 |
1988年 | 3845篇 |
1987年 | 3512篇 |
1986年 | 3278篇 |
1985年 | 3134篇 |
1984年 | 2278篇 |
1983年 | 1909篇 |
1982年 | 1064篇 |
1981年 | 968篇 |
1980年 | 873篇 |
1979年 | 1736篇 |
1978年 | 1127篇 |
1977年 | 933篇 |
1975年 | 925篇 |
1974年 | 979篇 |
1973年 | 946篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Karl Johnson Katherine W. Saylor Isabella Guynn Karen Hicklin Jonathan S. Berg Kristen Hassmiller Lich 《Genetics in medicine》2022,24(2):262-288
PurposeUnderstanding the value of genetic screening and testing for monogenic disorders requires high-quality, methodologically robust economic evaluations. This systematic review sought to assess the methodological quality among such studies and examined opportunities for improvement.MethodsWe searched PubMed, Cochrane, Embase, and Web of Science for economic evaluations of genetic screening/testing (2013-2019). Methodological rigor and adherence to best practices were systematically assessed using the British Medical Journal checklist.ResultsAcross the 47 identified studies, there were substantial variations in modeling approaches, reporting detail, and sophistication. Models ranged from simple decision trees to individual-level microsimulations that compared between 2 and >20 alternative interventions. Many studies failed to report sufficient detail to enable replication or did not justify modeling assumptions, especially for costing methods and utility values. Meta-analyses, systematic reviews, or calibration were rarely used to derive parameter estimates. Nearly all studies conducted some sensitivity analysis, and more sophisticated studies implemented probabilistic sensitivity/uncertainty analysis, threshold analysis, and value of information analysis.ConclusionWe describe a heterogeneous body of work and present recommendations and exemplar studies across the methodological domains of (1) perspective, scope, and parameter selection; (2) use of uncertainty/sensitivity analyses; and (3) reporting transparency for improvement in the economic evaluation of genetic screening/testing. 相似文献
2.
3.
4.
5.
6.
7.
8.
Selwyn Arlington Headley Nayara Emily Viana Mariana de Mello Zanim Michelazzo Ana Aparecida Correa Xavier Cícero Júlio Silva Costa Felipe Hideki Ogo de Pinho Marcelo Diniz dos Santos 《Transboundary and Emerging Diseases》2020,67(Z2):49-59
Neorickettsia helminthoeca (NH), the agent of salmon poisoning disease or canine neorickettiosis (CN), is a bacterial endosymbiont of the nematode Nanophyetus salmincola, and infections are spreading among specific fish‐eating mammalians. This article describes the pathologic and immunohistochemical findings associated with spontaneous NH‐induced infections in dogs from Southern Brazil. The principal pathologic findings were hypertrophy of Peyer patches and lymphadenopathy with lymphocytic proliferation, chronic interstitial pneumonia, and chronic enteritis associated with positive intralesional immunoreactivity to antigens of NH within macrophages and histiocytes. Positive immunoreactivity against canine parvovirus‐2 (CPV‐2) or/and canine distemper virus was not detected in the evaluated intestinal segments or in the samples from the cerebellum and lungs, respectively, from the dogs evaluated. These findings demonstrated that NH was involved in the enteric, pulmonary, and lymphoid lesions herein described, and provide additional information to confirm the occurrence of this bacterial endosymbiont within this geographical location. It is proposed that chronic pneumonia should be considered as a pathologic manifestation of NH‐induced infections. Additionally, our results show that the occurrences of CN seem to be underdiagnosed in Southern Brazil due to the confusion with the incidence of CPV‐2. 相似文献
9.
10.