全文获取类型
收费全文 | 12902篇 |
免费 | 1043篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 89篇 |
儿科学 | 459篇 |
妇产科学 | 357篇 |
基础医学 | 1725篇 |
口腔科学 | 323篇 |
临床医学 | 1609篇 |
内科学 | 2466篇 |
皮肤病学 | 131篇 |
神经病学 | 1398篇 |
特种医学 | 277篇 |
外国民族医学 | 1篇 |
外科学 | 1200篇 |
综合类 | 114篇 |
一般理论 | 39篇 |
预防医学 | 2035篇 |
眼科学 | 134篇 |
药学 | 851篇 |
中国医学 | 5篇 |
肿瘤学 | 807篇 |
出版年
2024年 | 27篇 |
2023年 | 161篇 |
2022年 | 201篇 |
2021年 | 387篇 |
2020年 | 301篇 |
2019年 | 469篇 |
2018年 | 483篇 |
2017年 | 399篇 |
2016年 | 442篇 |
2015年 | 387篇 |
2014年 | 529篇 |
2013年 | 712篇 |
2012年 | 934篇 |
2011年 | 971篇 |
2010年 | 528篇 |
2009年 | 432篇 |
2008年 | 760篇 |
2007年 | 770篇 |
2006年 | 676篇 |
2005年 | 605篇 |
2004年 | 582篇 |
2003年 | 516篇 |
2002年 | 504篇 |
2001年 | 193篇 |
2000年 | 163篇 |
1999年 | 182篇 |
1998年 | 115篇 |
1997年 | 88篇 |
1996年 | 92篇 |
1995年 | 83篇 |
1994年 | 72篇 |
1993年 | 66篇 |
1992年 | 135篇 |
1991年 | 118篇 |
1990年 | 110篇 |
1989年 | 111篇 |
1988年 | 87篇 |
1987年 | 67篇 |
1986年 | 69篇 |
1985年 | 63篇 |
1984年 | 64篇 |
1983年 | 25篇 |
1982年 | 33篇 |
1980年 | 26篇 |
1979年 | 29篇 |
1978年 | 19篇 |
1977年 | 20篇 |
1975年 | 19篇 |
1972年 | 17篇 |
1968年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Joseph M. Northey Kate L. Pumpa Clare Quinlan Ashley Ikin Kellie Toohey Disa J. Smee Ben Rattray 《Journal of Science and Medicine in Sport》2019,22(5):580-585
Objectives
The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.Design
Pilot randomised-controlled trial.Methods
Seventeen female cancer survivors (mean: 62.9 ± 7.8 years) were randomised into three groups: high-intensity interval training (HIIT, n = 6); moderate-intensity continuous training (MOD, n = 5); or wait-list control (CON, n = 6). The HIIT and MOD groups exercised on a cycle ergometer 3 days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen’s d effect sizes were calculated.Results
All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7 ± 13.2% vs 79.4 ± 12.0%; p = 0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d = 1.28) and MOD had a non-significant 5.6% (d = 0.72) increase, compared to CON which had a 2.6% decrease.Conclusions
This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials. 相似文献2.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse 下载免费PDF全文
3.
4.
5.
Nawf Sharief Judith E. Kingston Vanessa M. Wright Kate Costeloe 《Pediatric hematology and oncology》1991,8(4):323-327
We describe a familial case of Marfan's syndrome with associated intrathoracic stomach detected during the neonatal period. The patient developed a primitive leukemia at 3 months of age. Acute leukemia in a patient with Marfan's syndrome has not previously been reported. 相似文献
6.
F Elferink W J van der Vijgh W W ten Bokkel Huinink J B Vermorken I Klein B Winograd M K Knobf G Simonetti H E Gall J G McVie 《British journal of cancer》1987,56(4):479-483
Pharmacokinetics of the cis-platin analog ethylenediaminemalonatoplatinum(II) (JM-410) was studied in 28 cycles of 19 patients during the phase I study of this drug. The drug was administered intravenously by short-term (10-60 min) infusion. Doses ranged from 20 to 1,200mg m-2. JM-40 was determined in plasma ultrafiltrate and urine by HPLC. Platinum (Pt) concentrations were determined in plasma, plasma ultrafiltrate, urine and red blood cells by atomic absorption spectrometry up to 5 days after administration of the drug. Ultrafilterable Pt could be determined up to 45 days after the infusion in one patient sampled over such a long period. Pharmacokinetics of JM-40 showed a linear behaviour. The final half-life of total Pt in plasma was 4.1 +/- 0.9 days. The disposition of JM-40 was similar to that of ultrafilterable Pt in respect to t1/2 alpha (10 and 13 min), t1/2 beta (44 and 57 min), volumes of distribution Vc (11 and 121) and Vss (17 and 201), systemic clearance (256 and 223 ml min-1), renal clearance (69 and 73 ml min-1) and metabolic clearance (183 and 154 ml min-1). During the first 6 h 27 +/- 9% of the administered dose was excreted as JM-40. Cumulative platinum excretion in the urine amounted to 29 +/- 13% and 60 +/- 13% over the first 6 h, 24 h and 5 days, respectively. The uptake of platinum in red blood cells was limited, comprising only 0.24 +/- 0.12% of the administered dose. Although JM-40 and carboplatin are structurally closely related, pharmocokinetics and toxicity of JM-40 were more similar to cis-platin than to carboplatin. 相似文献
7.
8.
J B Jensen J J Pease R ten Bensel B D Garfinkel 《Journal of the American Academy of Child and Adolescent Psychiatry》1991,30(5):784-790
The ratio of growth hormone response to clonidine and L-dopa challenge was compared in 74 boys: 15 with purported physical abuse, 7 with purported sexual abuse, 13 normal controls, and 39 psychiatric controls. Sexually abused boys demonstrate a statistically significant elevated ratio of growth hormone response to clonidine versus response to L-dopa. Physically abused boys demonstrate lower clonidine/L-dopa growth hormone response ratios compared with controls. These effects widen with increasing physical development. 相似文献
9.
10.
S J Graafsma H Wollersheim H T Droste M A ten Dam L J van Tits J Reyenga J F Rodrigues de Miranda T Thien 《Clinical science (London, England : 1979)》1991,80(4):325-331
1. alpha 2-Adrenoceptors on platelet membranes and beta 2-adrenoceptors on lymphocytes were studied in 24 patients with primary Raynaud's phenomenon and in 24 age- and sex-matched control subjects. In two subgroups, a standardized mental arithmetic test and a finger-cooling test were performed. 2. Baseline blood pressure, heart rate and forearm blood flow did not differ between the two groups. 3. Baseline skin microcirculation (laser Doppler flux) was decreased in primary Raynaud's phenomenon (19 +/- 15 arbitrary units) compared with control subjects (33 +/- 14 arbitrary units) (P less than 0.01). 4. Baseline plasma noradrenaline concentration (2.00 +/- 1.44 versus 1.16 +/- 0.36 nmol/l) and alpha 2-adrenoceptor density (301 +/- 119 versus 210 +/- 82 fmol/mg) were increased in patients with primary Raynaud's phenomenon in comparison with the control subjects. The alpha 2-adrenoceptor density/beta 2-adrenoceptor density ratio in patients with primary Raynaud's phenomenon was, with a value of 0.37 +/- 0.04, higher than in the control subjects, where a value of 0.25 +/- 0.02 was measured (P less than 0.001). Plasma adrenaline concentration, beta 2-adrenoceptor density and the antagonist affinity to both receptor subtypes did not differ between both groups under baseline conditions. 5. Whereas during the finger-cooling test no differences were seen in the responses of the parameters measured, the mental arithmetic test induced an increase in laser Doppler flux in patients with primary Raynaud's phenomenon and a decrease in the control group.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献