全文获取类型
收费全文 | 2228篇 |
免费 | 134篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 132篇 |
妇产科学 | 72篇 |
基础医学 | 322篇 |
口腔科学 | 44篇 |
临床医学 | 199篇 |
内科学 | 483篇 |
皮肤病学 | 32篇 |
神经病学 | 161篇 |
特种医学 | 160篇 |
外国民族医学 | 1篇 |
外科学 | 243篇 |
综合类 | 27篇 |
预防医学 | 209篇 |
眼科学 | 15篇 |
药学 | 108篇 |
中国医学 | 1篇 |
肿瘤学 | 166篇 |
出版年
2022年 | 18篇 |
2021年 | 40篇 |
2020年 | 23篇 |
2019年 | 26篇 |
2018年 | 27篇 |
2017年 | 25篇 |
2016年 | 39篇 |
2015年 | 41篇 |
2014年 | 58篇 |
2013年 | 72篇 |
2012年 | 112篇 |
2011年 | 94篇 |
2010年 | 83篇 |
2009年 | 78篇 |
2008年 | 68篇 |
2007年 | 93篇 |
2006年 | 95篇 |
2005年 | 102篇 |
2004年 | 107篇 |
2003年 | 86篇 |
2002年 | 82篇 |
2001年 | 78篇 |
2000年 | 46篇 |
1999年 | 53篇 |
1998年 | 44篇 |
1997年 | 55篇 |
1996年 | 46篇 |
1995年 | 38篇 |
1994年 | 24篇 |
1993年 | 30篇 |
1992年 | 37篇 |
1991年 | 36篇 |
1990年 | 37篇 |
1989年 | 58篇 |
1988年 | 60篇 |
1987年 | 49篇 |
1986年 | 36篇 |
1985年 | 39篇 |
1984年 | 26篇 |
1983年 | 19篇 |
1982年 | 21篇 |
1981年 | 11篇 |
1980年 | 16篇 |
1979年 | 21篇 |
1978年 | 21篇 |
1977年 | 19篇 |
1976年 | 12篇 |
1972年 | 10篇 |
1971年 | 9篇 |
1968年 | 8篇 |
排序方式: 共有2387条查询结果,搜索用时 15 毫秒
1.
2.
Michael Robson Isabelle Côte Ian Abbs Geoffrey Koffman David Goldsmith 《American journal of transplantation》2003,3(3):324-327
Thrombotic microangiopathy is a rare but important finding in the context of organ transplantation. Acute renal insufficiency in the setting of hemolysis and thrombocytopenia, a triad that constitutes 'hemolytic uremic syndrome', can be associated with, or triggered by, conditions such as verocytotoxin-producing Escherichia coli, viral infections, malignant hypertension, scleroderma, allograft rejection, lupus erythematosus, pregnancy, and medications including mitomycin C, calcineurin inhibitors, and oral contraceptives. After renal transplantation, it can occur, as either a de novo episode, or recurrent disease. Calcineurin inhibitors have long been associated with post-transplantation thrombotic microangiopathy. Sirolimus has been used as a primary immunosuppressant in patients transplanted with a history of earlier hemolytic-uremic syndrome, and also as rescue therapy in patients with calcineurin-inhibitor-associated thrombotic microangiopathy. We describe four cases where there was significant thrombotic microangiopathy in the context of contemporaneous or contiguous calcineurin inhibitor and sirolimus usage. As the intrarenal cyclosporin concentration is thought to be significantly elevated when cyclosporin and sirolimus are used together, this may explain these findings, and mandates caution in their co-administration. 相似文献
3.
4.
5.
6.
A study of 585 patients with acute myocardial infarction (285 with and 300 without cardiac arrest) showed the two groups to differ significantly in terms of clinical, laboratory and electrocardiographic findings. Resuscitation effectiveness depended upon the form of cardiac arrest (chi 2 = 209.25; p less than 0.001). A stable resuscitation effect (survival within and beyond 28 days after the onset of acute myocardial infarction) was achieved in 78.4% of cases of primary ventricular fibrillation, 24.0% of cases of secondary ventricular fibrillation, and 4.9% of asystolia cases. All cases of electromechanical dissociation were fatal. Long-term follow-up showed that 17.3% of patients with cardiac arrest and 21.9% of patients without cardiac arrest died over 4 years (p greater than 0.05). 相似文献
7.
8.
9.
R. R. Beumer M. C. te Giffel E. Spoorenberg F. M. Rombouts 《Epidemiology and infection》1996,117(3):437-442
Using a direct isolation method Listeria spp. were detected in 101 (47.4%) of 213 houses investigated. L. monocytogenes was present in 45 houses (21.1%). Listeria spp. occurred at all sampling sites. Dish-cloths (37%) and surface samples round the drain in the bathroom (27.2%) were most frequently contaminated. Highest numbers (c. 10(4) c.f.u./object) were found in dish-cloths and washing-up brushes. Lower levels (up to 10(3) c.f.u./object) were obtained from kitchen sinks, refrigerator vegetable compartment samples and tooth brushes. In total, 132 isolations of Listeria spp. were made from 871 samples. L. innocua (53%) and L. monocytogenes (41%) were the predominant species in the positive samples. Other Listeria spp. were found in only 6% of the positive samples. 相似文献
10.
Semipermeable Hollow Fiber Membranes in Hepatocyte Bioreactors: A Prerequisite for a Successful Bioartificial Liver? 总被引:10,自引:0,他引:10
Leonard M. Flendrig Anje A. te Velde Robert A.F.M. Chamuleau 《Artificial organs》1997,21(11):1177-1181
Abstract: Recent studies have shown that liver support systems based on viable hepatocytes can prolong life in animal models of acute liver failure. Now the time has come to elucidate the design characteristics that are essential to construct an efficient bioreactor. The gold standard remains the intact liver. Despite the very high cell density in this organ, individual cell perfusion is guaranteed resulting in low diffusional gradients which are essential for optimal mass transfer. These conditions are not met in bioreactors based on hollow fiber membranes. Moreover, the semipermeable membranes can foul and act as a diffusional barrier between the hepatocytes and the blood or plasma of the recipient. We devised a novel bioreactor for use as a bioartificial liver that does not include hollow fiber membranes for blood or plasma perfusion. The device is based on an integral oxygenator and a nonwoven polyester matrix material for hepatocyte culture as small aggregates. The efficacy of this original design was tested in rats with liver ischemia. Preliminary results show statistically significantly improved survival; life was prolonged 100% compared to the control experiments. 相似文献