全文获取类型
收费全文 | 717篇 |
免费 | 38篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 38篇 |
妇产科学 | 3篇 |
基础医学 | 79篇 |
口腔科学 | 9篇 |
临床医学 | 50篇 |
内科学 | 185篇 |
皮肤病学 | 2篇 |
神经病学 | 4篇 |
特种医学 | 312篇 |
外科学 | 16篇 |
综合类 | 13篇 |
预防医学 | 19篇 |
眼科学 | 3篇 |
药学 | 30篇 |
中国医学 | 1篇 |
肿瘤学 | 12篇 |
出版年
2023年 | 1篇 |
2021年 | 7篇 |
2020年 | 1篇 |
2018年 | 6篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 6篇 |
2014年 | 4篇 |
2013年 | 6篇 |
2012年 | 3篇 |
2011年 | 5篇 |
2010年 | 11篇 |
2009年 | 16篇 |
2008年 | 6篇 |
2007年 | 23篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 3篇 |
2003年 | 5篇 |
2002年 | 8篇 |
2001年 | 9篇 |
2000年 | 4篇 |
1999年 | 12篇 |
1998年 | 46篇 |
1997年 | 40篇 |
1996年 | 58篇 |
1995年 | 44篇 |
1994年 | 33篇 |
1993年 | 39篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 10篇 |
1989年 | 31篇 |
1988年 | 36篇 |
1987年 | 28篇 |
1986年 | 25篇 |
1985年 | 39篇 |
1984年 | 20篇 |
1983年 | 22篇 |
1982年 | 26篇 |
1981年 | 24篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 26篇 |
1976年 | 18篇 |
1975年 | 14篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有777条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Alan J.A. McBride Gustavo M. Cerqueira Marc A. Suchard Angela N. Moreira Richard L. Zuerner Mitermayer G. Reis David A. Haake Albert I. Ko Odir A. Dellagostin 《Infection, genetics and evolution》2009,9(2):196-205
Recent serologic, immunoprotection, and pathogenesis studies identified the Lig proteins as key virulence determinants in interactions of leptospiral pathogens with the mammalian host. We examined the sequence variation and recombination patterns of ligA, ligB, and ligC among 10 pathogenic strains from five Leptospira species. All strains were found to have intact ligB genes and genetic drift accounting for most of the ligB genetic diversity observed. The ligA gene was found exclusively in L. interrogans and L. kirschneri strains, and was created from ligB by a two-step partial gene duplication process. The aminoterminal domain of LigB and the LigA paralog were essentially identical (98.5 ± 0.8% mean identity) in strains with both genes. Like ligB, ligC gene variation also followed phylogenetic patterns, suggesting an early gene duplication event. However, ligC is a pseudogene in several strains, suggesting that LigC is not essential for virulence. Two ligB genes and one ligC gene had mosaic compositions and evidence for recombination events between related Leptospira species was also found for some ligA genes. In conclusion, the results presented here indicate that Lig diversity has important ramifications for the selection of Lig polypeptides for use in diagnosis and as vaccine candidates. This sequence information will aid the identification of highly conserved regions within the Lig proteins and improve upon the performance characteristics of the Lig proteins in diagnostic assays and in subunit vaccine formulations with the potential to confer heterologous protection. 相似文献
5.
6.
A randomized controlled trial of electromagnetic therapy in the primary care management of venous leg ulceration 总被引:1,自引:1,他引:0
OBJECTIVE: The aim was to establish the potential efficacy, tolerabilityand side-effect profile of electromagnetic therapy as an adjunctto conventional dressings in the treatment of venous leg ulcers. METHOD: A prospective, randomized, double blind controlled clinicaltrial was carried out in a dedicated leg ulcer clinic basedin one urban general practice. Nineteen patients with leg ulcersof confirmed venous aetiology were assessed. The main outcomemeasures were rate and scale of venous leg ulcer healing, changesin patient-reported pain levels, quality of life, degree ofmobility, side effect profile and acceptability to patientsand staff. RESULTS: Sixty-eight per cent of patients attending this dedicated clinicachieved improvements in the size of their ulcer (4, 21%, healedfully) and in reduced pain levels (P < 0.05) during the trial,despite the chronicity of ulcer histories. Patients treatedwith electromagnetic therapy at 800 Hz were found at day 50to have significantly greater healing (P < 0.05) and paincontrol (P < 0.05) than placebo therapy or treatment with600 Hz. All patients reported improved mobility at the end ofthe study. The electromagnetic therapy was well tolerated bypatients, with no differences between groups in reporting adverseevents, and proved acceptable to staff. CONCLUSION: Despite the small numbers in this pilot study, electromagnetictherapy provided significant gains in the healing of venousleg ulcers and reduction in pain. Keywords. Electromagnetic therapy, RCT, leg ulcers, primary care. 相似文献
7.
8.
9.