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排序方式: 共有104条查询结果,搜索用时 109 毫秒
1.
Zenab Amin Ralitza Gueorguieva Angela Cappiello Kathryn A Czarkowski Stephanie Stiklus George M Anderson Frederick Naftolin C Neill Epperson 《Neuropsychopharmacology》2006,31(11):2489-2497
Despite an abundance of data in animals, there is little research in humans regarding how estrogen and serotonin (5-HT) may interact to influence cognition. Through the use of estrogen treatment (ET) and tryptophan depletion (TRP-D) in a within-subject design involving healthy menopausal women, we have manipulated both estrogen and 5-HT in order to evaluate their individual and joint effects. Although neither manipulation influenced visuospatial learning, a significant interaction suggested that estrogen exerted a protective effect on verbal memory, such that TRP-D impaired performance to a greater extent before the administration of ET. In consonance with this finding, ET was associated with a small, but positive mood effect on the day following active TRP-D. In addition, ET significantly improved letter-cued verbal fluency with and without TRP-D. Finally, time since last menstrual period was significantly associated with verbal memory scores, such that longer length of hypogonadism resulted in decreased verbal memory performance. These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition. 相似文献
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Relationship between electroencephalography and magnetic resonance imaging findings after hypoxic-ischemic encephalopathy at term 总被引:1,自引:0,他引:1
El-Ayouty M Abdel-Hady H El-Mogy S Zaghlol H El-Beltagy M Aly H 《American journal of perinatology》2007,24(8):467-473
Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and mortality. Electroencephalography (EEG) and brain magnetic resonance imaging (MRI) are frequently performed in these infants, but the prognostic value of the combined use of EEG and MRI needs additional exploration. The purpose of this study was to investigate, in neonates with HIE, the role of early EEG and conventional MRI in the prediction of infants at risk for persistent encephalopathy at 18 months of age. Thirty-four term infants with HIE were enrolled in this prospective study. EEG was recorded within the first 72 hours after birth and a brain MRI scan was done between 1 and 4 weeks of age. Denver Developmental Screening Test II was performed at 6, 12, and 18 months of age. Three infants (9%) had mild HIE, 21 infants (62%) had moderate HIE, and 10 infants (29%) had severe HIE. The EEG background was normal, moderately, severely, and extremely discontinuous in eight (24%), three (9%), sixteen (47%), and seven (20%) neonates, respectively. EEG background activities correlated significantly with HIE severity (p = 0.0001). MRI findings significantly correlated with EEG background (p = 0.001). Normal MRI scans and minimal basal ganglia lesions were always associated with normal EEG background. Patients with severe basal ganglia and thalamic lesions in MRI (n = 2) had extreme discontinuous EEG background. For the prediction of poor outcomes, abnormal EEG background activity had a sensitivity (Sn) = 100%, a specificity (Sp) = 100%, positive predictive value (PPV) = 100%, and negative predictive value (NPV) = 100%, whereas values of abnormal MRI scans were Sn of 100%, Sp = 43%, PPV = 82%, and NPV=100%. EEG background activity is the best element to predict abnormal outcomes. Severe basal ganglia and thalamic injuries on MRI scans are associated with poor outcomes. Otherwise, MRI does not contribute to the prediction of outcomes at 18 months of age. 相似文献
3.
A rapidly implemented qualitative study was conducted to investigate the perceptions of women about abortion in Egypt using in-depth interviews with hospitalised patients and focus group discussions with family planning clients and non-contracepting women. The most salient issue confronting the patients (whether the abortion had been spontaneous or induced) was their physical survival. The necessity to return immediately to their daily routines was most troubling to the patients who felt a need to rest and recuperate. The provision of post-abortion contraception was found to be problematic as women believed their bodily balance needed restoring first and that their fertility would not return immediately. The provision of counselling to reduce anxiety and fears, accurate and easily comprehensible information about miscarriage, induced abortion and future fertility and support for the women's need to rest are important aspects of post-abortion care. 相似文献
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Heterocycles containing the indole ring system include some novel pharmacologically active compounds. Isatin and its N-acetylisatin are extremely versatile intermediates in the construction of a variety of heterocyclic systems when reacted with thiosemicarbazide derivatives. Literature survey revealed various interesting reactions of thiocarbohydrazide with cyclic ketones, cyclic 1,2-diketones and isatin. 相似文献
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Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study
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8.
Mahmoud Alhosiny Fayed Hesham El-Sayed Abdel-Hady Mona Mohammed Hafez Osama Saad Salama Youssef Abdelhalim Al-Tonbary 《Hematology/oncology and stem cell therapy》2018,11(2):65-74
Background
The increased survival rate of thalassemic patients has led to unmasking of management related complications which were infrequently encountered.Objective
Study the increased coagulation and platelet activation in children with β-thalassemia, to analyze the factors that lead to such hypercoagulable state and to study pulmonary hypertension (PH) in conjunction with platelet activation and hypercoagulable state in children with β-thalassemia.Methods
36 Egyptian children with β-thalassemia with a mean age of 9.9 years (±4.7 SD). In addition, 20 healthy Egyptian children matched for age and sex were enrolled as a control group. Both were subjected to clinical and laboratory assessments. Echocardiography was done to the patient group and PH was diagnosed based on calculated mean pulmonary artery pressure [MPAP] >25 mmHg.Results
We found that, mean ± SD serum P-selectin level (platelet activator marker) was significantly higher in thalassemic patients (2337 ± 566 pg/ml) in comparison to controls (1467 ± 247 pg/ml) (P < 0.001). Mean serum protein-C and antithrombin-III levels were significantly lower in thalassemic patients (1.2 ± 1.3 µg/ml, 27.3 ± 7.5 mg/dl) in comparison to controls (2.3 ± 1.3 µg/ml, 35.1 ± 4.1 mg/dl) (P = 0.003 and <0.001) respectively. PH was detected in 17 (47.2%) patients and it was significantly associated with splenectomy (P = 0.01) and non-transfusion dependent thalassemia (NTDT) (P = 0.04). PH was positively correlated with serum levels of P-selectin (r = 0.38, P = 0.02), fibrinogen (r = 0.41, P = 0.01) and negatively correlated with serum protein-C level (r = ?0.48, P = 0.003).Conclusion
A chronic hypercoagulable state and platelet activation is present in children with β-thalassemia. Splenectomy and transfusion infrequency are the main risk factors noted to be associated with such hypercoagulable state and platelet activation and consequently the PH among our thalassemic patients. 相似文献9.
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