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Talayev VY Zaichenko IY Babaykina ON Lomunova MA Talayeva EB Nikonova MF 《Clinical and experimental immunology》2005,141(3):440-448
The effects of dexamethasone phosphate and interleukin‐7 upon the proliferation of T‐cells and the production of interferon‐γ in the newborn's cord blood mononuclear cell cultures were studied. The capability of dexamethasone to enhance T‐cell proliferation induced by anti‐CD3 with interleukin‐7 in some newborn cord blood mononuclear cell cultures was identified. Dexamethasone suppressed production of interferon‐γ in 68‐h cell cultures stimulated with anti‐CD3 both in the presence of interleukin‐7 and without it. However, a 68‐h cultivation of newborn blood cells with dexamethasone, anti‐CD3 and interleukin‐7 resulted in the accumulation of T‐lymphocytes capable of producing interferon‐γ after restimulation. As a result of it the amount of interferon‐γ producing CD7+ T‐cells and the concentration of interferon‐γ in cultural supernatants were maximal in the cell cultures incubated with anti‐CD3, interleukin‐7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12‐myristate 13‐acetate and ionomycin. The stimulation of neonatal or adult blood cells by dexamethasone, anti‐CD3 and interleukine‐7 also causes a decrease in the number of naïve T‐cells and central memory cells and an increase in the number of effector memory CD7+CD45RA+CD62L– cells in cultures. It is possible that these effects are caused by the influence of dexamethasone on IL‐7 receptor expression: it is known that IL‐7 receptor alpha‐chain gene is a glucocorticoid‐inducible gene. 相似文献
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Broshevitskaya N. D. Pavlova I. V. Zaichenko M. I. Gruzdeva V. A. Grigoryan G. A. 《Neuroscience and behavioral physiology》2021,51(3):390-401
Neuroscience and Behavioral Physiology - Early proinflammatory stress created by administration of lipopolysaccharide (LPS) (50 μg/kg s.c.) on days 3 and 5 of postnatal life led to decreases... 相似文献
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M. I. Zaichenko G. Kh. Merzhanova A. V. Demina 《Neuroscience and behavioral physiology》2011,41(6):606-612
Rats divided on the basis of a test in which they were presented with the “right” to choose a more valuable but delayed or
a less valuable but immediate reinforcement into “impulsive” and “self-controlled” groups were studied using the “emotional
resonance” method. These experiments showed that none of the rats of the “self-controlled” group, selecting the more valuable
but delayed reinforcement, avoided defensive arousal signals from another individual of the same species, preferring to spend
a large proportion of time in the dark “house.” Most (80%) of the animals of the “impulsive” group spent more than half the
experimental period in the light sector, thus saving the partner from electrical stimulation. It is suggested that there are
several common mechanisms underlying these two types of behavior. 相似文献
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