全文获取类型
收费全文 | 2087篇 |
免费 | 104篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 32篇 |
妇产科学 | 55篇 |
基础医学 | 231篇 |
口腔科学 | 49篇 |
临床医学 | 119篇 |
内科学 | 458篇 |
皮肤病学 | 128篇 |
神经病学 | 180篇 |
特种医学 | 82篇 |
外科学 | 466篇 |
综合类 | 16篇 |
预防医学 | 74篇 |
眼科学 | 26篇 |
药学 | 107篇 |
中国医学 | 1篇 |
肿瘤学 | 162篇 |
出版年
2023年 | 18篇 |
2022年 | 31篇 |
2021年 | 46篇 |
2020年 | 41篇 |
2019年 | 40篇 |
2018年 | 55篇 |
2017年 | 39篇 |
2016年 | 36篇 |
2015年 | 35篇 |
2014年 | 49篇 |
2013年 | 50篇 |
2012年 | 102篇 |
2011年 | 91篇 |
2010年 | 61篇 |
2009年 | 51篇 |
2008年 | 97篇 |
2007年 | 111篇 |
2006年 | 132篇 |
2005年 | 122篇 |
2004年 | 103篇 |
2003年 | 101篇 |
2002年 | 89篇 |
2001年 | 75篇 |
2000年 | 52篇 |
1999年 | 60篇 |
1998年 | 22篇 |
1997年 | 15篇 |
1996年 | 12篇 |
1995年 | 14篇 |
1994年 | 22篇 |
1993年 | 18篇 |
1992年 | 43篇 |
1991年 | 58篇 |
1990年 | 24篇 |
1989年 | 32篇 |
1988年 | 24篇 |
1987年 | 25篇 |
1986年 | 22篇 |
1985年 | 22篇 |
1983年 | 10篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1979年 | 16篇 |
1978年 | 12篇 |
1977年 | 15篇 |
1976年 | 11篇 |
1974年 | 11篇 |
1968年 | 7篇 |
1967年 | 9篇 |
1966年 | 10篇 |
排序方式: 共有2206条查询结果,搜索用时 15 毫秒
1.
Yuki Asada Kazuaki Kanda Kazuyuki Ozeki Toshiro Tanaka Yohei Mizuta Shigeru Kohno 《Nihon Shokakibyo Gakkai zasshi》2006,103(12):1372-1376
Two patients with mesenteric panniculitis are presented. In the first patient, a provisional diagnosis of ileus was made, based on the clinical features and imaging data. Laparotomic findings showed that the ileum was bound tightly by a fibrous strip and dilated, with thickened and swollen mesentery. Incision of the fibrous strip was performed, and the clinical symptoms were improved. The second patient was strongly suspected to have mesenteric panniculitis, from characteristic features on abdominal computed tomography and barium enema. Conservative therapy was effective in this case. We emphasize the variety of clinical courses in mesenteric panniculitis, requiring selection of the most suitable treatment. 相似文献
2.
3.
The effects of cepharanthin on inflammatory parameters such as neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation, were examined. Cepharanthin significantly decreased the levels of O2-, H2O2, and OH. generated by neutrophils. H2O2 and OH. generated in a cell-free, xanthine-xanthine oxidase system were also reduced in the presence of cepharanthin. However, the drug did not affect neutrophil chemotaxis or phagocytosis. The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation. 相似文献
4.
OBJECTIVE: The aim of this study was to evaluate the relationship between the degree of conversion (DC) of composites and the light intensity using LED-curing units and also to determine the amount of exposure required to achieve optimal curing. METHOD: The light outputs of light-curing units and the depths of cure of composites exposed to these units were determined using the methods outlined in modified ISO standards, ISO/TS10650 and ISO 4049, respectively. The distributions of DC in composites were investigated by IR spectra of microareas obtained at various depths from the irradiated surface of thin specimens cut out from the cured composites. IR spectra were measured using a Fourier transform infrared spectrometer equipped with a microscopic unit. DC was calculated from the changes in the amount of C=C double bonds in the IR spectra. RESULTS: The light intensity at various depths through the cured composite was calculated from the attenuation coefficient of each material, obtained from the linear relationship between the depth of cure and the logarithm of the amount of exposure, which is defined as the product of the irradiance and irradiation time. There was a third or fourth order regression relationship between DC and the logarithm of total light energy at a particular depth. SIGNIFICANCE: The minimum light energy required to produce a saturated DC was about 1000 s mW/cm2. 相似文献
5.
Tsuyoshi Shimizu Shigeki Ito Yujiro Kikuchi Masaharu Misaka Tetsuzo Hirayama Shin Ishimaru Akira Yamashina 《European journal of cardio-thoracic surgery》2004,25(4):578-584
OBJECTIVES: Graft failure has been reported when the arterial conduit, such as the internal thoracic artery (ITA) or the right gastroepiploic artery (GEA), is grafted to a lower grade coronary artery stenosis. The shear stress as a significant factor affecting graft patency was compared between the arterial conduit and the saphenous vein graft (SVG) after surgery. METHODS: In 101 patients, 40 ITAs, 27 GEAs and 34 SVGs were examined using a Doppler-tipped guide wire during postoperative angiography. The graft flow volume and shear stress were calculated from velocity and diameter data. The study grafts were classified according to the grade of native coronary artery stenosis: group L had more than 50 up to 75% stenosis, and group H had more than 75% stenosis. Group H consisted of 25 ITAs, 17 GEAs and 21 SVGs, while group L consisted of 15 ITAs, 10 GEAs and 13 SVGs. RESULTS: In group H, graft flow volume did not significantly differ among the ITA (34+/-11 ml/min), GEA (36+/-16 ml/min) and SVG (41+/-15 ml/min), and graft shear stress significantly (ITA vs. GEA P<0.0001; GEA vs. SVG P<0.01) differed among the ITA (16.0+/-4.8dyn/cm(2)), GEA (9.1+/-3.2dyn/cm(2)) and SVG (4.8+/-1.6dyn/cm(2)). In group L, flow volume was lower (P<0.001) in the ITA (18+/-6 ml/min) and GEA (13+/-8 ml/min) than in the SVG (35+/-16 ml/min), and shear stress was significantly (P<0.001) greater in the ITA (13.7+/-4.9dyn/cm(2)) than the GEA (5.6+/-2.0dyn/cm(2)) or SVG (4.6+/-2.0dyn/cm(2)). CONCLUSIONS: These data suggest that shear stress of the ITA is superior and maintained despite the flow volume being reduced by flow competition. Lower shear stress of the GEA for intermediate stenosis may be associated with the development of conduit failure. 相似文献
6.
Hase I.; Oda Y.; Tanaka K.; Mizutani K.; Nakamoto T.; Asada A. 《British journal of anaesthesia》1997,79(6):740-743
We have examined the effect of fentanyl on the pharmacokinetics of
midazolam in patients undergoing orthopaedic surgery. Thirty patients were
allocated randomly to receive fentanyl 200 micrograms and midazolam 0.2 mg
kg-1 (fentanyl group, n = 15) or placebo and midazolam 0.2 mg kg-1 (placebo
group, n = 15) in a double-blind manner for induction of anaesthesia.
Anaesthesia was maintained with nitrous oxide and isoflurane. Systemic
clearance of midazolam was decreased by 30% (P = 0.002) and elimination
half-time was prolonged by 50% (P = 0.04) in the fentanyl group compared
with the placebo group. There were no differences in the distribution
half-time or volume of distribution at steady state between the two groups.
These findings indicate that elimination of midazolam was inhibited by
fentanyl during general anaesthesia.
相似文献
7.
S Minohara S Sasaki K Asada H Muraki T Kodama S Hasegawa M Morita E Tsujii A Takeuchi 《Kyobu geka. The Japanese journal of thoracic surgery》1992,45(12):1106-1108
The patient was a one-year-old boy, who underwent surgery with a diagnosis of atrial septal defect (ASD). During operation, aorto-pulmonary window (A-P window) which had not been detected by the preoperative examinations, was found. Therefore, the A-P window was divided prior to closing ASD. The patient is in good condition six months after the operation. The causes of the inaccurate preoperative diagnosis were discussed. 相似文献
8.
An evaluation of the residual activity of quick-drying agents (alcoholic solutions) used for hygienic hand disinfection is described. We looked for residual efficacy following hand disinfection with soap and water alone or followed by one of two alcoholic handrub lotions supplied from an automatic hand washing machine. The bacterial counts on the hands obtained before and within 2 successive hours after disinfection showed that alcoholic chlorhexidine was the most effective for 10 minutes after contamination of the hands. WELPAS® (alcoholic chlorbenzarconium) followed this in its immediate effect and was better than soap and water alone. There were no significant differences after 30‘ or 120‘ between the three disinfecting methods. 相似文献
9.
Formation and inhibition of a reaction plug in the course of insemination reaction in Drosophila (Diptera) were investigated. When the reaction plug was formed in the vagina, fecundity was significantly reduced in interspecific crosses although the reaction plug did not affect the oviposition in intraspecific crosses. Some phenoloxidase blockers were found to be the effective inhibitors. The formation of the reaction plug was likely to be the consequence of polymerization and/or conformational change(s) of phenol-containing substance(s) involving nearly the same course of the melanization cascade reaction studied as a self-defense system in other insects. 相似文献
10.
S Nishijima T Sugimachi T Higashida Y Asada K Okuda K Murata 《The Journal of dermatology》1992,19(6):356-361
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important causative microorganisms for nosocomial infections. Recently, the incidence of isolation of MRSA has been increasing every year in Japan and is, notably, much more frequently found in inpatients than in outpatients. Therefore, we have done epidemiological studies of MRSA isolated from medical staff, inpatients, and the hospital environment in one ward of our hospital. Thereafter, we examined the antibiotic susceptibility (ABPC, DMPPC, CET, CMZ, IPM, GM, MINO, OFLX, EM, CLDM, VCM), phage typing, and coagulase typing of these MRSA. MRSA were isolated more frequently from anterior nares of inpatients than from doctors and nurses. MRSA were isolated more frequently from the environment near carriers of MRSA. Coagulase type II and phage type N.T. (not typable) were the dominant types of MRSA in our hospital (69% and 61%). MRSA strains were resistant to most antibiotics with a few exceptions (VCM, IPM, CMZ, CET). The high isolation frequency of MRSA in our hospital seems to suggest that inpatients who are carrying MRSA spread MRSA throughout the hospital environment and that the anterior nares of inpatients are the major MRSA harbor. 相似文献