全文获取类型
收费全文 | 1026篇 |
免费 | 72篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 10篇 |
妇产科学 | 8篇 |
基础医学 | 127篇 |
口腔科学 | 39篇 |
临床医学 | 92篇 |
内科学 | 341篇 |
皮肤病学 | 23篇 |
神经病学 | 40篇 |
特种医学 | 55篇 |
外科学 | 133篇 |
综合类 | 6篇 |
预防医学 | 24篇 |
眼科学 | 4篇 |
药学 | 81篇 |
中国医学 | 2篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 9篇 |
2022年 | 16篇 |
2021年 | 27篇 |
2020年 | 19篇 |
2019年 | 25篇 |
2018年 | 23篇 |
2017年 | 18篇 |
2016年 | 35篇 |
2015年 | 24篇 |
2014年 | 38篇 |
2013年 | 56篇 |
2012年 | 78篇 |
2011年 | 70篇 |
2010年 | 42篇 |
2009年 | 44篇 |
2008年 | 58篇 |
2007年 | 64篇 |
2006年 | 51篇 |
2005年 | 44篇 |
2004年 | 44篇 |
2003年 | 57篇 |
2002年 | 37篇 |
2001年 | 15篇 |
2000年 | 27篇 |
1999年 | 29篇 |
1998年 | 11篇 |
1997年 | 10篇 |
1996年 | 8篇 |
1995年 | 5篇 |
1994年 | 10篇 |
1993年 | 2篇 |
1992年 | 16篇 |
1991年 | 12篇 |
1990年 | 7篇 |
1989年 | 11篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1975年 | 2篇 |
1972年 | 2篇 |
1970年 | 3篇 |
1969年 | 4篇 |
1967年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有1110条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
A Takahama 《Nippon Seikeigeka Gakkai zasshi》1990,64(4):271-281
The purpose of this study was to investigate the initial changes and pathological process of osteoarthritis in male C57 black mice (Silberberg), which develop spontaneous osteoarthritic lesions in the knee joints. The initial event in the development of the lesions was the slight loss of glycosaminoglycans in the articular cartilage matrix of the tibia, adjacent to the free margin of the anterior segment of the meniscus at 3 months of age. Microscopy under polarized light revealed irregularity of the tangential layer in the corresponding area at 6 months of age. Horizontal cleft along the tidemark, defect of cartilage and eburnation of subchondral bone later developed. Osteoarthritic changes were observed in all mice aged 18 and 24 months. However, no fibrillation of the cartilage matrix, chondrocyte clustering, osteophyte formation or synovitis was observed, probably because of the small joint and poor reparative ability in the mouse. 相似文献
5.
Shinji Hirai Yoshiharu Hamanaka Norimasa Mitsui Shinnosuke Uegami Yousuke Matsuura 《Annals of thoracic and cardiovascular surgery》2007,13(5):331-334
We report on the rare and surgical treatment of a senile patient of infected intralobar pulmonary sequestration. A 56-year-old male who had complained of headache, vomiting, cough, sputum production, and high fever was admitted to our hospital. Chest computed tomography (CT) showed an infected intralobar pulmonary sequestration as an 8x6 cm cystic mass with multiple air-fluid cavities in the left lower basal segment and severe pneumonia in the left upper and lower lobes around the mass. A 3-D CT showed an aberrant artery entering the consolidation from the descending aorta. A standard lower lobectomy was performed with a ligation of the aberrant artery with a diameter of 1 cm supplying the posterior segment of the left lower lobe. A histological examination of the lung revealed acute and chronic broncho-bronchiolitis with cystic dilatation consistent with intralobar pulmonary sequestration. We discuss the characters of senile patients compared with juvenile patients, with reference to a collective review of patients older than 50 reported in the literature. 相似文献
6.
7.
We previously found that autoantibodies against mouse lysozyme (ML) were strongly induced in normal BALB/c mice when immunized with mutant ML that has triple mutations rendering the dominant T-cell epitope of hen egg lysozyme (HEL), HEL 107-116. As T cells specific for HEL 107-116 were primed in these mice, the anti-ML immunoglobulin G (IgG) responses would be the result of collaborations between autoreactive B cells specific for ML and T cells specific for HEL 107-116. Serum IgG responses against ML were dominantly focused on the ML 14-69 region, indicating that B cells responding to the epitope escape tolerance. In the present study, we prepared several monoclonal antibodies (mAbs) specific for ML 14-69 and examined their antigen specificities in detail, to characterize the nature of the remaining B-cell repertoire specific for ML. mAbs specific for ML 14-69 interacted weakly with soluble, native ML, but the interactions were strengthened by denaturation of ML. The apparent affinity constants between these mAbs and ML showed an increase, ranging from six- to 80-fold, by denaturation of ML. Therefore, these mAbs were more specific for the denatured determinant than for the determinant in the native structure. These results indicate that a substantial number of autoreactive B cells, specific for the unfolded conformation of ML, escape tolerance and are dominantly involved in the autoantibody response to ML. Our finding provides important information to understand the naturally occurring autoreactive B-cell repertoire in normal mice. 相似文献
8.
9.
Kazumichi Kawakubo Hiroyuki Isayama Yousuke Nakai Naoki Sasahira Hirofumi Kogure Takashi Sasaki Kenji Hirano Minoru Tada Kazuhiko Koike 《Gut and liver》2012,6(3):399-402
Patients with pancreatic cancer frequently suffer from both biliary and duodenal obstruction. For such patients, both biliary and duodenal self-expandable metal stent placement is necessary to palliate their symptoms, but it was difficult to cross two metal stents. Recently, endoscopic ultrasonography-guided choledochoduodenostomy (EUS-CDS) was reported to be effective for patients with an inaccessible papilla. We report two cases of pancreatic cancer with both biliary and duodenal obstructions treated successfully with simultaneous duodenal metal stent placement and EUS-CDS. The first case was a 74-year-old man with pancreatic cancer. Duodenoscopy revealed that papilla had been invaded with tumor and duodenography showed severe stenosis in the horizontal portion. After a duodenal uncovered metal stent was placed across the duodenal stricture, EUS-CDS was performed. The second case was a 63-year-old man who previously had a covered metal stent placed for malignant biliary obstruction. After removing the previously placed metal stent, EUS-CDS was performed. Then, a duodenal covered metal stent was placed across the duodenal stenosis. Both patients could tolerate a regular diet and did not suffer from stent occlusion. EUS-CDS combined with duodenal metal stent placement may be an ideal treatment strategy in patients with pancreatic cancer with both duodenal and biliary malignant obstruction. 相似文献
10.
Hiroyuki Miyahara Dai Shida Hiroki Matsunaga Yukiko Takahama Sachio Miyamoto 《World journal of gastroenterology : WJG》2013,19(4):604-606
Emphysematous cholecystitis is a rare variant of acute cholecystitis with a high mortality rate.The combination of emphysematous cholecystitis and pneumoperitoneum is also rare.We herein describe a case of emphysematous cholecystitis with massive gas in the abdominal cavity.A 77-year-old male presented with epigastric pain and lassitude lasting for one week.A computed tomography scan demonstrated massive gas in the abdominal cavity.Gas was also detectable inside the gallbladder.Massive ascites as well as a pleural effusion were also detected.Under the diagnosis of perforation of the digestive tract,we performed emergency surgery.Beyond our expectations,the perforation site was not in the alimentary tract,but rather in the gallbladder.We then diagnosed the patient with emphysematous cholecystitis with perforation,and performed cholecystectomy.A pathological examination of the resected gallbladder revealed necrosis in the mucosa and thinning of the wall.Cultures of the ascites detected Clostridium perfringens,a gas-producing microorganism. 相似文献