全文获取类型
收费全文 | 2814篇 |
免费 | 127篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 27篇 |
妇产科学 | 33篇 |
基础医学 | 291篇 |
口腔科学 | 88篇 |
临床医学 | 180篇 |
内科学 | 735篇 |
皮肤病学 | 55篇 |
神经病学 | 110篇 |
特种医学 | 104篇 |
外科学 | 647篇 |
综合类 | 4篇 |
预防医学 | 66篇 |
眼科学 | 52篇 |
药学 | 199篇 |
中国医学 | 4篇 |
肿瘤学 | 333篇 |
出版年
2023年 | 19篇 |
2022年 | 15篇 |
2021年 | 47篇 |
2020年 | 29篇 |
2019年 | 31篇 |
2018年 | 48篇 |
2017年 | 37篇 |
2016年 | 43篇 |
2015年 | 49篇 |
2014年 | 61篇 |
2013年 | 68篇 |
2012年 | 120篇 |
2011年 | 123篇 |
2010年 | 65篇 |
2009年 | 66篇 |
2008年 | 135篇 |
2007年 | 138篇 |
2006年 | 160篇 |
2005年 | 144篇 |
2004年 | 175篇 |
2003年 | 125篇 |
2002年 | 105篇 |
2001年 | 105篇 |
2000年 | 101篇 |
1999年 | 91篇 |
1998年 | 40篇 |
1997年 | 27篇 |
1996年 | 28篇 |
1995年 | 32篇 |
1994年 | 25篇 |
1993年 | 21篇 |
1992年 | 61篇 |
1991年 | 75篇 |
1990年 | 78篇 |
1989年 | 62篇 |
1988年 | 74篇 |
1987年 | 60篇 |
1986年 | 41篇 |
1985年 | 46篇 |
1984年 | 40篇 |
1983年 | 27篇 |
1982年 | 6篇 |
1980年 | 6篇 |
1979年 | 13篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1970年 | 8篇 |
1968年 | 6篇 |
1967年 | 5篇 |
1966年 | 12篇 |
排序方式: 共有2946条查询结果,搜索用时 0 毫秒
1.
Prognostic factors in the treatment of hepatocellular carcinoma with transcatheter arterial embolization and arterial infusion. 总被引:8,自引:0,他引:8
Y Yamashita M Takahashi Y Koga R Saito S Nanakawa Y Hatanaka N Sato K Nakashima J Urata K Yoshizumi 《Cancer》1991,67(2):385-391
From January 1986 to December 1988, a prospective trial of transcatheter arterial treatment was carried out for hepatocellular carcinoma (HCC). Two hundred seventy-five patients were included. Okuda's staging system was employed. Patients with Stage I and II HCC were treated by transcatheter arterial embolization (TAE) with a gelatin sponge containing an anti-cancer agent (protocol 1a); a gelatin sponge and iodized oil mixed with an anti-cancer agent (protocol 1b); or iodized oil mixed with an anti-cancer agent (protocol 2). Patients with Stage III HCC were treated with iodized oil with anti-cancer agent (protocol 2). As an exception, patients with an unsuccessful superselective catheterization into the proper hepatic artery by Seldinger technique or obstruction of the main trunk of the portal vein were treated with percutaneous transcatheter arterial infusion into the common hepatic artery regardless of stage (protocol 3). Tumor type and extension, area of tumor involvement, portal vein involvement, method of treatment, and presence of ascites and icterus were found to be the significant factors for an initial response to therapy. Treatment method was the most important factor. Respective survival rates at 1 and 2 years were 70.9% and 55.3% for protocol 1a; 62.3% and 43.8% for protocol 1b; 37.8% and 18.3% for protocol 2; and 16.5% and 0% for protocol 3. Many factors proved to significantly influenced prognosis; however, tumor type had the most important prognostic significance followed by AFP value, ascites, treatment protocol, and area of tumor involvement. 相似文献
2.
3.
Yuki Izawa Masanori Yoshizumi Keisuke Ishizawa Yoshiko Fujita Shuji Kondo Shoji Kagami Kazuyoshi Kawazoe Koichiro Tsuchiya Shuhei Tomita Toshiaki Tamaki 《Hypertension research》2007,30(11):1107-1117
Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family. Recently, several studies have suggested that BMK1 plays an important role in the pathogenesis of cardiovascular disease. To clarify the pathophysiological significance of BMK1 in the process of vascular remodeling, we explored the molecular mechanisms of BMK1 activation in vascular smooth muscle cells (VSMCs). From the results of co-immunoprecipitation and immunoblotting analyses, it was found that platelet-derived growth factor (PDGF), a known potent mitogen, activated BMK1 and triggered the Gab1-SHP-2 interaction in rat aortic smooth muscle cells (RASMCs). The abrogation of SHP-2 phosphatase activity by transfection of the SHP-2-C/S mutant suppressed PDGF-stimulated BMK1 activation. Infection with an adenoviral vector expressing dominant-negative MEK5alpha, which can suppress PDGF-stimulated BMK1 activation to the control level, inhibited PDGF-induced RASMC migration. Moreover, we observed an increase of BMK1 activation in injured mouse femoral arteries. From these findings, it is suggested that BMK1 activation leads to VSMC migration induced by PDGF via Gab1-SHP-2 interaction, and that BMK1-mediated VSMC migration may play a role in the pathogenesis of vascular remodeling. 相似文献
4.
Tadamasa Miyauchi Hiroshi Takiya Toshihiko Sawamura Eiji Murakami 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(4):206-209
Pericardial abscess is rare in healthy individuals, especially the amebic type. We report a case of pericardial abscess and
cardiac tamponade due to intrapericardial rupture of an amebic liver abscess. A 31-year old Japanese male complained of fever
to a local hospital. A liver mass was discovered in his left hepatic lobe by an abdominal echogram. He was referred to the
internal department of our hospital and was treated with quinolone antibiotics. Two weeks after medication, he suddenly complained
of epigastralgia and severe orthopnea and was admitted. Abdominal computed tomographic scan showed an enlarged liver mass,
and massive pericardial effusion suggested cardiac tamponade. He underwent an emergency subxiphoid partial pericardiectomy
under local anesthesia. 1,000 ml of light brownish fluid was removed and his condition improved. Although no ameba was cultivated
from the pus, the amebic serological test was positive. Metronidazole was administered and the patients was discharged 31
days after surgery. 相似文献
5.
6.
To investigate the chewing patterns of patients with TMJ disorders, analysis of mandibular movement was performed in 25 normal subjects and 150 patients with stomatognathic dysfunction using the Sirognathograph analyzing system. Patients with TMJ disorders demonstrated different chewing patterns than those of normal subjects. Chewing patterns in the frontal, horizontal, and sagittal projections were classified into four, two, and two different patterns, respectively, and each distinct chewing pattern appeared to be associated with a specific TMJ disorder. 相似文献
7.
8.
Eighty-six patients with renal cell carcinoma underwent radical nephrectomy in Chiba Cancer Center Hospital. Fifteen of the 86 patients developed bone metastases. Seven of the 15 patients with bone metastases had received chemotherapy and radiotherapy. Six of the 15 patients underwent surgical treatment and two received radiotherapy alone. Of the six patients treated surgically for bone metastases, two patients were treated with wide resection and the remaining four patients underwent excision of the metastatic lesions in combination with radiotherapy, chemotherapy or immunotherapy. One of the two patients who underwent wide resection of a pelvic bone lesion is alive without evidence of disease for 6 years and 4 months. Another patient who underwent wide resection of femoral bone lesion survived for 14 years and 2 months but died of recurrent cancer. Pathologic findings of renal cell carcinoma in the long-time survivors showed adenocarcinoma of alveolar type of clear cell subtype and in grade 1. Wide resection of bone metastases of renal cell carcinoma can significantly prolong the survival time and improve the quality of life of the patients. 相似文献
9.
Shigeki Ohgitani Akimitsu Miyauchi Yasuyuki Takagi Yoshio Fujii Takuo Fujita Misa Nakamura Zhi-qiang Zhang Liang Shan Mitsuyo Sasaki Ryuichi Tsukino Toyoharu Yokoi Kennichi Kakudo Tomitaka Nakayama Junya Toguchida Hiroshi Kanoe Shinichi Aizawa Masao S. Sasaki Takashi Nakamura M. Suda K. Tanaka Y. Ogawa N. Tamura A. Yasoda H. Itoh M. Uehira N. Nishimoto T. Takigawa K. Shiota K. Nakao 《Journal of bone and mineral metabolism》1997,15(3):165-171
10.