全文获取类型
收费全文 | 30556篇 |
免费 | 1424篇 |
国内免费 | 203篇 |
专业分类
耳鼻咽喉 | 353篇 |
儿科学 | 435篇 |
妇产科学 | 562篇 |
基础医学 | 4006篇 |
口腔科学 | 685篇 |
临床医学 | 2078篇 |
内科学 | 8381篇 |
皮肤病学 | 394篇 |
神经病学 | 2507篇 |
特种医学 | 940篇 |
外科学 | 5367篇 |
综合类 | 120篇 |
一般理论 | 1篇 |
预防医学 | 883篇 |
眼科学 | 398篇 |
药学 | 2025篇 |
中国医学 | 76篇 |
肿瘤学 | 2972篇 |
出版年
2022年 | 201篇 |
2021年 | 478篇 |
2020年 | 281篇 |
2019年 | 327篇 |
2018年 | 494篇 |
2017年 | 375篇 |
2016年 | 458篇 |
2015年 | 484篇 |
2014年 | 679篇 |
2013年 | 856篇 |
2012年 | 1300篇 |
2011年 | 1478篇 |
2010年 | 825篇 |
2009年 | 767篇 |
2008年 | 1452篇 |
2007年 | 1498篇 |
2006年 | 1472篇 |
2005年 | 1464篇 |
2004年 | 1469篇 |
2003年 | 1503篇 |
2002年 | 1557篇 |
2001年 | 990篇 |
2000年 | 1023篇 |
1999年 | 915篇 |
1998年 | 454篇 |
1997年 | 364篇 |
1996年 | 312篇 |
1995年 | 286篇 |
1994年 | 282篇 |
1993年 | 243篇 |
1992年 | 666篇 |
1991年 | 686篇 |
1990年 | 591篇 |
1989年 | 600篇 |
1988年 | 587篇 |
1987年 | 537篇 |
1986年 | 462篇 |
1985年 | 456篇 |
1984年 | 353篇 |
1983年 | 280篇 |
1982年 | 148篇 |
1980年 | 138篇 |
1979年 | 258篇 |
1978年 | 166篇 |
1977年 | 150篇 |
1974年 | 136篇 |
1972年 | 150篇 |
1971年 | 137篇 |
1969年 | 144篇 |
1967年 | 140篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Yosuke Homma Takashi Shiga Hiraku Funakoshi Dai Miyazaki Atsushi Sakurai Yoshio Tahara Ken Nagao Naohiro Yonemoto Arino Yaguchi Naoto Morimura 《The American journal of emergency medicine》2019,37(2):241-248
Objective
This study assessed the association between the timing of first epinephrine administration (EA) and the neurological outcomes following out-of-hospital cardiac arrests (OHCAs) with both initial shockable and non-shockable rhythms.Methods
This was a post-hoc analysis of a multicenter prospective cohort study (SOS-KANTO 2012), which registered OHCA patients in the Kanto region of Japan from January 2012 to March 2013. We included consecutive adult OHCA patients who received epinephrine. The primary result included 1-month favorable neurological outcomes defined as cerebral performance category (CPC) 1 or 2. Secondary results included 1-month survival and return of spontaneous circulation (ROSC) after arrival at the hospital. Multivariable logistic regression analysis determined the association between delay per minute of the time from call to first EA in both pre- or in-hospital settings and outcomes.Results
Of the 16,452 patients, 9344 were eligible for our analyses. In univariable analysis, the delay in EA was associated with decreased favorable neurological outcomes only when the initial rhythm was a non-shockable rhythm. In multivariable analyses, delay in EA was associated with decreased ROSC (adjusted odds ratio [OR] for one minute delay, 0.97; 95% confidence interval [CI], 0.96–0.98) and 1-month survival (adjusted OR, 0.95; 95% CI, 0.92–0.97) when the initial rhythm was a non-shockable rhythm, whereas during a shockable rhythm, delay in EA was not associated with decreased ROSC and 1-month survival.Conclusions
While assessing the effectiveness of epinephrine for OHCA, we should consider the time-limited effects of epinephrine. Additionally, consideration of early EA based on the pathophysiology is needed. 相似文献5.
6.
7.
Koji Saito Takashi Saito Sumio Kawada 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1176, 1179-1176, 1180
8.
Masahiro Yamauchi Hiroko Kusano Etsuko Saito Takeshi Iwata Masashi Nakakura Yasuki Kato Takaaki Uochi Shiro Akinaga Noboru Aoki 《Journal of controlled release》2006,114(2):268-275
Previously, we demonstrated that wrapping dextran fluorescein anionic/cationic lipid complexes with neutral lipids produced a stable formulation that markedly increased the duration of the compound in plasma after intravenous administration to rats. The improved drug-delivery properties of the wrapped liposomes (WL) relative to other formulations suggested that this technology could offer important advantages for the administration of other polyanionic drugs, including antisense oligodeoxynucleotides (ODN). In the present study, we investigated the value of WL for formulating fluorescence-labeled phosphorothioated ODN (F-ODN). WL encapsulating F-ODN/cationic lipid complexes were prepared efficiently using similar methodology to that used in our earlier study. Studies confirmed that these WL were stable in vitro. Following intravenous administration to mice, free F-ODN and naked F-ODN/cationic lipid complexes were rapidly eliminated whereas administration of the WL resulted in high blood concentrations of drug that were maintained for several hours. Additional studies were conducted in mice that were inoculated with tumor cells (Caki-1 xenograft model, human kidney); in these experiments, intravenous administration of WL delivered 13 times more F-ODN to the tumor site than achieved after injection of free F-ODN. 相似文献
9.
Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta. 总被引:1,自引:0,他引:1
Mechanisms underlying beta-adrenoceptor (beta-AR)-mediated vascular relaxation were studied in the isolated rat abdominal aorta. In the endothelium-denuded helical preparations, a non-selective beta-AR agonist isoprenaline elicited a concentration-dependent relaxation. In the absence of beta-AR antagonists, isoprenaline-induced relaxation was not practically affected by an adenylyl cyclase inhibitor SQ 22,536 (300 microM), but was strongly diminished by high-KCl (80 mM). Isoprenaline-induced relaxation in the presence of SQ 22,536 was significantly diminished by iberiotoxin (IbTx, 0.1 microM), but was not affected by 4-aminopyridine (4-AP, 3 mM). Isoprenaline-induced relaxation was not also affected by SQ 22,536 (300 microM) even in the presence of CGP20712A (a beta(1)-selective antagonist) and ICI-118,551 (a beta(2)-selective antagonist) (0.1 microM for each), but was strongly diminished by high-KCl. By contrast, SQ 22,536-resistant, isoprenaline-induced relaxation in the presence of CGP20712A plus ICI-118,551 was not affected by IbTx (0.1 microM), but was inhibited significantly by 4-AP (3 mM). These results suggest that in rat abdominal aortic smooth muscle: 1) both beta(1)-/beta(2)-AR- and beta(3)-AR-mediated relaxations substantially involve cAMP-independent mechanisms; 2) beta(1)-/beta(2)-AR-mediated, cAMP-independent relaxant mechanisms are partly attributed to the large-conductance, Ca (2+)-sensitive K(+) (MaxiK, BK) channel whereas beta(3)-AR-mediated relaxant mechanisms are attributed to K(v) channel. 相似文献