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排序方式: 共有713条查询结果,搜索用时 46 毫秒
1.
过度训练的病理生理及康复 Ⅰ.大鼠过度训练模型的建立 总被引:16,自引:1,他引:15
实验表明,运用大鼠跑台运动,以心电图、体重、饮食量、精神状况、毛发脱落、尿蛋白、血清睾酮、皮质醇等为监测指标建立大鼠过度训练模型的方法是可行的。本文并首次模拟出大鼠运动性心律失常心电图。 相似文献
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As an ongoing effort to elucidate the mechanisms involved in the calcium-dependent fertility regulation process, the viscoelastic properties of the mucus obtained from lamb cervix and human semen, as well as their water and total protein contents after exposure to EDTA, a chelating agent, or Nonoxynol-9 (N-9), a spermicidal agent, were examined. The viscosity was measured using a Cone Plate Digital Viscometer, while the water and total protein contents were determined by the lyophilization process and the Lowry method, respectively. The significant changes in the rheological properties of mucus, such as its viscosity and the water content, upon exposure to EDTA were demonstrated. The viscosity of cervical mucus and human semen were significantly increased by EDTA treatment (as compared to the controls): lamb cervical mucus (2.9 ± 0.3 vs. 2.2 ± 0.3 cps) and human semen (5.0 ± 0.3 vs. 4.3 ± 0.3 cps), respectively. The hydration rate was decreased by EDTA treatment as compared with the control (93.6 ± 0.7 vs. 96.8 ± 0.8%). Among tested samples, the reduction in the percentage of sperm penetration through the cervical mucus was the highest in the mucus containing EDTA, which had the lowest water content (93.6 ± 0.7%), indicating that there is a positive relationship between the hydration rate of the cervical mucus and its ability to permit the penetration of spermatozoa. This result indicates that spermicidal activity exerted by high concentrations of EDTA is in part due to its effect on the rheological properties of cervical mucus or semen. 相似文献
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Anulus fibrosus in bulging intervertebral disks 总被引:1,自引:0,他引:1
In this investigation the association of radial tears of the anulus fibrosus and bulging of the intervertebral disk was studied. An index of disk bulging was measured in sagittal anatomic sections in 149 lumbar disks from 31 cadavers. The indexes of disk bulging were correlated with stages of disk development and the presence of an annular tear. The largest disk-bulging indexes were always associated with radial tears of the anulus. Eighty-four percent of the disks with radial tears had disk-bulging indexes greater than 2.5 mm. Most normal adult disks had an index of less than 2.5 mm. The results challenge the concept that the anulus fibrosus is intact in bulging disks, although ruptured in herniated disks. 相似文献
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乳腺癌的X线诊断(附186例分析) 总被引:3,自引:0,他引:3
本文搜集经手术病理证实的186例乳腺癌,分析了乳癌的发病年龄与乳腺类型的关系,讨论了乳癌的各种X线表现,着重探讨了乳腺癌几种病理类别的X线表现特点,作者将乳腺癌的X线表现归纳为四型:肿块型(又分为团块形,结节形和不规则形),浸润型,钙化型和结构紊乱型,联系其病理结构,提出诊断要点以提高诊断。 相似文献
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Chien Yie W. Chien Te-yen Bagdon Robert E. Huang Yih C. Bierman Robert H. 《Pharmaceutical research》1989,6(12):1000-1010
Several transdermal contraceptive device (TCD) formulations were developed to provide a dual-controlled transdermal delivery of levonorgestrel (LN), a potent progestin, and 17-estradiol (E2), a natural estrogen. Using a sensitive HPLC method, the in vitro release and skin permeation profiles of LN and E2 from various TCD formulations were simultaneously characterized in the hydrodynamically well-calibrated Valia–Chien skin permeation cells and both were found to follow zero-order kinetics. The rates of drug release and skin permeation were observed to vary significantly depending upon some formulation parameters. Six-month stability studies were performed on seven formulations at room and elevated temperatures (37 and 45°C), and two (Formulations 4 and 5) were found to be acceptable, based on drug recovery, release rate, and skin permeation rate data. Judging from the 6-month accelerated stability studies, it is projected these two formulations will have shelf-life of at least 2 years. As a result of development of an efficient manufacturing process, Formulation 4 was selected for further evaluation. One-week primary skin irritation evaluation in 6 rabbits indicated that Formulation 4 is nonirritating, and it was thus selected for Phase I clinical bioavailability/dose proportionality studies in 12 healthy female volunteers of child-bearing age. Results of pharmacokinetic and pharmacodynamic analyses demonstrated that it is capable of achieving and maintaining a steady-state serum level of LN throughout the 3-week treatment period by weekly applications of one or two TCD patches (10 or 20 cm2). A dose proportionality was obtained in the serum drug levels, daily dose delivered, and contraception efficacy. An excellent correlation was obtained for the rates of transdermal delivery determined by the in vitro studies using human cadaver skin, the in vivo studies in rabbits, and the clinical studies in living subjects. 相似文献
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本文报道以RDS立体图作为检测图形,用液晶开关实现其三维立体显示的一些探索性研究,用液晶开关眼镜作为立体图的同步分离部件。使得本系统建立于继时法成像的基础上,因而消除了“红绿竞争”等影响检出精度的因素;系统采用帧频作为同步切换的总控信号,使CRT的视页切换与液晶眼镜开关同步,为此而开发出的显示寄存器编程技术解决了CRT视页切换的超高速要求。 相似文献