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Yemisi Olukemi Adesiji 《Central European Journal of Medicine》2010,5(4):470-474
Arcobacter spp. are emerging food borne pathogens associated with prolonged diarrhea and occasional systemic infections such as bactereamia
and peritonitis in humans. Information on faecal shedding patterns to assess the potential role they play within the intestine
however, is lacking. This study was designed to investigate faecal shedding of local isolates of Arcobacter spp. Using real time PCR for confirmation, A. cryaerophilus and A. butzleri were isolated from the stool of healthy chickens. Pathogenicity of the organisms was tested by administering a single oral
challenge of 102–109 cfu/ml to 45 healthy adult male albino rats divided equally among 5 groups. Uninfected rats were used
as the control group. A. cryaerophilus and A. butzleri produced infection in 100% of the animals. Experimental infection was dose dependent and caused diarrheal illness and faecal
shedding was noted up to 5 weeks post infection. The present study demonstrates that rats can act as a reservoir and potential
source of Arcobacter infection in humans and animals exposed to this pathogen. 相似文献
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Sutton AJ Donegan S Takwoingi Y Garner P Gamble C Donald A 《Journal of clinical epidemiology》2009,62(3):241-251
ObjectiveTo consider the use of statistical methods that aim to prioritize the updating of a collection of systematic reviews based on preliminary literature searches.Study Design and SettingA new simulation-based method estimating statistical power and the ratio of the weights assigned to the predicted new and old evidence, and the existing Barrowman n approach is considered. Using only information on the numbers of subjects randomized in the “new” trials, these were applied retrospectively, by removing recent studies, to existing systematic reviews from the Cochrane Infectious Diseases Group.ResultsTwelve systematic reviews were included. When the removed studies were reinstated, inferences changed in five of them. These reviews were ranked, in order of update priority, 1, 2, 3, 4, and 11 and 1, 2, 3, 4, and 12 by the Barrowman n and simulation-based power approaches, respectively. The low ranking of one significant meta-analysis by both methods was due to unexpectedly favorable results in the reinstated study.ConclusionThis study demonstrates the feasibility of the use of analytical methods to inform update prioritization strategies. Under conditions of homogeneity, Barrowman's n and simulated power were in close agreement. We encourage further, prospective, evaluation of these methods. 相似文献
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Olukemi O Tongo Adebola E Orimadegun Olusegun O Akinyinka 《BMC pregnancy and childbirth》2011,11(1):1-7
Background
To investigate the relation between maternal thyroid function and the outcome of external cephalic version (ECV) in breech presentation.Methods
Prospective cohort study in 141 women (≥ 35 weeks gestation) with a singleton fetus in breech. Blood samples for assessing thyroid function were taken prior to ECV. Main outcome measure was the relation between maternal thyroid function and ECV outcome indicated by post ECV ultrasound.Results
ECV success rate was 77/141 (55%), 41/48 (85%) in multipara and 36/93 (39%) in primipara. Women with a failed ECV attempt had significantly higher TSH concentrations than women with a successful ECV (p < 0.001). Multiple logistic regression showed that TSH (OR: 0.52, 95% CI: 0.30-0.90), nulliparity (OR: 0.11, 95% CI: 0.03-0.36), frank breech (OR: 0.30, 95% CI: 0.10-0.93) and placenta anterior (OR: 0.31, 95% CI: 0.11-0.85) were independently related to ECV success.Conclusions
Higher TSH levels increase the risk of ECV failure.Trial registration number
ClinicalTrials.gov: NCT00516555 相似文献6.
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A survey of 104 sexually active young females tested on on cervico-vaginal swabs showed that 26 of the females (25%) had vulvovaginal
candidiasis with a species distribution of Candida isolates accounting for 13 (50%) with C. albicans, 6 (23%) with C. glabrata, 1 (4%) with C. krusei, and 6 (23%) with C. tropicalis. Of the 26 (25 %) subjects that were positive for VVC, 8 (7.8 %) were symptomatic and 18 (18.8 %) were asymptomatic. However,
distribution among different age groups revealed an increase in the 23–27 age group. The comparative analysis of sensitivity
of the given fungi to the number of antimycotic preparations used revealed the following: in fluconazole, 2 (7.8%) isolates
were sensitive, 5 (19.2%) were susceptible and dose dependent, and 19 (73%) were resistant. For voriconazole, 4 (18.4%) isolates
were sensitive, 6 (23.1%) were susceptible and dose dependent, and 16 (61.5%) were resistant. For nystatin, 5 (19.2%) isolates
were sensitive, 10 (38.5%) were susceptible and dose dependent, and 11 (42.3%) were resistant. It appears that Candida isolates have a variable resistance response, but 19 (73%) had maximum resistance of the isolated fungi of the genus Candida to fluconazole. Therefore, further studies on the evaluation of combination therapy should be considered for a better outcome
in treatment of vulvovaginal candidiasis. 相似文献
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Kolawole Oluseyi Akande Olukemi Adekanmbi 《Journal of immunoassay & immunochemistry》2020,41(3):272-280
ABSTRACTIntroduction: Hepatitis D infection causes severe form of viral hepatitis in humans and only affects those with hepatitis B either as a co-infection or superinfection. The aim of this study was to determine the prevalence of Hepatitis D and its effect on the immunologic and molecular profile of Hepatitis B among asymptomatic Chronic Hepatitis B patients in Abeokuta.Methodology: A cross-sectional study of 99 chronic HBV patient who met the inclusion criteria. All the patients were tested for HBsAg, anti HCV, HDV antigen, anti HDV, HBsAg quantification, and HBV DNA quantification. Associations were tested for and P value less than 0.05 was considered significant.Results: The participants included 53 (58%) male and 38 (42%) females with ages ranging from 18 to 69 (means 39 ± 11) years. Ten (11%) participants were positive for HDV-Ag while 1 (1.1%) was positive for anti-HDV. Five (5.5%) were positive for HIV 1 &2 while 1 (1.1%) was positive for anti HCV. HBV DNA quantification ranged from 15 to 17,000,000 IU/ml while HBsAg quantification ranged from 0.25 to45,520 IU/ml. There was no statistically significant relationship between HDV-Ag and age (p = .51), sex (p = .73), HBV DNA (p = .8) and HBsAg quantification (p = 1).Conclusion: The prevalence of HDV-Ag among asymptomatic treatment naïve chronic hepatitis B patients in Abeokuta was 11% and there was no significant difference in the levels of HBV DNA and HBsAg among those with or without hepatitis D. 相似文献
10.
Hilary S Whitworth Amarjit Badhan Aime A Boakye Yemisi Takwoingi Melanie Rees-Roberts Christopher Partlett Heather Lambie John Innes Graham Cooke Marc Lipman Christopher Conlon Derek Macallan Felix Chua Frank A Post Martin Wiselka Gerrit Woltmann Jonathan J Deeks Onn Min Kon Sarah Menzies 《The Lancet infectious diseases》2019,19(2):193-202