排序方式: 共有6条查询结果,搜索用时 15 毫秒
1
1.
Woraphat Ratta-apha Akitoyo Hishimoto Kentaro Mouri Kyoichi Shiroiwa Toru Sasada Masakuni Yoshida Irwan Supriyanto Yasuhiro Ueno Migiwa Asano Osamu Shirakawa Hideru Togashi Yoshimi Takai Ichiro Sora 《Neuroscience research》2013
The Disrupted-in-Schizophrenia 1 (DISC1) gene plays a role in the regulation of neural development. Previous evidence from genetic association and biological studies implicates the DISC1 gene as having a role in the pathophysiology of schizophrenia. In the present study, we explored the association between DISC1 missense mutation rs821616 (Ser704Cys) single nucleotide polymorphism (SNP) and four other SNPs (rs1772702, rs1754603, rs821621, rs821624) in the related haplotype block and schizophrenia in the Japanese population. We could not find a significant association of selected SNPs with schizophrenia after correction for multiple testing. We performed a meta-analysis of the Ser704Cys variant in schizophrenia using data from the present study and five previous Japanese population studies, and found no association with schizophrenia. We also examined DISC1 immunoreactivity in postmortem prefrontal cortex specimens of schizophrenia patients compared to control samples. The immunoreactivity revealed a significant decrease of DISC1 protein expression in the schizophrenia samples after ruling out potential confounding factors. However, the Ser704Cys variant did not show effects on DISC1 immunoreactivity. These results provide evidence that this functional genetic variation of DISC1 do not underlie the pathophysiology of schizophrenia in the Japanese population. 相似文献
2.
Woraphat Ratta-apha Akitoyo Hishimoto Masakuni Yoshida Yasuhiro Ueno Migiwa Asano Osamu Shirakawa Ichiro Sora 《Psychiatry research》2013
We explored the association between the brain-derived neurotrophic factor gene with suicide using 307 Japanese completed suicides, 380 healthy controls, and data from previously published samples. The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide. 相似文献
3.
Pornnoppadol Chanvit Ratta-apha Woraphat Chanpen Sirinda Wattananond Supattra Dumrongrungruang Nootchanet Thongchoi Kanthip Panchasilawut Suphaphorn Wongyuen Benyapa Chotivichit Apakorn Laothavorn Juntira Vasupanrajit Asara 《International journal of mental health and addiction》2020,18(4):932-948
International Journal of Mental Health and Addiction - The present study is a quasi-experimental, prospective study of interventions for internet gaming disorder (IGD). One hundred four parents and... 相似文献
4.
5.
Woraphat Ratta-apha Akitoyo Hishimoto Kentaro Mouri Kyoichi Shiroiwa Toru Sasada Masakuni Yoshida Satoshi Okazaki Irwan Supriyanto Migiwa Asano Yasuhiro Ueno Osamu Shirakawa Ichiro Sora 《Psychiatry research》2014
The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide. 相似文献
6.
1