全文获取类型
收费全文 | 1183篇 |
免费 | 114篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 67篇 |
妇产科学 | 31篇 |
基础医学 | 140篇 |
口腔科学 | 59篇 |
临床医学 | 99篇 |
内科学 | 268篇 |
皮肤病学 | 11篇 |
神经病学 | 58篇 |
特种医学 | 88篇 |
外科学 | 168篇 |
综合类 | 93篇 |
预防医学 | 76篇 |
眼科学 | 9篇 |
药学 | 105篇 |
中国医学 | 1篇 |
肿瘤学 | 33篇 |
出版年
2023年 | 6篇 |
2022年 | 14篇 |
2021年 | 16篇 |
2020年 | 12篇 |
2019年 | 13篇 |
2018年 | 16篇 |
2017年 | 14篇 |
2016年 | 21篇 |
2015年 | 30篇 |
2014年 | 18篇 |
2013年 | 35篇 |
2012年 | 42篇 |
2011年 | 42篇 |
2010年 | 36篇 |
2009年 | 48篇 |
2008年 | 36篇 |
2007年 | 54篇 |
2006年 | 71篇 |
2005年 | 39篇 |
2004年 | 22篇 |
2003年 | 35篇 |
2002年 | 31篇 |
2001年 | 32篇 |
2000年 | 19篇 |
1999年 | 51篇 |
1998年 | 61篇 |
1997年 | 39篇 |
1996年 | 44篇 |
1995年 | 21篇 |
1994年 | 30篇 |
1993年 | 37篇 |
1992年 | 28篇 |
1991年 | 25篇 |
1990年 | 11篇 |
1989年 | 28篇 |
1988年 | 36篇 |
1987年 | 23篇 |
1986年 | 24篇 |
1985年 | 26篇 |
1984年 | 13篇 |
1983年 | 11篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1979年 | 4篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1975年 | 6篇 |
1972年 | 5篇 |
1968年 | 4篇 |
排序方式: 共有1307条查询结果,搜索用时 15 毫秒
1.
2.
3.
J Wilton M D Noonan 《NAACOG's clinical issues in perinatal and women's health nursing》1991,2(4):527-532
As women 40-60 years of age become the fastest growing segment of the population, it is time for women's health care providers to identify the health care needs of these women and provide the appropriate services. In 1985, Northwestern Memorial Hospital developed the Menopause Center to address these concerns. The objectives of the Menopause Center are to inform women of the natural bodily changes menopause creates, dispel common myths about the menopause, identify risk factors for osteoporosis and heart disease, provide information regarding hormone replacement therapy, and provide a forum for women experiencing the menopause to share information. 相似文献
4.
5.
6.
7.
8.
Effects of anaerobiosis and aerobiosis on interactions of human polymorphonuclear leukocytes with the dental plaque bacteria Streptococcus mutans, Capnocytophaga ochracea, and Bacteroides gingivalis. 总被引:1,自引:2,他引:1
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Human polymorphonuclear leukocytes (PMN) were able to generate and release superoxide anions upon stimulation of Streptococcus mutans, Bacteroides gingivalis, and Capnocytophaga ochracea when incubated aerobically but not when incubated anaerobically. Lysozyme release and phagocytosis by PMN were independent of oxygen, and no difference between PMN incubated aerobically or anaerobically was observed (PMN stimulated by B. gingivalis released 7.6% total lysozyme when aerobic and 6.9% when anaerobic). There were variations in lysozyme release and phagocytosis for the three organisms, particularly for phagocytosis. B. gingivalis and C. ochracea yielded lower phagocytosis values than those for S. mutans, e.g., at 1 h 67% of the initial inoculum of S. mutans was phagocytosed (versus only 40% for B. gingivalis). Transmission electron microscopy showed that both S. mutans and B. gingivalis were internalized into classical phagolysosomes. In contrast, C. ochracea showed two forms of internalization; C. ochracea either formed a classical phagolysosome or was tightly bound in the cytoplasm with no surrounding cell membrane. Intracellular killing of S. mutans and C. ochracea was unaffected by anaerobiosis, but killing of C. ochracea was much lower than that of S. mutans (1 x 10(7) to 2 x 10(7) bacteria killed compared with 5.1 x 10(7) bacteria killed at 6 h). In contrast, a greater number of B. gingivalis was killed in the presence of oxygen (5.3 x 10(7) bacteria were killed when aerobically incubated and 1.9 x 10(7) bacteria were killed when anaerobically incubated). These results suggest that the ability to survive anaerobically may enable some bacteria to evade PMN killing; however, abnormal phagocytosis may represent a more efficient way to evade both oxygen-dependent and -independent killing mechanisms, leading to enhanced virulence of the organism. 相似文献
9.
A DNA amplification assay using the polymerase chain reaction technique designed for the rapid identification of Mycobacterium bovis organisms was used to test 211 human mycobacterial isolates and 177 clinical specimens previously submitted for routine mycobacterial culture. The procedures described could be used by routine or specialist laboratories for identification of M. tuberculosis complex organisms in 4 h and/or as a rapid screening method for the direct detection of M. tuberculosis complex organisms in specimens. 相似文献