Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension: a case report.

A case is presented in which a woman diagnosed with a longstanding history of idiopathic intracranial hypertension reported improvement of frontal headaches, photophobia, transient blindness, enlarged blind spots, and tinnitus after smoking marijuana. All these symptoms and signs were associated with increased intracranial pressure (220-425 mm of water). Treatment with dronabinol at a dose of 10 mg twice a day, then reduced to 5 mg twice a day, relieved all of her symptoms. Previously noted papilledema and enlargement of blind spots also resolved, and this, in the absence of psychoactive effect or weight gain.     

Single unit responses in the cervical sympathetic trunk upon somatic nerve stimulation

Pflügers Archiv - European Journal of Physiology -     

Vasoconstrictor and pilomotor fibres in skin nerves to the cat's tail

Summary Postganglionic neurones to the tail's skin of the cat were investigated with regard to their spontaneous activity, response characteristics to somatic stimuli and asphyxia, the conduction velocity of their axons, and the conduction velocity of the preganglionic axons converging on them. The cats were anaesthetized with chloralose, immobilized, and arteficially ventilated. With this regimen the postganglionic neurones were divided into two types: 1. Type 1 neurones are spontaneously active and exhibit reflexes upon somatic stimulation. During asphyxia they are mostly first depressed and then excited for about 2–3 min. Their axons conduct with 0.57±0.13 m/s (mean ± SD). The preganglionic axons converging on them conduct with 5.4±1.6 m/s. 2. Type 2 neurones are not spontaneously active and exhibit with few exceptions no reflexes on somatic stimuli. During asphyxia they are activated after 3–4 min, concomitantly with piloerection, when the activity in type 1 neurones is already decreasing. Their axons conduct with 0.84±0.14 m/s, the preganglionic axons converging on them conduct with 9.9±2.9 m/s. 3. From these characteristics it is concluded that type 1 neurones have vasomotor function and most type 2 neurones pilomotor function.     

Salmonella Subtypes with Increased MICs for Azithromycin in Travelers Returned to the Netherlands

Antimicrobial susceptibility was analyzed for 354 typhoidal Salmonella isolates collected during 1999–2012 in the Netherlands. In 16.1% of all isolates and in 23.8% of all isolates that showed increased MICs for ciprofloxacin, the MIC for azithromycin was increased. This resistance may complicate empirical treatment of enteric fever.