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V. Wewer C. Strandberg A. Pærregaard P. A. Krasilnikoff 《European journal of pediatrics》1997,156(10):787-788
We report on our experience with routine abdominal ultrasonography in 120 children (aged 3–15 years) with recurrent abdominal
pain, in order to determine the diagnostic value of this investigation. Eight children (7%) revealed sonographic abnormalities:
gallbladder stone (n = 2), splenomegaly (n = 1) and urogenital abnormalities (n = 5). The recurrent abdominal pain could be explained by these findings in only two (may be three) cases.
Conclusion The diagnostic value of abdominal ultra‐sonography in unselected children with recurrent abdominal pain is low. However,
the direct visualization of the abdominal structures as being normal may be helpful to the parents and the child in their
understanding and acceptance of the benign nature of recurrent abdominal pain.
Received: 19 March 1996 / Accepted: 29 January 1997 相似文献
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Susanne Holck Ulla M. Wewer Reidar Albrechtsen 《Virchows Archiv : an international journal of pathology》1987,411(4):311-314
Summary Light bodies are large cytoplasmic granules originally described in the gonadotrophic cells of the rat pituitary gland. In order to determine whether similar bodies occur in the human anterior pituitary gland, 89 pituitary adenomas and periadenomatous tissue from 20 cases were examined by transmission electron microscopy. Double membrane bound bodies with filamentous internal structure identical to rodent light bodies were identified in 10 hormone-producing adenomas: 5 PRL, 1 PRL-GH, 2 GH, and 2 ACTH-producing tumours. No light bodies were found in the remaining 79 tumours nor in the pituitary cells in periadenomatous tissue from 20 cases. These results show that some human pituitary adenomas may contain light bodies identical to those seen in gonadotrophs of rat pituitary.Abbreviations PRL
prolactin
- GH
growth hormone
- ACTH
adenocorticotropic hormone
- FSH
follicle-stimulating hormone
- LH
luteinizing hormone 相似文献
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Stephan Sachs PhD Lili Niu PhD Philipp Geyer PhD Sigrid Jall PhD Maximilian Kleinert PhD Annette Feuchtinger PhD Kerstin Stemmer PhD Markus Brielmeier DVM Brian Finan PhD Richard D. DiMarchi PhD Matthias H. Tschöp MD Nicolai Wewer Albrechtsen PhD Matthias Mann PhD Timo D. Müller PhD Susanna M. Hofmann MD 《Diabetes, obesity & metabolism》2021,23(1):195-207
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Rune E. Kuhre PhD Carolyn F. Deacon DMSci Nicolai J. Wewer Albrechtsen PhD Jens J. Holst DMSci 《Diabetes, obesity & metabolism》2021,23(9):2009-2019
Sodium-glucose co-transporter-2 inhibitors (SGLT2is) lower blood glucose and are used for treatment of type 2 diabetes. However, SGLT2is have been associated with increases in endogenous glucose production (EGP) by mechanisms that have been proposed to result from SGLT2i-mediated increases in circulating glucagon concentrations, but the relative importance of this effect is debated, and mechanisms possibly coupling SGLT2is to increased plasma glucagon are unclear. A direct effect on alpha-cell activity has been proposed, but data on alpha-cell SGLT2 expression are inconsistent, and studies investigating the direct effects of SGLT2 inhibition on glucagon secretion are conflicting. By contrast, alpha-cell sodium-glucose co-transporter-1 (SGLT1) expression has been found more consistently and appears to be more prominent, pointing to an underappreciated role for this transporter. Nevertheless, the selectivity of most SGLT2is does not support interference with SGLT1 during therapy. Paracrine effects mediated by secretion of glucagonotropic/static molecules from beta and/or delta cells have also been suggested to be involved in SGLT2i-induced increase in plasma glucagon, but studies are few and arrive at different conclusions. It is also possible that the effect on glucagon is secondary to drug-induced increases in urinary glucose excretion and lowering of blood glucose, as shown in experiments with glucose clamping where SGLT2i-associated increases in plasma glucagon are prevented. However, regardless of the mechanisms involved, the current balance of evidence does not support that SGLT2 plays a crucial role for alpha-cell physiology or that SGLT2i-induced glucagon secretion is important for the associated increased EGP, particularly because the increase in EGP occurs before any rise in plasma glucagon. 相似文献
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Kim K. B. Clemmensen MD Martin B. Blond PhD Hanan Amadid PhD Lea Bruhn MSc Dorte Vistisen PhD Kristian Karstoft PhD Frederik Persson DMSc Mathias Ried-Larsen PhD Jens J. Holst DMSc Nicolai J. Wewer Albrechtsen PhD Signe S. Torekov PhD Jonas S. Quist PhD Marit E. Jørgensen PhD Kristine Færch PhD 《Diabetes, obesity & metabolism》2021,23(2):530-539
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Elias Badal Rashu Anders Ellekær Junker Karen Vagner Danielsen Emilie Dahl Ole Hamberg Line Borgwardt Vibeke Brix Christensen Nicolai J Wewer Albrechtsen Lise L Gluud 《World Journal of Clinical Cases》2020,8(9):1642-1650
BACKGROUND Cholesteryl ester storage disease(CESD)is a rare genetic disease.Its symptoms and severity are highly variable.CESD is a systemic disease that can lead to the accumulation of fat and inflammation in the liver,as well as gastrointestinal and cardiovascular disease.The majority of patients require liver transplantation due to decompensated cirrhosis.Enzyme replacement therapy has been approved based on a randomized trial.Our study aims to clinically and genetically evaluate two siblings with CESD who underwent liver transplantation,as well as their first-degree family members.CASE SUMMARY The siblings were compound heterozygous for the missense variant in LIPA exon 8,c.894G>A,(p.Gln298Gln)and a single base pair deletion,c.482del(p.Asn161Ilefs*19).Analyses of single nucleotide polymorphisms showed variants with an increased risk of fatty liver disease and fibrosis for both patients.Clinically,both patients show signs of recurrence of CESD in the liver after transplantation and additional gastrointestinal and cardiovascular signs of CESD.Three family members who were LIPA heterozygous had a lysosomal acid lipase activity below the reference value.One of these carriers,a seven-year-old boy,was found to have severe dyslipidemia and was subsequently treated with statins.CONCLUSION Our study underlines that CESD is a multi-organ disease,the progression of which may occur post-liver transplantation.Our findings underline the need for monitoring of complications and assessment of possible further treatment. 相似文献