氟喹诺酮类药物不良反应168例分析

0 引言 随着氟喹诺酮类药物在临床的广泛应用，有关其应用所致不良反应的报道也日趋增多，我们通过对1990／2003年我院氟喹诺酮类药物不良反应情况报告如下，供临床参考。     

Relation between temperature and processes of spontaneous quantum and non-quantum mediator release from motor nerve endings of the mouse

The spontaneous quantal and nonquantal acetylcholine release was investigated at the temperature range from 10 to 35 degrees C in white mouse semidiaphragm. The quantal release was evaluated by calculation of miniature end-plate potentials frequency, while the nonquantal one--from the H-effect value. The spontaneous quantal release increased exponentially with the temperature growth. The temperature dependence of the nonquantal release showed two relative maxima: at 20 degrees and 35 degrees C. At 10 degrees C the nonquantal release was absent. The value of calculated effective energy of activation of the quantal release was 57.0 kJ/mol in the investigated temperature range. The effective energy of activation for the nonquantal release process in intervals 15-20 degrees C and 25-35 degrees C was 45.5 and 38.2 kJ/mol, relatively. It is suggested that the nonquantal release is rather due to active transport processes than to simple diffusion of acetylcholine molecules.     

Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin

The biophysical properties of non-eczematous skin at three locations in atopics and non-atopics were characterized using non-invasive physical methods. Skin friction was measured with a newly developed sliding friction instrument, the degree of hydration with a capacitance meter (Corneometer CM 820), and the transepidermal water loss (TEWL) was determined using an Evaporimeter EP1. The areas examined (dorsum of the hand, volar forearm and lower back) showed lower values of friction and capacitance in the atopic patients than did corresponding sites in the normal controls. In most areas a significant correlation between friction and capacitance was found. The TEWL was increased in atopic skin, but TEWL seems to correlate neither to friction nor to capacitance.     

Ärztliche Fehleroffenbarung – Strafrechtliche Strategien für postinvasive Arzt-Patientengespräche

Ohne Zusammenfassung     

Disordered associative long-term potentiation in the hippocampus after the tetanization of the reinforcing input

Field potentials (FPs) were recorded from stratum radiatum of CA1 region of mouse hippocampal slices after weak orthodromic stimulation (C2). Associative long-term potentiation (ALTP), induced by simultaneous tetanization of C2 with strong tetanization of another group of fibres (C1) was investigated. Effects of the additional tetanization of C1 delivered 50-300 ms before and 50-300 ms after conjoint tetanization of two inputs were compared. In experiments with intervals 50-200 ms preliminary tetanizations of C1 suppressed ALTP (the FPs amplitude increase was 10.4 +/- 5.2%) in comparison with procedure in which an additional tetanization of C1 follows conjoint tetanization (the FPs increase was 32.4 +/- 5.3%). There was no significant difference between two procedures in experiments with 300 ms intervals. Three mechanisms have been considered to explain the influence of the preliminary strong tetanus on ALTP: inactivation of "fast" calcium channels, afterburst hyperpolarization and synaptic inhibition. It is suggested that mechanisms of this suppression are similar to mechanisms underlying relative inefficacy of the "backward" association procedure in behavioral conditioning.