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Asimina Dominari Donald Hathaway III Abdulhusein Kapasi Trissa Paul Sarabjot Singh Makkar Valeria Castaneda Sirisha Gara Bishnu Mohan Singh Kuchalambal Agadi Maliha Butt Varadha Retnakumar Spandana Chittajallu Rahima Taugir Muhammad Khawar Sana Manish KC Sarah Razzack Niala Moallem Alina Alvarez Michael Talalaev 《World Journal of Virology》2021,10(2):34-52
N-acetylcysteine (NAC) is an abundantly available antioxidant with a wide range of antidotal properties currently best studied for its use in treating acetaminophen overdose. It has a robustly established safety profile with easily tolerated side effects and presents the Food and Drug Administration's approval for use in treating acetaminophen overdose patients. It has been proven efficacious in off-label uses, such as in respiratory diseases, heart disease, cancer, human immunodeficiency virus infection, and seasonal influenza. Clinical trials have recently shown that NAC's capacity to replenish glutathione stores may significantly improve coronavirus disease 2019 (COVID-19) outcomes, especially in high risk individuals. Interestingly, individuals with glucose 6-phosphate dehydrogenase deficiency have been shown to experience even greater benefit. The same study has concluded that NAC's ability to mitigate the impact of the cytokine storm and prevent elevation of liver enzymes, C-reactive protein, and ferritin is associated with higher success rates weaning from the ventilator and return to normal function in COVID-19 patients. Considering the background knowledge of biochemistry, current uses of NAC in clinical practice, and newly acquired evidence on its potential efficacy against COVID-19, it is worthwhile to investigate further whether this agent can be used as a treatment or adjuvant for COVID-19. 相似文献
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Syndromic forms of cortical maldevelopment continue to be a curiosity. Hypomelanosis of Ito (HI) is the presence of whirled
hypochromic skin lesions often associated with nondermatological manifestations. The polymorphism of brain abnormalities associated
with HI is well known. We report three cases of Hypomelanosis of Ito, occuring in infants, and associated with cerebral malformation. 相似文献
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Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐ butanone‐induced lung carcinogenesis potentially through down‐regulation of p38 and Akt phosphorylation in A/J mice
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