全文获取类型
收费全文 | 271篇 |
免费 | 22篇 |
专业分类
儿科学 | 12篇 |
妇产科学 | 4篇 |
基础医学 | 41篇 |
口腔科学 | 7篇 |
临床医学 | 25篇 |
内科学 | 36篇 |
皮肤病学 | 8篇 |
神经病学 | 16篇 |
特种医学 | 11篇 |
外科学 | 56篇 |
综合类 | 5篇 |
预防医学 | 13篇 |
眼科学 | 7篇 |
药学 | 28篇 |
中国医学 | 2篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 1篇 |
2022年 | 11篇 |
2021年 | 12篇 |
2020年 | 6篇 |
2019年 | 4篇 |
2018年 | 14篇 |
2017年 | 11篇 |
2016年 | 13篇 |
2015年 | 13篇 |
2014年 | 24篇 |
2013年 | 10篇 |
2012年 | 39篇 |
2011年 | 28篇 |
2010年 | 24篇 |
2009年 | 12篇 |
2008年 | 17篇 |
2007年 | 15篇 |
2006年 | 7篇 |
2005年 | 9篇 |
2004年 | 13篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
排序方式: 共有293条查询结果,搜索用时 31 毫秒
1.
Identification of PTPN22, ST6GAL1 and JAZF1 as psoriasis risk genes demonstrates shared pathogenesis between psoriasis and diabetes 下载免费PDF全文
Honglei Wang Zhenzhen Wang Parimi Leela Rani Xi'an Fu Wenjun Yu Fangfang Bao Gongqi Yu Jianke Li Lulu Li Lele Sun Zhenhua Yue Qing Zhao Qing Pan Jing Cao Chuan Wang Xiaojun Chi Yaru Wang Qing Yang Zihao Mi Hong Liu Furen Zhang 《Experimental dermatology》2017,26(11):1112-1117
The biological connections between psoriasis and diabetes have been suggested by epidemiological, immunological and genetic studies. To identify additional shared susceptibility loci and investigate shared pathogenesis between these two diseases, we genotyped 89 reported diabetes susceptibility loci in 4456 psoriasis cases and 6027 controls of Chinese population using the MassARRAY system from Sequenom. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15×10?5, OR=5.07), rs16861329 on 3q27.3 (P=2.02×10?4, OR=0.87) and rs849135 on 7p15.1 (P=6.59×10?9, OR=1.78), which suggested PTPN22, ST6GAL1 and JAZF1 as novel susceptibility genes for psoriasis in Chinese population. Our findings implicated the involvement of T‐cell receptor signalling pathway in the pathogenesis of psoriasis and further confirmed the shared genetic susceptibility between psoriasis and diabetes. 相似文献
2.
3.
Arun A. Mavanur Vamsi Parimi Mark O’Malley Marina Nikiforova David L. Bartlett Jon M. Davison 《International journal of experimental pathology》2010,91(4):357-367
We describe the clinical, pathologic and molecular characteristics of a xenograft model of metastatic mucinous appendiceal adenocarcinoma. Tumours from patients with mucinous appendiceal neoplasms were implanted in nude mice and observed for evidence of intraperitoneal tumour growth. Morphologic and immunohistochemical features, temporal growth characteristics relative to controls, and loss of heterozygosity (LOH) at multiple chromosomal alleles were assessed in a successfully engrafted tumour. Two of seventeen implanted tumours successfully engrafted and only one mucinous adenocarcinoma propagated throughout the course of the study. The successful xenograft is morphologically similar to the original tumour, produces abundant extracellular mucin and exhibits non‐invasive growth on peritoneal surfaces. The temporal growth characteristics of the xenograft tumour relative to controls reveal that tumour burden can be followed indirectly by measuring the weight or abdominal girth of engrafted animals. The cytokeratin, mucin core protein, CDX2, Ki‐67 and p53 expression patterns are identical in the xenograft and resected tumour and are consistent with the expected pattern of protein expression for mucinous adenocarcinoma of the appendix. LOH was found in 1 of 10 informative chromosomal loci (chromosome 10p23) in xenograft tumour cells. Although we were unable to engraft a low‐grade appendiceal mucinous neoplasm, the engrafted adenocarcinoma will be useful for future evaluation of novel therapeutic strategies directed at mucinous appendiceal adenocarcinoma and evaluation of strategies for treating widespread, bulky, mucinous peritoneal surface neoplasms. Xenograft tumour enrichment can facilitate molecular studies of appendiceal epithelial neoplasia. 相似文献
4.
Speech is essential to human activity, therefore phonetics must be considered with mechanics and esthetics as the cardinal factors contributing to the success of the dental prosthesis. The aim of this following procedure is to produce dentures that are mechanically functional, esthetically pleasing and permit normal speech. 相似文献
5.
6.
7.
Lavu Vamsi Gutknecht Norbert Vasudevan Amrutha S.K Balaji Hilgers Ralf-Dieter Franzen Rene 《Lasers in medical science》2022,37(3):1625-1634
Lasers in Medical Science - The objective of this prospective randomized controlled single-center clinical trial was to prove the efficacy of adjunctive photobiomodulation in improving selected... 相似文献
8.
In the current petroleum refining scenario, many refineries end up with surplus naphtha which is either absorbed into the gasoline pool or exported at unattractive prices. Therefore, several options for naphtha valorisation are currently being explored. The usage of Liquified Petroleum Gas (LPG) as a fuel in heating appliances, cooking equipment and automobiles is rapidly increasing. The high specific calorific value, high octane number, clean and efficient combustion of LPG distinguish it as an extremely promising fuel of the future. In the current work, tungstophosphoric acid (TPA) supported on four different mesoporous silica supports were investigated as mesoporous superacids for hydroconversion of refinery naphtha using n-heptane as a model feedstock. The varied levels of interactions of prepared mesoporous silica with tungstophosphoric acid catalysts were observed to have a prominent effect on the strength of the acid sites generated on silica surfaces and as a result affected heptane hydroconversion activity and selectivity of isomerized and cracked products. Interestingly, activity could be tuned towards selective cracking or isomerization-cracking by selection of a suitable topology of mesoporous silica. Hexagonal Mesoporous Silica (HMS) and plugged SBA-15 supported TPA catalysts demonstrated high n-heptane conversion activity and isomerization selectivity whereas KIT-6 and SBA-15 supported TPA catalysts demonstrated high cracking selectivity to LPG.TPA silanol interactions in mesoporous TPA silica composites govern the strength of acid sites, activity and selectivity. 相似文献
9.
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics 总被引:2,自引:0,他引:2 下载免费PDF全文
10.
Extracting and summarizing white matter hyperintensities using supervised segmentation methods in Alzheimer's disease risk and aging studies 下载免费PDF全文
Vamsi Ithapu Vikas Singh Christopher Lindner Benjamin P. Austin Chris Hinrichs Cynthia M. Carlsson Barbara B. Bendlin Sterling C. Johnson 《Human brain mapping》2014,35(8):4219-4235
Precise detection and quantification of white matter hyperintensities (WMH) observed in T2‐weighted Fluid Attenuated Inversion Recovery (FLAIR) Magnetic Resonance Images (MRI) is of substantial interest in aging, and age‐related neurological disorders such as Alzheimer's disease (AD). This is mainly because WMH may reflect co‐morbid neural injury or cerebral vascular disease burden. WMH in the older population may be small, diffuse, and irregular in shape, and sufficiently heterogeneous within and across subjects. Here, we pose hyperintensity detection as a supervised inference problem and adapt two learning models, specifically, Support Vector Machines and Random Forests, for this task. Using texture features engineered by texton filter banks, we provide a suite of effective segmentation methods for this problem. Through extensive evaluations on healthy middle‐aged and older adults who vary in AD risk, we show that our methods are reliable and robust in segmenting hyperintense regions. A measure of hyperintensity accumulation, referred to as normalized effective WMH volume, is shown to be associated with dementia in older adults and parental family history in cognitively normal subjects. We provide an open source library for hyperintensity detection and accumulation (interfaced with existing neuroimaging tools), that can be adapted for segmentation problems in other neuroimaging studies. Hum Brain Mapp 35:4219–4235, 2014. © 2014 Wiley Periodicals, Inc . 相似文献